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Conserved domains on  [gi|307691209|ref|NP_001182675|]
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membrane cofactor protein precursor [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 54-285 1.00e-41

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 147.11  E-value: 1.00e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691209  54 YRVGERVDYKCKKGYFYIPPLATHTICDRNhTWLPVSDegCYREMCPHIRDPLNGEaiLANGSYEFGAELHFICNEGYYL 133
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQ--LDIGGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691209 134 IGKDILYCELKDTVA-IWSGKPPLCEKILCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESMIYCgN 212
Cdd:PHA02927 119 IGESKSYCELGSTGSmVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLC-S 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 307691209 213 NSTWSHAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKCLK 285
Cdd:PHA02927 192 GGEWSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 54-285 1.00e-41

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 147.11  E-value: 1.00e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691209  54 YRVGERVDYKCKKGYFYIPPLATHTICDRNhTWLPVSDegCYREMCPHIRDPLNGEaiLANGSYEFGAELHFICNEGYYL 133
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQ--LDIGGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691209 134 IGKDILYCELKDTVA-IWSGKPPLCEKILCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESMIYCgN 212
Cdd:PHA02927 119 IGESKSYCELGSTGSmVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLC-S 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 307691209 213 NSTWSHAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKCLK 285
Cdd:PHA02927 192 GGEWSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 228-283 9.63e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 59.78  E-value: 9.63e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 307691209 228 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 283
Cdd:cd00033    1 CPPPpVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
231-283 1.05e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 56.74  E-value: 1.05e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 307691209  231 PVVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 283
Cdd:pfam00084   5 PDIPNGK-VSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 228-283 1.83e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 1.83e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 307691209   228 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 283
Cdd:smart00032   1 CPPPpDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 54-285 1.00e-41

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 147.11  E-value: 1.00e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691209  54 YRVGERVDYKCKKGYFYIPPLATHTICDRNhTWLPVSDegCYREMCPHIRDPLNGEaiLANGSYEFGAELHFICNEGYYL 133
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQ--LDIGGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691209 134 IGKDILYCELKDTVA-IWSGKPPLCEKILCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESMIYCgN 212
Cdd:PHA02927 119 IGESKSYCELGSTGSmVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLC-S 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 307691209 213 NSTWSHAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKCLK 285
Cdd:PHA02927 192 GGEWSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
PHA02639 PHA02639
EEV host range protein; Provisional
 117-285 4.45e-31

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 119.77  E-value: 4.45e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691209 117 YEFGAELHFICNEGYYLIGKDILYCELKDTVAIWSGKPPLCEKILCTPPPKIKNGKhTFSEVEVFEYLDAVTYSCDPAPG 196
Cdd:PHA02639  40 YEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAIWSNKAPFCMLKECNDPPSIINGK-IYNKREMYKVGDEIYYVCNEHKG 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691209 197 PDpFSLIGESMIYCGNNSTWSHAAPECKVVKCRFPVVENGkQISGF--GKKFYYKATVMFECDKGYYLNGSDKIVCESNS 274
Cdd:PHA02639 119 VQ-YSLVGNEKITCIQDKSWKPDPPICKMINCRFPALQNG-YINGIpsNKKFYYKTRVGFSCKSGFDLVGEKYSTCNINA 196

                        170
                 ....*....|.
gi 307691209 275 TWDPPVPKCLK 285
Cdd:PHA02639 197 TWFPSIPTCVR 207
PHA02817 PHA02817
EEV Host range protein; Provisional
 157-289 1.60e-24

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 100.02  E-value: 1.60e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691209 157 CEKILCTPPPKIKNGkHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESMIYCGNNSTWSHAAPECKVVKCRFPVVENG 236
Cdd:PHA02817  19 CDLNKCCYPPSIKNG-YIYNKKTEYNIGSNVTFFCGNNTRGVRYTLVGEKNIICEKDGKWNKEFPVCKIIRCRFPALQNG 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 307691209 237 kQISGF--GKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKCLKVSTS 289
Cdd:PHA02817  98 -FVNGIpdSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPICSRDNIT 151
PHA02831 PHA02831
EEV host range protein; Provisional
 114-294 7.20e-21

