GEO DataSets

(Submitter supplied) The molecular mechanisms underlying the sex differences in human muscle morphology and function remain to be elucidated. The purpose of the study was to detect the sex differences in the skeletal muscle transcriptome in both the resting state and following anabolic stimuli, resistance exericse.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

28 Samples

Download data: CEL, CHP

(Submitter supplied) The aim of this investigation was to evaluate the effect of training on the global transcriptional response of skeletal muscle to an acute bout of resistance exercise.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4894

Platform:

GPL570

14 Samples

Download data: CEL

Analysis of biceps brachii muscles from trained and untrained arms 4 hours after an acute bout of bilateral arm resistance exercise (RE). Subjects underwent a 12 week progressive unilateral arm RE training program. Results provide insight into the adaptive response of skeletal muscle to RE training.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 gender, 7 individual, 2 protocol sets

Platform:

GPL570

Series:

GSE28998

14 Samples

Download data: CEL

(Submitter supplied) Global microarray (HG U133 Plus 2.0) was used to investigate the effects of resistance exercise and resistance training on the skeletal muscle transcriptome profile of 28 young and old adults. Vastus lateralis muscle biopsies were obtained pre and 4hrs post resistance exercise in the beginning (untrained state) and at the end (trained state) of a 12 wk progressive resistance training program.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5218

Platform:

GPL570

110 Samples

Download data: CEL, CHP

(Submitter supplied) Global microarray (HG U133 Plus 2.0) was used for the first time to investigate the effects of resistance exercise on the transcriptome in slow-twitch myosin heavy chain (MHC) I and fast-twitch MHC IIa muscle fibers of young and old women. Vastus lateralis muscle biopsies were obtained pre and 4hrs post resistance exercise in the beginning (untrained state) and at the end (trained state) of a 12 wk progressive resistance training program.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5217

Platform:

GPL570

70 Samples

Download data: CEL, CHP

(Submitter supplied) Global microarray (HG U133 Plus 2.0) was used to investigate the basal level skeletal muscle transcriptome profile of young and old adults. One vastus lateralis muscle biopsy was obtained in the basal state from 36 different subjects.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5216

Platform:

GPL570

36 Samples

Download data: CEL, CHP

Analysis of vastus lateralis muscle biopsy samples from young (about 24 years old) and old (about 84 years old) adults before and after 12 weeks of progressive resistance training. Results provide insight into the molecular adaptation of the young and old skeletal muscle to resistance training.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age, 2 gender, 4 time sets

Platform:

GPL570

Series:

GSE28422

110 Samples

Download data: CEL, CHP

Analysis of slow-twitch MHC I and fast-twitch MHC IIa muscle fibers from young and old women before and after 12 weeks of progressive resistance training. Fibers obtained from vastus lateralis. Results provide insight into the molecular adaptation of young and old MHC I and IIa fibers to exercise.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age, 14 individual, 4 time, 2 tissue sets

Platform:

GPL570

Series:

GSE28392

70 Samples

Download data: CEL, CHP

Analysis of vastus lateralis muscle biopsy samples from young (about 25 years old) and old (about 78 years old) adults. Subjects had not taken part in formal exercise. Results provide insight into the effect of age on basal gene expression in the skeletal muscle.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age, 2 gender sets

Platform:

GPL570

Series:

GSE25941

36 Samples

Download data: CEL, CHP

(Submitter supplied) Unconditioned thoroughbred geldings were exercised to maximal heart rate or fatigue on an equine high-speed treadmill. Skeletal muscle biopsies were taken from the middle gluteal muscle before, immediately after and four hours after exercise. 

