Similar studies for GEO DataSets (Select 200003141) - GEO DataSets

Select item 2000031411.

(Submitter supplied) Signatures of Oncogenic Pathway Deregulation in Human Cancers. The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance to the analysis of cellular signaling pathways central to the oncogenic process. With this focus, we have developed a series of gene expression signatures that reliably reflect the activation status of several oncogenic pathways. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
111 Samples

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Series

Accession:: GSE3141

ID:: 200003141

Select item 2000031582.

Mouse Tumor Dataset

(Submitter supplied) previously published mouse data Pubmed IDS: 12754511, 12839964 Keywords: disease state analysis

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL75 GPL76
56 Samples

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Series

Accession:: GSE3158

ID:: 200003158

Select item 2000031563.

Breast Cancer Cell Lines

(Submitter supplied) Gene expression analysis on growing breast cancer cell lines. Keywords: cancer cell line profiles

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
19 Samples

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Series

Accession:: GSE3156

ID:: 200003156

Select item 2000031514.

Oncogene Signature Dataset

(Submitter supplied) Signatures of Oncogenic Pathway Deregulation in Human Cancers The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance to the analysis of cellular signaling pathways central to the oncogenic process. With this focus, we have developed a series of gene expression signatures that reliably reflect the activation status of several oncogenic pathways. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
55 Samples

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Series

Accession:: GSE3151

ID:: 200003151

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000031495.

Ovarian Cancer Dataset

(Submitter supplied) Signatures of Oncogenic Pathway Deregulation in Human Cancers. The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance to the analysis of cellular signaling pathways central to the oncogenic process. With this focus, we have developed a series of gene expression signatures that reliably reflect the activation status of several oncogenic pathways. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
153 Samples

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Series

Accession:: GSE3149

ID:: 200003149

Select item 2000031436.

Breast Cancer Dataset

(Submitter supplied) Signatures of Oncogenic Pathway Deregulation in Human Cancers. The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance to the analysis of cellular signaling pathways central to the oncogenic process. With this focus, we have developed a series of gene expression signatures that reliably reflect the activation status of several oncogenic pathways. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL8300
158 Samples

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Series

Accession:: GSE3143

ID:: 200003143

Select item 2000287397.

Gene expression patterns of chemoresistant and chemosensitive serous epithelial ovarian tumors with possible predictive value in response to initial chemotherapy

(Submitter supplied) Chemotherapy (CT) resistance in ovarian cancer is broad and encompasses diverse, unrelated drugs, suggesting more than one mechanism of resistance. We aimed to analyze the gene expression patterns in primary serous epithelial ovarian cancer (EOC) samples displaying different responses to first-line CT in an attempt to identify specific molecular signatures associated with response to CT. Initially, the expression profiles of 15 chemoresistant serous EOC tumors [time to recurrence (TTR) ≤6 months] and 10 chemosensitive serous EOC tumors (TTR ≥30 months) were independently analyzed which allowed the identification of specific sets of differentially expressed genes that might be functionally implicated in the evolution of the chemoresistant or the chemosensitive phenotype. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL7264
50 Samples

Download data: TXT

Series

Accession:: GSE28739

ID:: 200028739

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000089578.

Revealing Targeted Therapy for Human Cancer by Gene Module Maps

(Submitter supplied) A major goal of cancer research is to match specific therapies to molecular targets in cancer. Genome-scale expression profiling has identified new subtypes of cancer based on consistent patterns of variation in gene expression, leading to improved prognostic predictions. However, how these new genetic subtypes of cancers should be treated is unknown. Here we show that a gene module map can guide the prospective identification of targeted therapies for genetic subtypes of cancer. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5804
6 Samples

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Series

Accession:: GSE8957

ID:: 200008957

Select item 2000053079.

Using breast (cancer) cell lines to measure bortezomib therapy response

(Submitter supplied) Revealing targeted therapy for human cancer by gene module maps A major goal of cancer research is to match specific therapies to molecular targets in cancer. Genome-scale expression profiling has identified new subtypes of cancer based on consistent patterns of variation in gene expression, leading to improved prognostic predictions. However, how these new genetic subtypes of cancers should be treated is unknown. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL3676
33 Samples

Download data: TXT

Series

Accession:: GSE5307

ID:: 200005307

Select item 20001518110.

Expression profiles of cancer cells with anchorage-independent growth ability

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL570 GPL1261
56 Samples

Download data: CEL

Series

Accession:: GSE15181

ID:: 200015181

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001516111.

Expression data from retroviral vector-infected immortalized mouse embryonic fibroblasts (MEFs)

(Submitter supplied) Cultured cancer cells exhibit substantial phenotypic heterogeneity when measured in a variety of ways such as sensitivity to drugs or the capacity to grow under various conditions. Among these, the ability to exhibit anchorage-independent cell growth (colony forming capacity in semisolid media) has been considered to be fundamental in cancer biology because it has been connected with tumor cell aggressiveness in vivo such as tumorigenic and metastatic potentials, and also utilized as a marker for in vitro transformation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
26 Samples

Download data: CEL

Series

Accession:: GSE15161

ID:: 200015161

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001502612.

