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    CD46 CD46 molecule [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 714082, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CD46provided by VGNC
    Official Full Name
    CD46 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:70930
    See related
    Ensembl:ENSMMUG00000007129
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CD46 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (65254867..65292645)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (158786561..158824294, complement)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene complement C3b/C4b receptor 1 (Knops blood group) Neighboring gene fatty acid-binding protein 5 Neighboring gene protein ABHD4 pseudogene Neighboring gene microRNA mir-29b-2 Neighboring gene microRNA mir-29c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Artificial mutations and natural variations in the CD46 molecules from human and monkey cells define regions important for measles virus binding. Hsu EC, et al. J Virol, 1997 Aug. PMID 9223509, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in negative regulation of complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    membrane cofactor protein
    Names
    CD46 antigen, complement regulatory protein
    membrane cofactor protein CD46

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195746.1 → NP_001182675.1  membrane cofactor protein precursor

      Status: PROVISIONAL

      Source sequence(s)
      FS722731, U87922
      UniProtKB/TrEMBL
      A0A5K1V3R4
      Related
      ENSMMUP00000009335.3, ENSMMUT00000009946.4
      Conserved Domains (2) summary
      cd00033
      Location:228 → 283
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:162 → 223
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      65254867..65292645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015116875.1 → XP_014972361.1  membrane cofactor protein isoform X1

      UniProtKB/TrEMBL
      F7DTG0, F7DTG7, H9FUI7
      Related
      ENSMMUP00000009336.4, ENSMMUT00000009947.4
      Conserved Domains (2) summary
      cd00033
      Location:228 → 283
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:162 → 223
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    2. XM_015116902.1 → XP_014972388.1  membrane cofactor protein isoform X6

      UniProtKB/TrEMBL
      F7DTG7
      Conserved Domains (2) summary
      cd00033
      Location:228 → 283
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:162 → 223
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    3. XM_015116897.1 → XP_014972383.1  membrane cofactor protein isoform X4

      UniProtKB/TrEMBL
      A0A5K1V3R4, F7DTF4, H9FUI6, H9FUI8
      Related
      ENSMMUP00000009337.4, ENSMMUT00000009948.4
      Conserved Domains (2) summary
      cd00033
      Location:228 → 283
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:162 → 223
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    4. XM_015116884.1 → XP_014972370.1  membrane cofactor protein isoform X2

      UniProtKB/TrEMBL
      F7DTG7, I0FRS6
      Conserved Domains (2) summary
      cd00033
      Location:228 → 283
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:162 → 223
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    5. XM_015116915.1 → XP_014972401.1  membrane cofactor protein isoform X8

      UniProtKB/TrEMBL
      O19127
      Conserved Domains (2) summary
      cd00033
      Location:228 → 283
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:162 → 223
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    6. XM_015116900.2 → XP_014972386.1  membrane cofactor protein isoform X5

      UniProtKB/TrEMBL
      A0A5K1V3R4
      Conserved Domains (2) summary
      cd00033
      Location:228 → 283
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:162 → 223
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    7. XM_015116909.1 → XP_014972395.1  membrane cofactor protein isoform X7

      UniProtKB/TrEMBL
      F7DTG7
      Conserved Domains (2) summary
      cd00033
      Location:185 → 240
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:119 → 180
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    8. XM_015116890.1 → XP_014972376.1  membrane cofactor protein isoform X3

      UniProtKB/TrEMBL
      F7DTG7
      Conserved Domains (2) summary
      cd00033
      Location:209 → 264
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:143 → 204
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    Nucleotide Protein
    Heading Accession and Version

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