Similar studies for GEO DataSets (Select 200018476) - GEO DataSets

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Items: 20

Select item 2000184761.

Gene Expression Data from U937T:PLZF-RARa Inducible Cells

(Submitter supplied) The PLZF-RARa fusion oncoprotein is overexpressed in the t(11;17) subtype of acute promyelocytic leukemia. Gene expression microarrays were used to identify genes involved in leukemic transformation. We used microarray to detect gene expression changes induced by the PLZF-RARa fusion oncoprotein in the U937 cell line

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE18476

ID:: 200018476

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000085102.

RARα-PLZF overcomes PLZF-mediated repression of CRABPI contributing to retinoid resistance in t(11;17) APL

(Submitter supplied) This study supports an active role for PLZF and RARα-PLZF in leukemogenesis, identifies upregulation of CRABPI as a novel mechanism contributing to retinoid resistance and reveals the ability of the reciprocal fusion gene products to mediate distinct epigenetic effects contributing to the leukemic phenotype. Keywords: Disease state analysis

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
5 Samples

Download data: CEL, CHP

Series

Accession:: GSE8510

ID:: 200008510

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000956373.

Expression data from NB4 control shRNA cells and NB4 TRIB3 shRNA cells

(Submitter supplied) To identify the top 20 up-regulated genes in NB4 TRIB3 shRNA cells in comparison with NB4 control shRNA cells, we examined the microarray gene expression profile of these groups above. Despite the fact that combined therapy of all-trans retinoic acid (ATRA) with arsenic trioxide (ATO) or chemotherapy dramatically improves the prognosis of patients with acute promyelocytic leukemia (APL), these regimens can cause systemic infections and secondary leukemias. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL18943
6 Samples

Download data: PAIR

Series

Accession:: GSE95637

ID:: 200095637

Select item 2000900624.

Expression data from healthy donors and AML patients

(Submitter supplied) To identify the top 20 up-regulated genes in CD34+ cells from AML patients in comparison with healthy donors, we examined the microarray gene expression profile of CD34+ blasts from patients with newly diagnosed AML vs CD34+ normal cells from healthy donors. Despite the fact that combined therapy of all-trans retinoic acid (ATRA) with arsenic trioxide (ATO) or chemotherapy dramatically improves the prognosis of patients with APL, these regimens can cause systemic infections and secondary leukemias. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15207
6 Samples

Download data: CEL

Series

Accession:: GSE90062

ID:: 200090062

Select item 2000126415.

Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.

(Submitter supplied) A global view of PML-RARα transcriptional functions was obtained by genome-wide binding and chromatin modification analyses, combined with genome wide expression data. Complete Abstract: The translocation t(15;17) generates the chimeric PML-RARα transcription factor that is the initiating event of acute promyelocytic leukemia. A global view of PML-RARα transcriptional functions was obtained by genome-wide binding and chromatin modification analyses, combined with genome wide expression data. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array

Platforms:: GPL2040 GPL6442 GPL6441
98 Samples

Download data: GPR

Series

Accession:: GSE12641

ID:: 200012641

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000421196.

DNA methylation changes are a late event in Acute Promyelocytic Leukemia and coincide with loss of transcription factor binding

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by genome tiling array

4 related Platforms
61 Samples

Download data: TXT

Series

Accession:: GSE42119

ID:: 200042119

Select item 2000421187.

DNA methylation changes are a late event in Acute Promyelocytic Leukemia and coincide with loss of transcription factor binding (Illumina Methylation)

(Submitter supplied) The origin of aberrant DNA methylation in cancer remains largely unknown. In this study, we elucidated the DNA methylome in primary Acute Promyelocytic Leukemia (APL) and the role of PML-RARa in establishing these patterns. APL patients showed increased genome-wide DNA methylation with higher variability than healthy CD34+ cells, promyelocytes and remission bone marrow. A core set of differentially methylated regions in APL was identified. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
10 Samples

Download data: TSV

Series

Accession:: GSE42118

ID:: 200042118

Select item 2000420448.

DNA methylation changes are a late event in Acute Promyelocytic Leukemia and coincide with loss of transcription factor binding (sequencing)

Organism:: Mus musculus; Homo sapiens

Type:: Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL15456 GPL11154 GPL16173
51 Samples

Download data: TXT

Series

Accession:: GSE42044

ID:: 200042044

PubMed Similar studies SRA Run Selector

Select item 2001742479.

Transcriptomic analysis (RNA-seq) of Lin- BM cells from wild type C57 BM mice and GFP+ BM cells from TBLR1-RARa mice

(Submitter supplied) Purpose: The goal of this study is to decipher the molecular basis of TBLR1-RARa-expressing APL and to explore potential treatment target based on NGS-derived transcriptome profiling (RNA-seq) Methods: RNA-seq was performed to analyze differential gene expression between GFP+ cells from BM of TBLR1-RARa mice (TR1 and TR9) and lin- cells from BM of control mice (Control). Results: Transcriptome profiling associates with leukemic phenotype and predicts HDACi response in TR-induced APL. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
3 Samples

Download data: TXT

Series

Accession:: GSE174247

ID:: 200174247

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003025410.

Chromatin accessibility, p300 and histone acetylation define PML-RARalpha- and AML1-ETO-binding sites

(Submitter supplied) Chromatin accessibility is a key determinant of cell-type-specific gene expression. Here, we have investigated the chromatin architecture of different acute myeloid leukemia (AML) cells and the changes in accessibility when NB4 (APL) cells undergo the process of differentiation.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
25 Samples

Download data: BED, WIG

Series

Accession:: GSE30254

ID:: 200030254

PubMed Similar studies SRA Run Selector

Select item 20005325911.