Organism:

Equus caballus

Type:

Expression profiling by array

Platform:

GPL8582

32 Samples

Download data: GPR

(Submitter supplied) While acute aerobic and resistance exercise stimulate a number of shared genes, each exercsie mode stimlutes a number of uniquely responsive genes, thus highlighting that different forms of exercise facilitate distinct molecular responses in skeletal muscle.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

29 Samples

Download data: TXT

(Submitter supplied) We sought to ascertain the time-course of transcriptional events that occur in human skeletal muscle at the outset of resistance exercise (RE) training in RE naïve individuals, and determine if the magnitude of any response was associated with exercise induced muscle damage. Sixteen RE naïve males were recruited, 8 underwent 2 sessions of 5x30 maximum, isokinetic knee extensions (180°.s-1) separated by 48 hrs. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4820

Platform:

GPL570

45 Samples

Download data: CEL

Analysis of vastus lateralis biopsies taken at the outset (day 1, 2 and 4) of concentric resistance exercise (RE) training in RE naive individuals. Results provide insight into molecular mechanisms underlying the initial transient response of skeletal muscle to concentric RE.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 protocol, 3 time sets

Platform:

GPL570

Series:

GSE45426

45 Samples

Download data: CEL

(Submitter supplied) 10 male subjects performed ~45 min one-legged cycling and 4 x 7 maximal concentric-eccentric knee extensions for each leg 15 min later. Thus, one limb performed aerobic and resistance exercise (AE+RE), while the opposing leg did resistance exercise only (RE). Biopsies were obtained from m. vastus lateralis of each leg 3 h after the resistance exercise bout. Gene expression analysis was carried out on the Affymetrix HuGene-2.1-st platform.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17692

20 Samples

Download data: CEL

(Submitter supplied) The aim of this study was to elucidate the transcriptional signatures that distinguish the endurance-trained and the untrained muscle in healthy adult young males, both at baseline as well as in response to an acute bout of exercise.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13667

48 Samples

Download data: CEL

(Submitter supplied) Overall, the widely disparate transcriptomes identified prior to RT among the three clusters support the notion that at least some of the inter-individual heterogeneity in propensity for RT-induced myofiber hypertrophy is likely pre-determined.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

44 Samples

Download data: TXT

(Submitter supplied) The skeletal muscle system plays an important role in the independence of older adults. In this study we examine differences in the skeletal muscle transcriptome between healthy young and older subjects and (pre‐)frail older adults. Additionally, we examine the effect of resistance‐type exercise training on the muscle transcriptome in healthy older subjects and (pre‐)frail older adults. Baseline transcriptome profiles were measured in muscle biopsies collected from 53 young, 73 healthy older subjects, and 61 frail older subjects. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20880

259 Samples

Download data: CEL

(Submitter supplied) Skeletal muscle adapts to resistance exercise (RE) performance acutely and chronically. An important regulatory step of muscle adaptation to RE is gene expression. Microarray analysis can be used as an exploratory method to investigate how genes and gene clusters are modulated acutely and chronically by RE. The purpose of the present study was to investigate the effect of training status in the basal (rested) and pre- to 24h post-RE on the global transcriptome in vastus lateralis muscle biopsies of young men. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

40 Samples

Download data: IDAT, TXT

(Submitter supplied) This study measured the transcriptome-wide response in skeletal muscle and circulating extracellular vesicles (EVs) in young adults randomized to a single exposure of TRAD (n=21, 12M/9F, 22±3y) or HITT (n=19, 11M/8F, 22±2y) exercise. Next-generation sequencing captured small (<200nt), long (>200nt), and circular RNA species in muscle and EVs. In parallel, data streams were analyzed to identify transcripts differentially expressed (|log2FC|>1, FDR≤0.05) immediately (h0, EVs only), h3, and h24 postexercise within and between exercise doses. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL24676 GPL16791

542 Samples

Download data: TXT

(Submitter supplied) Digital gene expression profiling was used to characterize the assembly of genes expressed in equine skeletal muscle and to identify the subset of genes that were differentially expressed following a ten month period of exercise training. The study cohort comprised 7 thoroughbred racehorses from a single training yard. Skeletal muscle biopsies were collected at rest from the gluteus medius at two time points: T1 (unconditioned), (9 +/- 0.5 months old) and T2 (conditioned) (20 +/- 0.7 months old). more...

Organism:

Equus caballus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL10300

13 Samples

Download data