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TWD1 FKBP-type peptidyl-prolyl cis-trans isomerase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821718, updated on 18-Sep-2024

Summary

Official Symbol
TWD1
Official Full Name
FKBP-type peptidyl-prolyl cis-trans isomerase family protein
Primary source
TAIR:AT3G21640
Locus tag
AT3G21640
See related
Araport:AT3G21640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATFKBP42; FK506-BINDING PROTEIN 42; FKBP42; TWISTED DWARF 1; UCU2; ULTRACURVATA 2
Summary
encodes a 42 kDa FK506-binding protein (AtFKBP42) that possesses similarity to multidomain peptidyl-prolyl cis/trans isomerases (PPIases, EC 5.2.1.8), which are known to be components of mammalian steroid hormone receptor complexes. The protein appears to be localized to the plasma membrane by electron microscopy and binds to HSP90.1 and calmodulin in vitro. It also aggregates citrate synthase in vitro but does NOT show PPIase activity in vivo. Mutants are reduced in size and exhibit disoriented growth in all organs. Belongs to one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808) with potential to interact with Hsp90/Hsp70 as co-chaperones.
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Genomic context

See TWD1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
8
Sequence:
Chromosome: 3; NC_003074.8 (7618851..7621477, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ERD (early-responsive to dehydration stress) family protein Neighboring gene chitin elicitor receptor kinase 1 Neighboring gene Protein phosphatase 2A regulatory B subunit family protein Neighboring gene UBX domain-containing protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

NM_113059.3

Gene Ontology Provided by TAIR

Component Evidence Code Pubs
located_in plasma membrane PubMed 
located_in plasma membrane  

General protein information

Preferred Names
FKBP-type peptidyl-prolyl cis-trans isomerase family protein
NP_188801.2
  • TWISTED DWARF 1 (TWD1); CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide TPR2 (InterPro:IPR013105), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: rotamase FKBP 1 (TAIR:AT3G25230.2); Has 6043 Blast hits to 5631 proteins in 871 species: Archae - 12; Bacteria - 1331; Metazoa - 2461; Fungi - 414; Plants - 774; Viruses - 0; Other Eukaryotes - 1051 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    7618851..7621477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113059.3 → NP_188801.2  FKBP-type peptidyl-prolyl cis-trans isomerase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188801.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RWM0, Q9LDC0
    UniProtKB/TrEMBL
    A0A178V6X3, A0A5S9XEJ8
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