Retinoid induced differentiation of NB4 APL leukemic cells

(Submitter supplied) We report the use of RNAseq to determine genomewide transcriptional changes induced by all-trans retinoic acid differentiation of NB4 acute promyelocytic leukemia (APL) cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15433
4 Samples

Download data: TXT

Series

Accession:: GSE53259

ID:: 200053259

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20005325812.

The role of TFEB in retinoid induced differentiation of NB4 APL leukemic cells (shTFEB)

(Submitter supplied) We report the use of RNAseq to determine the role of the TFEB transcription factor in all-trans retinoic acid induced differentiation of NB4 acute promyelocytic leukemia (APL) cells. We used lentiviral mediated shRNA approaches to functionally deplete TFEB in NB4 cells and compared the transcriptomes of wild type, scramble control shRNA and shTFEB knockdown cells treated with ethanol (control) versus all-trans retinoic acid for 72 hours.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15433
8 Samples

Download data: TXT

Series

Accession:: GSE53258

ID:: 200053258

Select item 20004853913.

Gene expression profiling of LT-HSCs and ST-HSCs conditionally expressing MLL-ENL

(Submitter supplied) We have developed a new conditional transgenic mouse showing that MLL-ENL, at an endogenous-like expression level, induces leukemic transformation selectively in LT-HSCs. To investigate the molecular mechanism of leukemic transformation in LT-HSCs conditionally expressing MLL-ENL, we preliminarily performed comprehensive gene expression profiling of CreER-transduced LT-HSCs and ST-HSCs using cDNA microarray analysis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
4 Samples

Download data: CEL

Series

Accession:: GSE48539

ID:: 200048539

Select item 20001920314.

PML-RARa binding sites and their correlation with the gene expression in ATRA treated NB4 cells

(Submitter supplied) PML-RARa contributes to the development of APL through repression of genes important in myeloid development. Through a global approach, we have identified 2,979 high quality PML-RARa binding sites in ZnSO4 induced PR9 cells. By integration the gene expression data, we found that PML/RARa target genes are transcriptionally suppressed in primary APL cells and re-activated in ATRA treated NB4 cells. This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array; Expression profiling by array

Platforms:: GPL570 GPL5082
7 Samples

Download data: BAR, BED, CEL, TXT

Series

Accession:: GSE19203

ID:: 200019203

Select item 20001920215.

Genome-wide recognition of PML/RARa binding sites

(Submitter supplied) PML/RARa is of crucial importance in acute promyelocytic leukemia (APL) both pathologically and therapeutically. Using a genome-wide approach, we identified in vivo PML/RARa binding sites in ZnSO4 treated PR9 cells. A total of 2,979 high quality binding sites were identified, representing 1,981 unique RefSeq genes. The supplementary bed file contains all 2,979 high quality PML-RARa binding sites reported in the paper.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL5082
1 Sample

Download data: BAR, BED, CEL, TXT

Series

Accession:: GSE19202

ID:: 200019202

PubMed Similar studies

Select item 20001920116.

Expression profiling of ATRA treated NB4 cells

(Submitter supplied) NB4 is an APL derived cell line, carrying the t(15;17) translocation and expressing the PML/RARa fusion protein. Still, an important question that remains to be addressed is whether PML/RARa target genes are transcriptionally suppressed in primary APL cells and re-activated in all-trans retinoic acid (ATRA) treated NB4 cells. Gene expression of NB4 cells treated with ATRA at different time points were analyzed.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE19201

ID:: 200019201

Select item 20015183717.

PML-RARa induces dynamic changes in genome architecture during leukemic transformation

(Submitter supplied) Acute Promyelocytic Leukemia (APL) is a fatal subtype of leukemia driven by the translocation between genes encoding the Promyelocytic Leukemia (PML) protein and the Retinoic Acid Receptor alpha (RARa) protein. We use mouse hematopoietic progenitor cells expressing PML-RARa and dissect the dynamic changes in the epigenome, transcriptome and genome architecture triggered by the expression of this oncogenic transcription factor during leukemic transformation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platform:: GPL13112
51 Samples

Download data: BED, BEDGRAPH, TSV

Series

Accession:: GSE151837

ID:: 200151837

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20002921318.

Gene regulation by phosphomimetic Myc (MycD), cytosine arabinoside (AraC) and retinoic acid (RA)

(Submitter supplied) We aimed to investigate whether the previously observed synergistic effects of AraC and RA in stimulating leukemia differentiation could be at least partially dependent on Pak2-mediated phosphorylation of Myc. Genome-wide analysis of NB4 cells treated with RA, AraC with RA, or MycD with RA revealed a significant 60% overlap between RA-target genes superactivated by AraC with RA, or MycD with RA, with respect to RA alone.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10332
19 Samples

Download data: TXT

Series

Accession:: GSE29213

ID:: 200029213

Select item 20002473119.

Gene regulation by phosphomimetic Myc and retinoic acid

(Submitter supplied) We aimed to investigate the E-box and Max-independent functions of the oncogene Myc in gene regulation and differentiation of leukemic cells. Expression in HL60 leukemic cells of a mutant form of Myc with impaired Max and E-box interaction by replacing the phosphorylation sites of Pak2 kinase to aspartic acid (MycD), resulted in downregulation of 235 genes and, interestingly, upregulation of 586 genes. more...