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Series GSE106865 Query DataSets for GSE106865
Status Public on Sep 10, 2018
Title A longitudinal gene expression microarray analysis of skeletal muscle resistance training
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Skeletal muscle adapts to resistance exercise (RE) performance acutely and chronically. An important regulatory step of muscle adaptation to RE is gene expression. Microarray analysis can be used as an exploratory method to investigate how genes and gene clusters are modulated acutely and chronically by RE. The purpose of the present study was to investigate the effect of training status in the basal (rested) and pre- to 24h post-RE on the global transcriptome in vastus lateralis muscle biopsies of young men. Muscle biopsies of nine young men who undertook RE training for 10-wks were collected pre and 24h post-RE at the first (W1) and last (W10) weeks of training and analysed using microarray. An unaccustomed RE bout (at W1) up-regulated muscle gene transcripts related to stress (e.g., heat shock proteins), damage and inflammation, structural remodelling, protein turnover and increased translational capacity. Trained muscles (at W10) became more efficient metabolically, as training favoured a more oxidative metabolism, refined response to stress, showed by genes suppression related to RE-induced stress and inflammation, and up-regulated genes indicating greater muscle contractile efficiency and contribution to promote muscle growth and development. These data highlight that chronic repetition of RE increases muscle efficiency and adapt muscles to respond more specifically and accurately to RE-induced stress.
 
Overall design A total of 36 skeletal muscle biopsies of nine young men who undertook RE training for 10-wks were collected pre and 24h post-RE at the first and last weeks of training and analysed using microarray.
 
Contributor(s) Damas F, Ugrinowitsch C, Libardi CA, Jannig PR, Hector AJ, McGlory C, Lixandrão ME, Vechin FC, Montenegro H, Tricoli V, Roschel H, Phillips SM
Citation(s) 30196447
Submission date Nov 14, 2017
Last update date Dec 10, 2018
Contact name Carlos Ugrinowitsch
Organization name Escola de Educação Física e Esporte - USP
Department Departamento de Esporte
Lab Laboratório de Adaptação ao Treinamento de Força
Street address Av. Prof. Mello Moraes, 65. Cidade Universitária, Butantã.
City São Paulo
State/province SP
ZIP/Postal code 05508-030
Country Brazil
 
Platforms (1)
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
Samples (40)
GSM2856160 Vastus_lateralis_muscle_male_1_untrained_pre
GSM2856161 Vastus_lateralis_muscle_male_1_untrained_pos
GSM2856162 Vastus_lateralis_muscle_male_1_trained_pre
Relations
BioProject PRJNA418281

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE106865_Non-normalized_data.txt.gz 15.9 Mb (ftp)(http) TXT
GSE106865_RAW.tar 90.3 Mb (http)(custom) TAR (of IDAT)
Processed data included within Sample table
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