Cep152 centrosomal protein 152 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cep152provided by MGI
Official Full Name: centrosomal protein 152provided by MGI
Primary source: MGI:MGI:2139083
See related: Ensembl:ENSMUSG00000068394 AllianceGenome:MGI:2139083
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0912
Summary: Predicted to enable protein kinase binding activity. Involved in centriole replication and de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Located in centrosome and deuterosome. Is expressed in several structures, including brain; lung; pharynx epithelium; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in Seckel syndrome 5 and primary autosomal recessive microcephaly 9. Orthologous to human CEP152 (centrosomal protein 152). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in CNS E11.5 (RPKM 4.4), liver E14 (RPKM 3.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 61.76 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (125391784..125467081, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (125549864..125625174, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

both mouse and human Cep63 and Cep152 cooperate to ensure efficient centriole duplication by promoting the accumulation of essential centriole duplication factors upstream of SAS-6 recruitment and procentriole formation.
Title: Cep63 and cep152 cooperate to ensure centriole duplication.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234515

AI851464 (e-PCR)
- UniSTS:165200

Cep152 (e-PCR), detects polymorphism
- UniSTS:532419

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in centriole replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in centriole replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centriole replication	ISO Inferred from Sequence Orthology more info
involved_in centrosome duplication	ISO Inferred from Sequence Orthology more info
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in deuterosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in pericentriolar material	ISO Inferred from Sequence Orthology more info
located_in pericentriolar material	ISS Inferred from Sequence or Structural Similarity more info
located_in procentriole	ISO Inferred from Sequence Orthology more info
part_of procentriole replication complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centrosomal protein of 152 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081091.1 → NP_001074560.1 centrosomal protein of 152 kDa

Status: VALIDATED

Source sequence(s)

AL928930, AL929166, BX321866

Consensus CDS

CCDS38229.1

UniProtKB/Swiss-Prot

A2AUM9, Q69ZV8, Q8R0X1

Related

ENSMUSP00000087208.3, ENSMUST00000089776.3

Conserved Domains (5) summary

COG1390
Location:1298 → 1422

NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]

pfam07106
Location:281 → 386

TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

cd16269
Location:794 → 803

GBP_C; coiled coil [structural motif]

cl20817
Location:610 → 803

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:977 → 1085

ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

125391784..125467081 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239870.3 → XP_011238172.1 centrosomal protein of 152 kDa isoform X2

Conserved Domains (2) summary

PTZ00121
Location:620 → 1272

PTZ00121; MAEBL; Provisional

TIGR02168
Location:238 → 812

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_036162757.1 → XP_036018650.1 centrosomal protein of 152 kDa isoform X6

Conserved Domains (2) summary

PTZ00121
Location:565 → 1074

PTZ00121; MAEBL; Provisional

COG0419
Location:276 → 803

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_036162756.1 → XP_036018649.1 centrosomal protein of 152 kDa isoform X3

Conserved Domains (2) summary

PTZ00121
Location:619 → 1271

PTZ00121; MAEBL; Provisional

TIGR02168
Location:235 → 811

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_006500474.5 → XP_006500537.1 centrosomal protein of 152 kDa isoform X1

Conserved Domains (2) summary

PTZ00121
Location:619 → 1271

PTZ00121; MAEBL; Provisional

TIGR02168
Location:237 → 811

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_017319354.3 → XP_017174843.1 centrosomal protein of 152 kDa isoform X5

Conserved Domains (2) summary

PTZ00121
Location:566 → 1075

PTZ00121; MAEBL; Provisional

TIGR02168
Location:238 → 812

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_011239871.3 → XP_011238173.1 centrosomal protein of 152 kDa isoform X4

Conserved Domains (2) summary

PTZ00121
Location:566 → 1075

PTZ00121; MAEBL; Provisional

TIGR02168
Location:238 → 812

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_036162760.1 → XP_036018653.1 centrosomal protein of 152 kDa isoform X9

Conserved Domains (2) summary

PTZ00121
Location:358 → 845

PTZ00121; MAEBL; Provisional

TIGR02168
Location:6 → 582

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_036162758.1 → XP_036018651.1 centrosomal protein of 152 kDa isoform X8

Conserved Domains (2) summary

PTZ00121
Location:390 → 1042

PTZ00121; MAEBL; Provisional

TIGR02168
Location:6 → 582

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_006500473.4 → XP_006500536.1 centrosomal protein of 152 kDa isoform X7

Conserved Domains (2) summary

PTZ00121
Location:390 → 1042

PTZ00121; MAEBL; Provisional

TIGR02168
Location:8 → 582

SMC_prok_B; chromosome segregation protein SMC, common bacterial type