Similar studies for GEO DataSets (Select 200171119) - GEO DataSets

Select item 2001711191.

Haploinsufficiency of the Sin3/HDAC corepressor complex member SIN3B causes a syndromic intellectual disability/autism disorder

(Submitter supplied) Proteins involved in transcriptional regulation harbor a demonstrated enrichment of mutations in neurodevelopmental disorders. The Sin3 (Swi-independent 3)/histone deacetylase (HDAC) complex plays a central role in histone deacetylation and transcriptional repression. Among the two vertebrate paralogs encoding the Sin3 complex, SIN3A variants cause syndromic intellectual disability, but the clinical consequences of SIN3B haploinsufficiency in humans are uncharacterized. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
13 Samples

Download data: TXT

Series

Accession:: GSE171119

ID:: 200171119

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Select item 2000894592.

Genome wide binding of trr (ChIP-seq) and expression analysis (RNA-seq) of trr- and G9a mutant fly heads

(Submitter supplied) trr ChIP-seq, trr RNA-seq, G9a RNA-seq

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13304 GPL11203
13 Samples

Download data: TXT, WIG

Series

Accession:: GSE89459

ID:: 200089459

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Select item 2000984783.

YY1 haploinsufficiency causes an intellectual disability syndrome featuring transcriptional and chromatin dysfunction.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
56 Samples

Download data: TXT

Series

Accession:: GSE98478

ID:: 200098478

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Select item 2000984774.

YY1 haploinsufficiency causes an intellectual disability syndrome featuring transcriptional and chromatin dysfunction [ChIP-seq]

(Submitter supplied) Yin and yang 1 (YY1) is a well-known zinc-finger transcription factor with crucial roles in normal development and malignancy. YY1 acts both as a repressor and an activator of gene expression. We have identified 23 individuals with de novo mutations or deletions of YY1 and phenotypic features that define a syndrome of cognitive impairment, behavioral alterations, intrauterine growth retardation, feeding problems, and various congenital malformations. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
38 Samples

Download data: TXT

Series

Accession:: GSE98477

ID:: 200098477

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Select item 2000984765.

YY1 haploinsufficiency causes an intellectual disability syndrome featuring transcriptional and chromatin dysfunction [RNA-seq]

(Submitter supplied) Yin and yang 1 (YY1) is a well-known zinc-finger transcription factor with crucial roles in normal development and malignancy. YY1 acts both as a repressor and an activator of gene expression. We have identified 23 individuals with de novo mutations or deletions of YY1 and phenotypic features that define a syndrome of cognitive impairment, behavioral alterations, intrauterine growth retardation, feeding problems, and various congenital malformations. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
18 Samples

Download data: TXT

Series

Accession:: GSE98476

ID:: 200098476

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Select item 2000225546.

Genome-wide maps of Sin3A and Sin3B binding in C2C12 myoblasts and differentiated myotubes

(Submitter supplied) Sin3A and Sin3B bind to distinct and overlapping target sites. Sin3 proteins bind to distinct sites in cycling myoblasts whereas there is a converge of Sin3A and Sin3B proteins to sites in differentiated myotubes. We identified a subset of Sin3 target genes involved in muscle differentiation and physiology and showed that conditional ablation of Sin3 proteins in vivo in mouse results in sarcomere defects

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9185
14 Samples

Download data: BED

Series

Accession:: GSE22554

ID:: 200022554

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Select item 2000199887.

Six1 and Six4 function in myoblast differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
32 Samples

Download data: TXT

Series

Accession:: GSE19988

ID:: 200019988

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Select item 2000199688.

Gene Expression Profiling of C2C12 Myoblast Differentiation

(Submitter supplied) In this study, the C2C12 cell line, a model used to study myogenesis and regeneration, was allowed to differentiate from myoblast precursor cells to myotubes. Cells were harvested at 4 different timepoints to perform gene expression profiling. We identified genes that were up-regulated and down-regulated during the differentiation process.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
12 Samples

Download data: TXT

Series

Accession:: GSE19968

ID:: 200019968

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Select item 2000199679.

