Similar studies for GEO DataSets (Select 200121136) - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Links from GEO DataSets

Items: 20

Select item 2001211361.

Genomic and Epigenomic EBF1 Alterations Modulate TERT Expression in Gastric Cancer [Capture-C]

(Submitter supplied) Multiple convergent pathways resulting in inhibition of the transcription factor EBF1 is a major cause of TERT upregulation.

Organism:: Homo sapiens

Type:: Other

Platform:: GPL21290
4 Samples

Download data: TXT

Series

Accession:: GSE121136

ID:: 200121136

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001624202.

Integrative Epigenomic and High-Throughput Functional Enhancer Profiling Reveals Determinants of Enhancer Heterogeneity in Gastric Cancer

(Submitter supplied) Enhancer variation has been proposed as a major cause of cancer heterogeneity – however, mechanisms driving patient-specific enhancer cartographies remain unclear. Here we applied microscale histone modification profiling to delineate the landscape of enhancers in primary gastric adenocarcinoma, analyzing 132 epigenomic profiles of primary tumors, normal tissues, and cell lines

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL11154
72 Samples

Download data: BW

Series

Accession:: GSE162420

ID:: 200162420

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001447143.

Genomic and Epigenomic EBF1 Alterations Modulate TERT Expression in Gastric Cancer [Chip-Seq + RNA-Seq]

(Submitter supplied) Multiple convergent pathways resulting in inhibition of the transcription factor EBF1 is a major cause of TERT upregulation.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20301 GPL11154
36 Samples

Download data: BW, TXT, XLS, XLSX

Series

Accession:: GSE144714

ID:: 200144714

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001215014.

Genomic and Epigenomic EBF1 Alterations Modulate TERT Expression in Gastric Cancer [RNA-seq]

(Submitter supplied) Multiple convergent pathways resulting in inhibition of the transcription factor EBF1 is a major cause of TERT upregulation.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
3 Samples

Download data: TXT

Series

Accession:: GSE121501

ID:: 200121501

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001214985.

Genomic and Epigenomic EBF1 Alterations Modulate TERT Expression in Gastric Cancer [histone]

(Submitter supplied) Multiple convergent pathways resulting in inhibition of the transcription factor EBF1 is a major cause of TERT upregulation.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
16 Samples

Download data: TXT

Series

Accession:: GSE121498

ID:: 200121498

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001214956.

Genomic and Epigenomic EBF1 Alterations Modulate TERT Expression in Gastric Cancer [ChIP-Seq - EBF1, EZH2]

(Submitter supplied) Multiple convergent pathways resulting in inhibition of the transcription factor EBF1 is a major cause of TERT upregulation.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21290 GPL11154
6 Samples

Download data: TXT

Series

Accession:: GSE121495

ID:: 200121495

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001211407.

Genomic and Epigenomic EBF1 Alterations Modulate TERT Expression in Gastric Cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing

Platforms:: GPL20301 GPL21290 GPL11154
75 Samples

Download data: BW, NARROWPEAK, TXT, XLS, XLSX

Series

Accession:: GSE121140

ID:: 200121140

PubMed Full text in PMC Similar studies

Select item 2001211398.

Genomic and Epigenomic EBF1 Alterations Modulate TERT Expression in Gastric Cancer [CapStarr-seq]

(Submitter supplied) Multiple convergent pathways resulting in inhibition of the transcription factor EBF1 is a major cause of TERT upregulation.

Organism:: Homo sapiens

Type:: Other

Platform:: GPL11154
2 Samples

Download data: NARROWPEAK

Series

Accession:: GSE121139

ID:: 200121139

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001208359.

Genomic and Epigenomic EBF1 Alterations Modulate TERT Expression in Gastric Cancer [ChIP-Seq - H3K27me3]

(Submitter supplied) Multiple convergent pathways resulting in inhibition of the transcription factor EBF1 is a major cause of TERT upregulation.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
8 Samples

Download data: TXT

Series

Accession:: GSE120835

ID:: 200120835

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011401810.

HNF4α Pathway Mapping Identifies Wild-type IDH1 as a Targetable Metabolic Node in Gastric Cancer

(Submitter supplied) Comprehensive downstream mapping of HNF4α revealed its role in regulating GC metabolism via regulation of IDH1

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL11154
23 Samples

Download data: TXT, XLS

Series

Accession:: GSE114018

ID:: 200114018

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20011905111.

Integrated Paired-end Enhancer Profiling and Whole-Genome Sequencing Reveals Recurrent CCNE1 and IGF2 Enhancer Hijacking in Primary Gastric Adenocarcinoma [Capture-C]

(Submitter supplied) H3K27ac paired-end NanoChIP-seq, whole-genome sequencing, RNA-seq and Hi-C were integrated to reveal tumor-associated structural variants contributing to gastric cancer.

