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    Cdk5 Cyclin-dependent kinase 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36727, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdk5provided by FlyBase
    Official Full Name
    Cyclin-dependent kinase 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0013762
    Locus tag
    Dmel_CG8203
    See related
    AllianceGenome:FB:FBgn0013762
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdk5; CDK5; CG8203; DmCdk5; Dmel\CG8203
    Summary
    Enables cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including determination of adult lifespan; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and melanotic encapsulation of foreign target. Part of protein kinase 5 complex. Is expressed in adult head; organism; presumptive embryonic/larval central nervous system; and presumptive embryonic/larval nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Cdk5 in Genome Data Viewer
    Location:
    52A13-52A13; 2-74 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15569528..15571417, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11457033..11458922, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Flotillin 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-278 stem loop

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in nucleus  
    part_of protein kinase 5 complex PubMed 

    General protein information

    Preferred Names
    Cyclin-dependent kinase 5
    Names
    CG8203-PA
    Cdk5-PA
    NP_477080.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15569528..15571417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057732.4 → NP_477080.1  Cyclin-dependent kinase 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477080.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48609, Q94878, Q9V7D8
      Related
      FBpp0086483
      Conserved Domains (1) summary
      cd07839
      Location:3 → 286
      STKc_CDK5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5
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