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Conserved domains on  [gi|966921970|ref|XP_014972376|]
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membrane cofactor protein isoform X3 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
35-266 1.57e-41

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 146.34  E-value: 1.57e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921970  35 YRVGERVDYKCKKGYFYIPPLATHTICDRNhTWLPVSDegCYREMCPHIRDPLNGEaiLANGSYEFGAELHFICNEGYYL 114
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQ--LDIGGVDFGSSITYSCNSGYQL 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921970 115 IGKDILYCELKDTVA-IWSGKPPLCEKILCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESMIYCgN 193
Cdd:PHA02927 119 IGESKSYCELGSTGSmVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLC-S 191
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966921970 194 NSTWSHAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKCLK 266
Cdd:PHA02927 192 GGEWSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
35-266 1.57e-41

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 146.34  E-value: 1.57e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921970  35 YRVGERVDYKCKKGYFYIPPLATHTICDRNhTWLPVSDegCYREMCPHIRDPLNGEaiLANGSYEFGAELHFICNEGYYL 114
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQ--LDIGGVDFGSSITYSCNSGYQL 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921970 115 IGKDILYCELKDTVA-IWSGKPPLCEKILCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESMIYCgN 193
Cdd:PHA02927 119 IGESKSYCELGSTGSmVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLC-S 191
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966921970 194 NSTWSHAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKCLK 266
Cdd:PHA02927 192 GGEWSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
209-264 8.12e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 59.78  E-value: 8.12e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966921970 209 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 264
Cdd:cd00033    1 CPPPpVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
212-264 9.58e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 56.74  E-value: 9.58e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 966921970  212 PVVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 264
Cdd:pfam00084   5 PDIPNGK-VSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
209-264 1.52e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 1.52e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 966921970   209 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 264
Cdd:smart00032   1 CPPPpDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
35-266 1.57e-41

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 146.34  E-value: 1.57e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921970  35 YRVGERVDYKCKKGYFYIPPLATHTICDRNhTWLPVSDegCYREMCPHIRDPLNGEaiLANGSYEFGAELHFICNEGYYL 114
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQ--LDIGGVDFGSSITYSCNSGYQL 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921970 115 IGKDILYCELKDTVA-IWSGKPPLCEKILCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESMIYCgN 193
Cdd:PHA02927 119 IGESKSYCELGSTGSmVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLC-S 191
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966921970 194 NSTWSHAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKCLK 266
Cdd:PHA02927 192 GGEWSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
PHA02639 PHA02639
EEV host range protein; Provisional
98-266 3.14e-31

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 119.77  E-value: 3.14e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921970  98 YEFGAELHFICNEGYYLIGKDILYCELKDTVAIWSGKPPLCEKILCTPPPKIKNGKhTFSEVEVFEYLDAVTYSCDPAPG 177
Cdd:PHA02639  40 YEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAIWSNKAPFCMLKECNDPPSIINGK-IYNKREMYKVGDEIYYVCNEHKG 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921970 178 PDpFSLIGESMIYCGNNSTWSHAAPECKVVKCRFPVVENGkQISGF--GKKFYYKATVMFECDKGYYLNGSDKIVCESNS 255
Cdd:PHA02639 119 VQ-YSLVGNEKITCIQDKSWKPDPPICKMINCRFPALQNG-YINGIpsNKKFYYKTRVGFSCKSGFDLVGEKYSTCNINA 196
                        170
                 ....*....|.
gi 966921970 256 TWDPPVPKCLK 266
Cdd:PHA02639 197 TWFPSIPTCVR 207
PHA02817 PHA02817
EEV Host range protein; Provisional
138-270 9.94e-25