Expression data from breast cancer cell lines with various colony-forming ability

(Submitter supplied) Cultured cancer cells exhibit substantial phenotypic heterogeneity when measured in a variety of ways such as sensitivity to drugs or the capacity to grow under various conditions. Among these, the ability to exhibit anchorage-independent cell growth (colony forming capacity in semisolid media), has been considered to be fundamental in cancer biology, because it has been connected with tumor cell aggressiveness in vivo such as tumorigenic and metastatic potentials, and also utilized as a marker for in vitro transformation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
30 Samples

Download data: TXT

Series

Accession:: GSE15026

ID:: 200015026

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008308313.

RNA-Seq data for AKT, BAD, ERBB2, IGF1R, RAF1 and KRAS(G12V) overexpressed samples with twelve green fluorescent protein control samples using human mammary epithelial cells

(Submitter supplied) The goal was to capture the transcriptional activity due to over-expression of AKT, BAD, ERBB2, IGF1R, RAF1 and KRAS(G12V) genes .Overexpressions were validated using Western Blots. Illumina RNA-Seq technology was used to capture the downstream transcriptional activity. Reads were 101 base pairs long and single ended. An R open source package “Rsubread” was used to align and quantify the read using UCSC hg19 annotation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
59 Samples

Download data: TXT

Series

Accession:: GSE83083

ID:: 200083083

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20001369614.

Copy number profiling of 45 human breast cancer cell lines on Affymetrix 100K SNP arrays

(Submitter supplied) Breast cancer cell lines grown in full serum under standard conditions were profiled on Affymetrix GeneChip Mapping 100K Set Arrays Keywords: Mapping Array

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platforms:: GPL2004 GPL2005
90 Samples

Download data: CEL

Series

Accession:: GSE13696

ID:: 200013696

PubMed Similar studies

Select item 20000784915.

Age-Specific Differences of Oncogenic Pathway Deregulation Seen in Human Breast Tumors

(Submitter supplied) Breast cancer arising in young women has a poorer prognosis, is less likely to be hormone sensitive, and represents a particularly challenging clinical entity. The biology driving the aggressive nature of breast cancer arising in young women has yet to be defined. Among 784 patients with early stage breast cancer, using prospectively-defined, age-specific cohorts (young <= 45 years; older >= 65 years), 411 eligible patients (n = 200 < 45 years; n = 211 >= 65 years) with clinically-annotated Affymetrix microarray data were identified. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL8300
78 Samples

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Series

Accession:: GSE7849

ID:: 200007849

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000866616.

Integrated SV40 T/t-antigen Cancer Signature in Aggressive Breast, Prostate and Lung Carcinomas with Poor Prognosis

(Submitter supplied) Understanding the genetic architecture of cancer pathways that distinguishes subsets of human cancer is critical to developing new therapies that better target tumors based upon their molecular expression profiles. In this study, we identify an integrated gene signature from multiple transgenic models of epithelial cancers intrinsic to the functions of the Simean virus 40 T/t-antigens that is associated with the biologic behavior and prognosis for several human epithelial tumors. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5339
73 Samples

Download data: TXT

Series

Accession:: GSE8666

ID:: 200008666

Select item 20000866317.

Integrated SV40 T/t-antigen Cancer Signature in Aggressive Breast, Prostate and Lung Carcinomas with Poor Prognosis 2

(Submitter supplied) Understanding the genetic architecture of cancer pathways that distinguishes subsets of human cancer is critical to developing new therapies that better target tumors based upon their molecular expression profiles. In this study, we identify an integrated gene signature from multiple transgenic models of epithelial cancers intrinsic to the functions of the Simean virus 40 T/t-antigens that is associated with the biologic behavior and prognosis for several human epithelial tumors. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5339
38 Samples

Download data: TXT

Series

Accession:: GSE8663

ID:: 200008663

Select item 20000866218.

Integrated SV40 T/t-antigen Cancer Signature in Aggressive Breast, Prostate and Lung Carcinomas with Poor Prognosis 1

(Submitter supplied) Understanding the genetic architecture of cancer pathways that distinguishes subsets of human cancer is critical to developing new therapies that better target tumors based upon their molecular expression profiles. In this study, we identify an integrated gene signature from multiple transgenic models of epithelial cancers intrinsic to the functions of the Simean virus 40 T/t-antigens that is associated with the biologic behavior and prognosis for several human epithelial tumors. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5339
35 Samples

Download data: TXT

Series

Accession:: GSE8662

ID:: 200008662

Select item 20004294819.

Two New Stromal Signatures Stratify Breast Cancers with Different Prognosis

(Submitter supplied) Purpose: Multiple studies from last decades have shown that the microenvironment of carcinomas plays an important role in the initiation, progression and metastasis of cancer. Our group has previously identified novel cancer stroma gene expression signatures associated with outcome differences in breast cancer by gene expression profiling of two tumors of fibroblasts as surrogates for physiologic stromal expression patterns. more...