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Conserved domains on  [gi|966921978|ref|XP_014972395|]
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membrane cofactor protein isoform X7 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 11-242 9.51e-42

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 146.34  E-value: 9.51e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921978  11 YRVGERVDYKCKKGYFYIPPLATHTICDRNhTWLPVSDegCYREMCPHIRDPLNGEaiLANGSYEFGAELHFICNEGYYL 90
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQ--LDIGGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921978  91 IGKDILYCELKDTVA-IWSGKPPLCEKILCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESMIYCgN 169
Cdd:PHA02927 119 IGESKSYCELGSTGSmVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLC-S 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966921978 170 NSTWSHAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKCLK 242
Cdd:PHA02927 192 GGEWSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 11-242 9.51e-42

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 146.34  E-value: 9.51e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921978  11 YRVGERVDYKCKKGYFYIPPLATHTICDRNhTWLPVSDegCYREMCPHIRDPLNGEaiLANGSYEFGAELHFICNEGYYL 90
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQ--LDIGGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921978  91 IGKDILYCELKDTVA-IWSGKPPLCEKILCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESMIYCgN 169
Cdd:PHA02927 119 IGESKSYCELGSTGSmVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLC-S 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966921978 170 NSTWSHAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKCLK 242
Cdd:PHA02927 192 GGEWSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 185-240 8.33e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 59.78  E-value: 8.33e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966921978 185 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 240
Cdd:cd00033    1 CPPPpVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
188-240 9.85e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 56.74  E-value: 9.85e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 966921978  188 PVVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 240
Cdd:pfam00084   5 PDIPNGK-VSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 185-240 1.70e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 1.70e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 966921978   185 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 240
Cdd:smart00032   1 CPPPpDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 11-242 9.51e-42

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 146.34  E-value: 9.51e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921978  11 YRVGERVDYKCKKGYFYIPPLATHTICDRNhTWLPVSDegCYREMCPHIRDPLNGEaiLANGSYEFGAELHFICNEGYYL 90
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQ--LDIGGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921978  91 IGKDILYCELKDTVA-IWSGKPPLCEKILCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESMIYCgN 169
Cdd:PHA02927 119 IGESKSYCELGSTGSmVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLC-S 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966921978 170 NSTWSHAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKCLK 242
Cdd:PHA02927 192 GGEWSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
PHA02639 PHA02639
EEV host range protein; Provisional
 74-242 4.52e-31

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 119.00  E-value: 4.52e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921978  74 YEFGAELHFICNEGYYLIGKDILYCELKDTVAIWSGKPPLCEKILCTPPPKIKNGKhTFSEVEVFEYLDAVTYSCDPAPG 153
Cdd:PHA02639  40 YEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAIWSNKAPFCMLKECNDPPSIINGK-IYNKREMYKVGDEIYYVCNEHKG 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921978 154 PDpFSLIGESMIYCGNNSTWSHAAPECKVVKCRFPVVENGkQISGF--GKKFYYKATVMFECDKGYYLNGSDKIVCESNS 231
Cdd:PHA02639 119 VQ-YSLVGNEKITCIQDKSWKPDPPICKMINCRFPALQNG-YINGIpsNKKFYYKTRVGFSCKSGFDLVGEKYSTCNINA 196

                        170
                 ....*....|.
gi 966921978 232 TWDPPVPKCLK 242
Cdd:PHA02639 197 TWFPSIPTCVR 207
PHA02817 PHA02817
EEV Host range protein; Provisional
 114-246 1.80e-24

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 99.24  E-value: 1.80e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921978 114 CEKILCTPPPKIKNGkHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESMIYCGNNSTWSHAAPECKVVKCRFPVVENG 193
Cdd:PHA02817  19 CDLNKCCYPPSIKNG-YIYNKKTEYNIGSNVTFFCGNNTRGVRYTLVGEKNIICEKDGKWNKEFPVCKIIRCRFPALQNG 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966921978 194 kQISGF--GKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKCLKVSTS 246
Cdd:PHA02817  98 -FVNGIpdSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPICSRDNIT 151
PHA02831 PHA02831
EEV host range protein; Provisional
 71-251 9.28e-21

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 90.05  E-value: 9.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921978  71 NGSYEFGAELHFICNEGYyliGKDILYCelkdTVAIWSGKPPLCEKILCTPPPKIKNGkHTFSEVEVFEYLDAVTYSCDp 150
Cdd:PHA02831  37 NKVYEENENLEYKCNNNF---DKVFVTC----NNGSWSTKNMCIGKRNCKDPVTILNG-YIKNKKDQYSFGDSVTYACK- 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921978 151 APGPDPFSLIGESMIYCgNNSTWSHAAPECKVVKCRFPVVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESN 230
Cdd:PHA02831 108 VNKLEKYSIVGNETVKC-INKQWVPKYPVCKLIRCKYPALQNGF-LNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDIN 185

                        170       180
                 ....*....|....*....|.
gi 966921978 231 STWDPPVPKCLKVSTSPTTKS 251
Cdd:PHA02831 186 SIWYPGIPKCVKDKVHNEIQP 206
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 185-240 8.33e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 59.78  E-value: 8.33e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966921978 185 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 240
Cdd:cd00033    1 CPPPpVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 56-115 3.67e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.86  E-value: 3.67e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921978  56 CPHIRDPLNGEAILANGSYEFGAELHFICNEGYYLIGKDILYCELKDTvaiWSGKPPLCE 115
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG---WSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
188-240 9.85e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 56.74  E-value: 9.85e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 966921978  188 PVVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 240
Cdd:pfam00084   5 PDIPNGK-VSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 185-240 1.70e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 1.70e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 966921978   185 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 240
Cdd:smart00032   1 CPPPpDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 56-114 5.87e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 54.45  E-value: 5.87e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 966921978    56 CPHIRDPLNGEAILANGSYEFGAELHFICNEGYYLIGKDILYCELKDTvaiWSGKPPLC 114
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT---WSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 119-180 6.10e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 54.45  E-value: 6.10e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966921978   119 CTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPapgpdPFSLIGESMIYCGNNSTWSHAAPEC 180
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDP-----GYTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 119-181 1.02e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.62  E-value: 1.02e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966921978 119 CTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPapgpdPFSLIGESMIYCGNNSTWSHAAPECK 181
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNE-----GYTLVGSSTITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
119-180 4.74e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.03  E-value: 4.74e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966921978  119 CTPPPKIKNGKHTfSEVEVFEYLDAVTYSCDPapgpdPFSLIGESMIYCGNNSTWSHAAPEC 180
Cdd:pfam00084   1 CPPPPDIPNGKVS-ATKNEYNYGASVSYECDP-----GYRLVGSPTITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
56-114 9.20e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.57  E-value: 9.20e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 966921978   56 CPHIRDPLNGEAILANGSYEFGAELHFICNEGYYLIGKDILYCELKDTvaiWSGKPPLC 114
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGT---WSPPFPEC 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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