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Otud7a OTU domain containing 7A [ Mus musculus (house mouse) ]

Gene ID: 170711, updated on 4-Jan-2025

Summary

Official Symbol
Otud7aprovided by MGI
Official Full Name
OTU domain containing 7Aprovided by MGI
Primary source
MGI:MGI:2158505
See related
Ensembl:ENSMUSG00000033510 AllianceGenome:MGI:2158505
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Otud7
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Predicted to be involved in protein K11-linked deubiquitination and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Used to study chromosome 15q13.3 microdeletion syndrome. Orthologous to human OTUD7A (OTU deubiquitinase 7A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in cerebellum adult (RPKM 5.0), cortex adult (RPKM 4.3) and 6 other tissues See more
Orthologs
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Genomic context

See Otud7a in Genome Data Viewer
Location:
7 C; 7 34.52 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (63094493..63415980)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (63444745..63766232)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 7 Neighboring gene STARR-seq mESC enhancer starr_19001 Neighboring gene STARR-seq mESC enhancer starr_19002 Neighboring gene RIKEN cDNA 4930554H23 gene Neighboring gene STARR-seq mESC enhancer starr_19003 Neighboring gene thyroid hormone receptor associated protein 3 pseudogene Neighboring gene high mobility group box 2 pseudogene Neighboring gene NOP16 nucleolar protein homolog pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:70961406-70961515 Neighboring gene ribosomal protein S11 pseudogene Neighboring gene predicted gene, 39023 Neighboring gene uncharacterized protein C9orf85 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding  
enables K63-linked polyubiquitin modification-dependent protein binding  
enables cysteine-type deubiquitinase activity  
enables cysteine-type deubiquitinase activity  
enables cysteine-type deubiquitinase activity  
enables zinc ion binding  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
is_active_in nucleus  
located_in nucleus  

General protein information

Preferred Names
OTU domain-containing protein 7A
Names
Cezanne 2 protein
zinc finger protein Cezanne 2
NP_570950.1
XP_006540746.1
XP_011249113.1
XP_017177494.1
XP_030098045.1
XP_030098046.1
XP_030098047.1
XP_036008616.1
XP_036008617.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130880.1NP_570950.1  OTU domain-containing protein 7A

    See identical proteins and their annotated locations for NP_570950.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ430384
    Consensus CDS
    CCDS21330.1
    UniProtKB/Swiss-Prot
    Q8R554
    Related
    ENSMUSP00000057282.8, ENSMUST00000058476.14
    Conserved Domains (3) summary
    cd14347
    Location:2668
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:888911
    zf-A20; A20-like zinc finger
    cl19932
    Location:207371
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    63094493..63415980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242185.1XP_030098045.1  OTU domain-containing protein 7A isoform X1

    Conserved Domains (4) summary
    PRK07764
    Location:702884
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd14347
    Location:2668
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:895918
    zf-A20; A20-like zinc finger
    cl19932
    Location:207378
    OTU; OTU-like cysteine protease
  2. XM_030242186.1XP_030098046.1  OTU domain-containing protein 7A isoform X2

    Conserved Domains (4) summary
    PRK07764
    Location:701883
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd14347
    Location:2668
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:894917
    zf-A20; A20-like zinc finger
    cl19932
    Location:206377
    OTU; OTU-like cysteine protease
  3. XM_036152724.1XP_036008617.1  OTU domain-containing protein 7A isoform X1

    Conserved Domains (4) summary
    PRK07764
    Location:702884
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd14347
    Location:2668
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:895918
    zf-A20; A20-like zinc finger
    cl19932
    Location:207378
    OTU; OTU-like cysteine protease
  4. XM_011250811.3XP_011249113.1  OTU domain-containing protein 7A isoform X1

    See identical proteins and their annotated locations for XP_011249113.1

    Conserved Domains (4) summary
    PRK07764
    Location:702884
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd14347
    Location:2668
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:895918
    zf-A20; A20-like zinc finger
    cl19932
    Location:207378
    OTU; OTU-like cysteine protease
  5. XM_017322005.1XP_017177494.1  OTU domain-containing protein 7A isoform X2

    Conserved Domains (4) summary
    PRK07764
    Location:701883
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd14347
    Location:2668
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:894917
    zf-A20; A20-like zinc finger
    cl19932
    Location:206377
    OTU; OTU-like cysteine protease
  6. XM_030242187.2XP_030098047.1  OTU domain-containing protein 7A isoform X1

    Conserved Domains (4) summary
    PRK07764
    Location:702884
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd14347
    Location:2668
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:895918
    zf-A20; A20-like zinc finger
    cl19932
    Location:207378
    OTU; OTU-like cysteine protease
  7. XM_036152723.1XP_036008616.1  OTU domain-containing protein 7A isoform X1

    Conserved Domains (4) summary
    PRK07764
    Location:702884
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd14347
    Location:2668
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:895918
    zf-A20; A20-like zinc finger
    cl19932
    Location:207378
    OTU; OTU-like cysteine protease
  8. XM_006540683.5XP_006540746.1  OTU domain-containing protein 7A isoform X3

    Conserved Domains (3) summary
    PRK07764
    Location:649831
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam01754
    Location:842865
    zf-A20; A20-like zinc finger
    cl19932
    Location:154325
    OTU; OTU-like cysteine protease
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