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CycJ Cyclin J [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38428, updated on 9-Dec-2024

Summary

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Official Symbol
CycJprovided by FlyBase
Official Full Name
Cyclin Jprovided by FlyBase
Primary source
FLYBASE:FBgn0010317
Locus tag
Dmel_CG10308
See related
AllianceGenome:FB:FBgn0010317
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cdi5; Cdi5; CDI5; CG10308; cycJ; cyclinJ; Dmel\CG10308
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in germarium-derived egg chamber formation and mitotic cell cycle, embryonic. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Is expressed in nurse cell; organism; pole plasm; primordial germ cell; and unfertilized egg. Orthologous to several human genes including CCNJL (cyclin J like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CycJ in Genome Data Viewer
Location:
63E1-63E1; 3-8 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3466428..3468098)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3466428..3468098)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene uncharacterized protein Neighboring gene armitage Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A role for cyclin J in the rapid nuclear division cycles of early Drosophila embryogenesis. Kolonin MG, et al. Dev Biol, 2000 Nov 15. PMID 11071782
  2. A role for Drosophila Cyclin J in oogenesis revealed by genetic interactions with the piRNA pathway. Atikukke G, et al. Mech Dev, 2014 Aug. PMID 24946235, Free PMC Article
  3. Drosophila Cyclin J is a mitotically stable Cdk1 partner without essential functions. Althoff F, et al. Dev Biol, 2009 Sep 15. PMID 19591820
  4. Interaction mating reveals binary and ternary connections between Drosophila cell cycle regulators. Finley RL Jr, et al. Proc Natl Acad Sci U S A, 1994 Dec 20. PMID 7809159, Free PMC Article
  5. Isolation of Drosophila cyclin D, a protein expressed in the morphogenetic furrow before entry into S phase. Finley RL Jr, et al. Proc Natl Acad Sci U S A, 1996 Apr 2. PMID 8610160, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in germarium-derived egg chamber formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin J
Names
CG10308-PA
CG10308-PB
CycJ-PA
CycJ-PB
Cyclin-dependent kinase interactor 5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3466428..3468098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079179.3 → NP_523903.1  cyclin J, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523903.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24159, Q9VZP3
    Related
    FBpp0072987
    Conserved Domains (2) summary
    pfam00134
    Location:42 → 164
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:225 → 286
    Cyclin_C; Cyclin, C-terminal domain

  2. NM_206267.2 → NP_995989.1  cyclin J, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995989.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95U62
    Conserved Domains (1) summary
    pfam00134
    Location:42 → 164
    Cyclin_N; Cyclin, N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24159 Q24159
Q95U62 Q95U62
Q9VZP3 Q9VZP3

Gene LinkOut

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