GEO DataSets

(Submitter supplied) Proteus mirabilis is a primary cause of complicated urinary tract infections (UTI). Surprisingly, iron acquisition systems have been poorly characterized in this uropathogen despite the urinary tract being iron-limited. In this report the transcriptome of strain HI4320, cultured under iron limitation, was examined using microarray analysis. Of genes upregulated at least 2-fold, 45 were statistically significant and comprise 21 putative iron-regulated systems. more...

Organism:

Proteus mirabilis HI4320

Type:

Expression profiling by array

Platform:

GPL9078

5 Samples

Download data: CSV

(Submitter supplied) The enteric bacterium Proteus mirabilis is a common cause of complicated urinary tract infections. In the study, microrarrays were used to analyze P. mirabilis gene expression in vivo from experimentally infected mice. Urine was collected at 1, 3, and 7d postinfection, and RNA was isolated from bacteria in the urine for transcriptional analysis. Across 9 microarrays, 471 genes were upregulated and 82 were downregulated in vivo compared to in vitro broth culture. more...

Organism:

Proteus mirabilis; Proteus mirabilis HI4320

Type:

Expression profiling by array

Platform:

GPL9078

9 Samples

Download data: MEV

(Submitter supplied) Proteus mirabilis is a leading cause of catheter-associated urinary tract infections (UTIs) and urolithiasis. The transcriptional regulator MrpJ inversely modulates two critical aspects of P. mirabilis UTI progression: fimbria-mediated attachment to the urinary tract, and flagella-mediated motility. Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) was used for the first time in a CAUTI pathogen to probe for in vivo direct targets of MrpJ. more...

Organism:

Proteus mirabilis

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL23167

8 Samples

Download data: GFF

(Submitter supplied) Serratia marcescens is a bacterium frequently found in the environment, but over the last several decades it has evolved into a concerning clinical pathogen, causing fatal bacteremia. To establish such infections, pathogens require specific nutrients; one very limited but essential nutrient is iron. We sought to characterize the iron acquisition systems in S. marcescens isolate UMH9, which was recovered from a clinical bloodstream infection. more...

Organism:

Serratia marcescens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28109

4 Samples

Download data: XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Proteus mirabilis HI4320

Type:

Expression profiling by array

Platform:

GPL9078

10 Samples

Download data: CSV

(Submitter supplied) Swarming motility by the urinary tract pathogen Proteus mirabilis has been a long-studied, but little understood phenomenon. On agar, a P. mirabilis colony grows outward in a bullseye pattern formed by consecutive waves of rapid swarming followed by consolidation into shorter cells. To examine differential gene expression in these growth phases, a microarray, constructed based on the completed genome sequence and annotation, was undertaken. more...

Organism:

Proteus mirabilis HI4320

Type:

Expression profiling by array

Platform:

GPL9078

5 Samples

Download data: CSV

(Submitter supplied) Swarming motility by the urinary tract pathogen Proteus mirabilis has been a long-studied, but little understood phenomenon. On agar, a P. mirabilis colony grows outward in a bullseye pattern formed by consecutive waves of rapid swarming followed by consolidation into shorter cells. To examine differential gene expression in these growth phases, a microarray, constructed based on the completed genome sequence and annotation, was undertaken. more...

Organism:

Proteus mirabilis HI4320

Type:

Expression profiling by array

Platform:

GPL9078

5 Samples

Download data: CSV

(Submitter supplied) A. baumannii ATCC 17978 cells were incubated under iron replete (mueller-hinton) and iron limiting (MH + 200 µM 2,2'-dipyridyl) conditions, total RNA was extracted when cultures reached OD600=0.7.

Organism:

Acinetobacter baumannii

Type:

Expression profiling by array

Platform:

GPL11113

4 Samples

Download data: TXT