Gene Expression Profiling of siRNA Knock-Down of Six1, Six4 and Myogenin in C2C12

(Submitter supplied) Six1, Six4 and Myogenin are transcription factors that are known to be required for skeletal myogenesis. Currently, very little is known about the genes targeted by Six1 and Six4. Gene expression profiling when one or both transcription factors were knock-down by siRNA was performed to identify genes affected by their absence. We also hypothesized that Six1 and Six4 can work in cooperation with the myogenic regulatory factor (MRFs) family of transcription factors, such as Myogenin. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
20 Samples

Download data: TXT

Series

Accession:: GSE19967

ID:: 200019967

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Select item 20003765710.

AUTS2 project

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array; Genome variation profiling by genome tiling array

5 related Platforms
7 Samples

Download data: CEL, IDAT, TXT

Series

Accession:: GSE37657

ID:: 200037657

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Select item 20003765611.

Oligo array for CNV calling AUTS2 project [Bluegnome]

(Submitter supplied) Phenotypic and genotypic description of AUTS2 deletion patients found by Array analysis in an international cohort of intellectual disability (ID) and multiple congenital malformations (MCA).

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL15503
1 Sample

Download data: TXT

Series

Accession:: GSE37656

ID:: 200037656

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Select item 20003765412.

Oligo array for calling CNV's for AUTS2 project [NimbleGen]

(Submitter supplied) Phenotypic and genotypic description of AUTS2 deletion patients found by Array analysis in an international cohort of intellectual disability (ID) and multiple congenital malformations (MCA).

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL15502
1 Sample

Download data: TXT

Series

Accession:: GSE37654

ID:: 200037654

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Select item 20003714213.

SNP array for CNV calling AUTS2 project [Illumina]

(Submitter supplied) Phenotypic and genotypic description of AUTS2 deletion patients found by Array analysis in an international cohort of intellectual disability (ID) and multiple congenital malformations (MCA).

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platform:: GPL13314
1 Sample

Download data: IDAT, TXT

Series

Accession:: GSE37142

ID:: 200037142

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Select item 20003714114.

Oligo array for CNV calling AUTS2 project [Agilent]

(Submitter supplied) Phenotypic and genotypic description of AUTS2 deletion patients found by Array analysis in an international cohort of intellectual disability (ID) and multiple congenital malformations (MCA).

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL8693
2 Samples

Download data: TXT

Series

Accession:: GSE37141

ID:: 200037141

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Select item 20003695015.

SNP array for CNV calling AUTS2 project [Affymetrix]

(Submitter supplied) Phenotypic and genotypic description of AUTS2 deletion patients found by Array analysis in an international cohort of intellectual disability (ID) and multiple congenital malformations (MCA).

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platform:: GPL6801
2 Samples

Download data: CEL

Series

Accession:: GSE36950

ID:: 200036950

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Select item 20004683316.

De novo mutations in the genome organizer CTCF cause Intellectual Disability

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL13393
12 Samples

Download data: BED, XLS

Series

Accession:: GSE46833

ID:: 200046833

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Select item 20004683217.

De novo mutations in the genome organizer CTCF cause Intellectual Disability (ChIP-Seq)

(Submitter supplied) An increasing number of genes involved in chromatin structure and epigenetic regulation has been implicated in a variety of developmental disorders, often including intellectual disability. By trio exome sequencing and subsequent mutational screening we now identified two de novo frameshift mutations and one de novo missense mutation in the CTCF gene in individuals with intellectual disability, microcephaly and growth retardation. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
1 Sample

Download data: BED, XLS

Series

Accession:: GSE46832

ID:: 200046832

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Select item 20004683118.

De novo mutations in the genome organizer CTCF cause Intellectual Disability (RNA-Seq)

(Submitter supplied) An increasing number of genes involved in chromatin structure and epigenetic regulation has been implicated in a variety of developmental disorders, often including intellectual disability. By trio exome sequencing and subsequent mutational screening we now identified two de novo frameshift mutations and one de novo missense mutation in the CTCF gene in individuals with intellectual disability, microcephaly and growth retardation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13393
11 Samples

Download data: TXT

Series

Accession:: GSE46831

ID:: 200046831

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Select item 20024073419.

Analysis of gene expression in Idasanutlin-arrested SIN3A and SIN3B depleated cells

(Submitter supplied) mRNA expression analysis of arrested HCT116 cells (wild-type or SIN3B-/-) transfected with either non-targeting control siRNA or one of three SIN3A siRNAs and treated with Idasanulin to activate p53.