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 91.21  E-value: 7.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691209 114 NGSYEFGAELHFICNEGYyliGKDILYCelkdTVAIWSGKPPLCEKILCTPPPKIKNGkHTFSEVEVFEYLDAVTYSCDp 193
Cdd:PHA02831  37 NKVYEENENLEYKCNNNF---DKVFVTC----NNGSWSTKNMCIGKRNCKDPVTILNG-YIKNKKDQYSFGDSVTYACK- 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691209 194 APGPDPFSLIGESMIYCgNNSTWSHAAPECKVVKCRFPVVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESN 273
Cdd:PHA02831 108 VNKLEKYSIVGNETVKC-INKQWVPKYPVCKLIRCKYPALQNGF-LNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDIN 185

                        170       180
                 ....*....|....*....|.
gi 307691209 274 STWDPPVPKCLKVSTSPTTKS 294
Cdd:PHA02831 186 SIWYPGIPKCVKDKVHNEIQP 206
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 228-283 9.63e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 59.78  E-value: 9.63e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 307691209 228 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 283
Cdd:cd00033    1 CPPPpVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 99-158 4.16e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.86  E-value: 4.16e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691209  99 CPHIRDPLNGEAILANGSYEFGAELHFICNEGYYLIGKDILYCELKDTvaiWSGKPPLCE 158
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG---WSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
231-283 1.05e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 56.74  E-value: 1.05e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 307691209  231 PVVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 283
Cdd:pfam00084   5 PDIPNGK-VSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 228-283 1.83e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 1.83e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 307691209   228 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKC 283
Cdd:smart00032   1 CPPPpDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 99-157 6.30e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 54.45  E-value: 6.30e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 307691209    99 CPHIRDPLNGEAILANGSYEFGAELHFICNEGYYLIGKDILYCELKDTvaiWSGKPPLC 157
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT---WSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 162-223 6.75e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 54.45  E-value: 6.75e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 307691209   162 CTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPapgpdPFSLIGESMIYCGNNSTWSHAAPEC 223
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDP-----GYTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 162-224 1.15e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.62  E-value: 1.15e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 307691209 162 CTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPapgpdPFSLIGESMIYCGNNSTWSHAAPECK 224
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNE-----GYTLVGSSTITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
162-223 5.08e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.03  E-value: 5.08e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 307691209  162 CTPPPKIKNGKHTfSEVEVFEYLDAVTYSCDPapgpdPFSLIGESMIYCGNNSTWSHAAPEC 223
Cdd:pfam00084   1 CPPPPDIPNGKVS-ATKNEYNYGASVSYECDP-----GYRLVGSPTITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
99-157 9.54e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.57  E-value: 9.54e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 307691209   99 CPHIRDPLNGEAILANGSYEFGAELHFICNEGYYLIGKDILYCELKDTvaiWSGKPPLC 157
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGT---WSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 35-88 1.01e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 37.12  E-value: 1.01e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 307691209    35 CEAPPTFEAMELIGkPKPYYRVGERVDYKCKKGYFYIPPlaTHTICDRNHTWLP 88
Cdd:smart00032   1 CPPPPDIENGTVTS-SSGTYSYGDTVTYSCDPGYTLIGS--STITCLENGTWSP 51
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 35-88 1.42e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 36.67  E-value: 1.42e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 307691209  35 CEAPPTFEAMELIGkPKPYYRVGERVDYKCKKGYFYIPPlaTHTICDRNHTWLP 88
Cdd:cd00033    1 CPPPPVPENGTVTG-SKGSYSYGSTVTYSCNEGYTLVGS--STITCTENGGWSP 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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