Organism:: Homo sapiens

Type:: Other

Platform:: GPL21290
1 Sample

Download data: TXT

Series

Accession:: GSE119051

ID:: 200119051

PubMed Similar studies SRA Run Selector

Select item 20011849212.

Integrated Paired-end Enhancer Profiling and Whole-Genome Sequencing Reveals Recurrent CCNE1 and IGF2 Enhancer Hijacking in Primary Gastric Adenocarcinoma [CapStarr-seq]

(Submitter supplied) H3K27ac paired-end NanoChIP-seq, whole-genome sequecing, RNA-seq and Hi-C were integrated to reveal tumor-associated structural variants contributing to gastric cancer

Organism:: Homo sapiens

Type:: Other

Platform:: GPL11154
2 Samples

Download data: NARROWPEAK

Series

Accession:: GSE118492

ID:: 200118492

Select item 20011849113.

Integrated Paired-end Enhancer Profiling and Whole-Genome Sequencing Reveals Recurrent CCNE1 and IGF2 Enhancer Hijacking in Primary Gastric Adenocarcinoma [4C-Seq]

(Submitter supplied) H3K27ac paired-end NanoChIP-seq, whole-genome sequecing, RNA-seq and Hi-C were integrated to reveal tumor-associated structural variants contributing to gastric cancer

Organism:: Homo sapiens

Type:: Other

Platform:: GPL21290
4 Samples

Download data: WIG

Series

Accession:: GSE118491

ID:: 200118491

PubMed Similar studies SRA Run Selector

Select item 20011839214.

Integrated Paired-end Enhancer Profiling and Whole-Genome Sequencing Reveals Recurrent CCNE1 and IGF2 Enhancer Hijacking in Primary Gastric Adenocarcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Other; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21290 GPL11154
54 Samples

Download data: HIC, NARROWPEAK, TXT, WIG

Series

Accession:: GSE118392

ID:: 200118392

PubMed Similar studies

Select item 20011839115.

Integrated Paired-end Enhancer Profiling and Whole-Genome Sequencing Reveals Recurrent CCNE1 and IGF2 Enhancer Hijacking in Primary Gastric Adenocarcinoma (Hi-C)

(Submitter supplied) H3K27ac paired-end NanoChIP-seq, whole-genome sequecing, RNA-seq and Hi-C were integrated to reveal tumor-associated structural variants contributing to gastric cancer

Organism:: Homo sapiens

Type:: Other

Platform:: GPL21290
3 Samples

Download data: HIC

Series

Accession:: GSE118391

ID:: 200118391

PubMed Similar studies SRA Run Selector

Select item 20011795316.

Integrated Paired-end Enhancer Profiling and Whole-Genome Sequencing Reveals Recurrent CCNE1 and IGF2 Enhancer Hijacking in Primary Gastric Adenocarcinoma (ChIP-seq)

(Submitter supplied) H3K27ac paired-end NanoChIP-seq, whole-genome sequecing, RNA-seq and Hi-C were integrated to reveal tumor-associated structural variants contributing to gastric cancer

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21290 GPL11154
44 Samples

Download data: NARROWPEAK

Series

Accession:: GSE117953

ID:: 200117953

PubMed Similar studies SRA Run Selector

Select item 20018652117.

Regulatory Enhancer Profiling of Mesenchymal-type Gastric Cancer Reveals Subtype-Specific Epigenomic Landscapes and Targetable Vulnerabilities

(Submitter supplied) Recent studies have highlighted mesenchymal-subtype GC (Mes-GC) as a clinically aggressive subtype with few treatment options. Genome-wide chromatin profiles of primary GCs and GC cell lines were generated to identify Mes-GC-specific enhancer landscapes. Computational analysis uncovered TEAD1 as a master regulator of Mes-GC enhancers. TEAD1 ChIP-seq and RNA-seq/H3K27ac ChIP-seq following TEAD1 knockdown was performed as validation experiments.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21290 GPL11154
163 Samples

Download data: BW, RESULTS, TXT, WIG

Series

Accession:: GSE186521

ID:: 200186521

Select item 20006373218.

CapStarr-seq: a high-throughput method for quantitative assessment of enhancer activity in mammals (ChIP-Seq)

(Submitter supplied) Here we developed CapStarr-Seq, a novel high-throughput strategy to quantitatively assess enhancer activity in mammals. This approach couples capture of regions of interest to previously developed Starr-seq technique. Extensive assessment of CapStarr-seq demonstrated accurate quantification of enhancer activity. Furthermore, we found that enhancer strength correlates with binding complexity of tissue-specific transcription factors and super-enhancers, while additive enhancer activity isolates key genes involved in cell identity and function.