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 100.40  E-value: 9.94e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921970 138 CEKILCTPPPKIKNGkHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESMIYCGNNSTWSHAAPECKVVKCRFPVVENG 217
Cdd:PHA02817  19 CDLNKCCYPPSIKNG-YIYNKKTEYNIGSNVTFFCGNNTRGVRYTLVGEKNIICEKDGKWNKEFPVCKIIRCRFPALQNG 97
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966921970 218 kQISGF--GKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKCLKVSTS 270
Cdd:PHA02817  98 -FVNGIpdSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPICSRDNIT 151
PHA02831 PHA02831
EEV host range protein; Provisional
95-275 4.19e-21

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 91.59  E-value: 4.19e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921970  95 NGSYEFGAELHFICNEGYyliGKDILYCelkdTVAIWSGKPPLCEKILCTPPPKIKNGkHTFSEVEVFEYLDAVTYSCDp 174
Cdd:PHA02831  37 NKVYEENENLEYKCNNNF---DKVFVTC----NNGSWSTKNMCIGKRNCKDPVTILNG-YIKNKKDQYSFGDSVTYACK- 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921970 175 APGPDPFSLIGESMIYCgNNSTWSHAAPECKVVKCRFPVVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESN 254
Cdd:PHA02831 108 VNKLEKYSIVGNETVKC-INKQWVPKYPVCKLIRCKYPALQNGF-LNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDIN 185
                        170       180
                 ....*....|....*....|.
gi 966921970 255 STWDPPVPKCLKVSTSPTTKS 275
Cdd:PHA02831 186 SIWYPGIPKCVKDKVHNEIQP 206
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
209-264 8.12e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 59.78  E-value: 8.12e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966921970 209 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 264
Cdd:cd00033    1 CPPPpVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
80-139 3.45e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.86  E-value: 3.45e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921970  80 CPHIRDPLNGEAILANGSYEFGAELHFICNEGYYLIGKDILYCELKDTvaiWSGKPPLCE 139
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG---WSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
212-264 9.58e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 56.74  E-value: 9.58e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 966921970  212 PVVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 264
Cdd:pfam00084   5 PDIPNGK-VSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
209-264 1.52e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 1.52e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 966921970   209 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 264
Cdd:smart00032   1 CPPPpDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
80-138 5.40e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 54.45  E-value: 5.40e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 966921970    80 CPHIRDPLNGEAILANGSYEFGAELHFICNEGYYLIGKDILYCELKDTvaiWSGKPPLC 138
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT---WSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
143-204 5.45e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 54.45  E-value: 5.45e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966921970   143 CTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPapgpdPFSLIGESMIYCGNNSTWSHAAPEC 204
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDP-----GYTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
143-205 1.01e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 1.01e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966921970 143 CTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPapgpdPFSLIGESMIYCGNNSTWSHAAPECK 205
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNE-----GYTLVGSSTITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
143-204 4.59e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.03  E-value: 4.59e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966921970  143 CTPPPKIKNGKHTfSEVEVFEYLDAVTYSCDPapgpdPFSLIGESMIYCGNNSTWSHAAPEC 204
Cdd:pfam00084   1 CPPPPDIPNGKVS-ATKNEYNYGASVSYECDP-----GYRLVGSPTITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
80-138 9.04e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.57  E-value: 9.04e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 966921970   80 CPHIRDPLNGEAILANGSYEFGAELHFICNEGYYLIGKDILYCELKDTvaiWSGKPPLC 138
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGT---WSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
16-69 8.89e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 37.12  E-value: 8.89e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 966921970    16 CEAPPTFEAMELIGkPKPYYRVGERVDYKCKKGYFYIPPlaTHTICDRNHTWLP 69
Cdd:smart00032   1 CPPPPDIENGTVTS-SSGTYSYGDTVTYSCDPGYTLIGS--STITCLENGTWSP 51
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
16-69 1.23e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 36.67  E-value: 1.23e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966921970  16 CEAPPTFEAMELIGkPKPYYRVGERVDYKCKKGYFYIPPlaTHTICDRNHTWLP 69
Cdd:cd00033    1 CPPPPVPENGTVTG-SKGSYSYGSTVTYSCNEGYTLVGS--STITCTENGGWSP 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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