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Lrrc7 leucine rich repeat containing 7 [ Mus musculus (house mouse) ]

Gene ID: 242274, updated on 27-Nov-2024

Summary

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Official Symbol
Lrrc7provided by MGI
Official Full Name
leucine rich repeat containing 7provided by MGI
Primary source
MGI:MGI:2676665
See related
Ensembl:ENSMUSG00000028176 AllianceGenome:MGI:2676665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
densin; mKIAA1365; B230334C09Rik
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; protein localization to postsynapse; and receptor clustering. Predicted to be located in actin cytoskeleton; dendritic spine; and filopodium. Predicted to be active in several cellular components, including axon initial segment; basolateral plasma membrane; and postsynaptic density membrane. Predicted to colocalize with postsynaptic membrane. Is expressed in brain; cortical plate; esophagus mesenchyme; spinal cord; and trachea mesenchyme. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human LRRC7 (leucine rich repeat containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 5.5), cortex adult (RPKM 5.0) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Lrrc7 in Genome Data Viewer
Location:
3 H4; 3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (157772823..158268254, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (158067186..158561983, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09389 Neighboring gene STARR-positive B cell enhancer ABC_E2684 Neighboring gene STARR-positive B cell enhancer mm9_chr3:157723907-157724208 Neighboring gene STARR-positive B cell enhancer ABC_E11232 Neighboring gene STARR-positive B cell enhancer ABC_E7953 Neighboring gene serine and arginine-rich splicing factor 11 Neighboring gene leucine rich repeat containing 40 Neighboring gene STARR-seq mESC enhancer starr_09391 Neighboring gene STARR-seq mESC enhancer starr_09392 Neighboring gene STARR-seq mESC enhancer starr_09393 Neighboring gene STARR-seq mESC enhancer starr_09394 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Densin is a novel cell membrane protein of Sertoli cells in the testis. Lassila M, et al. Mol Reprod Dev, 2007 May. PMID 17039495
  2. Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation. Chong CH, et al. Transl Psychiatry, 2019 Oct 3. PMID 31582721, Free PMC Article
  3. Densin-180 Controls the Trafficking and Signaling of L-Type Voltage-Gated Ca(v)1.2 Ca(2+) Channels at Excitatory Synapses. Wang S, et al. J Neurosci, 2017 May 3. PMID 28363979, Free PMC Article
  4. Ca2+-dependent facilitation of Cav1.3 Ca2+ channels by densin and Ca2+/calmodulin-dependent protein kinase II. Jenkins MA, et al. J Neurosci, 2010 Apr 14. PMID 20392935, Free PMC Article
  5. Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction. Carlisle HJ, et al. J Neurosci, 2011 Nov 9. PMID 22072671, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. important role of LRRC7 in mGluR5 signaling; mutant mice had inappropriate juvenile aggressive behavior and significant anxiety-like behavior and social dysfunction in adulthood
    Title: Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation.
  2. We report that the protein densin-180 is highly enriched at excitatory synapses in the brain and enhances the cell surface trafficking and postsynaptic localization of Cav1.2 L-type Ca(2+) channels in neurons. This interaction promotes coupling of Cav1.2 channels to activity-dependent gene transcription.
    Title: Densin-180 Controls the Trafficking and Signaling of L-Type Voltage-Gated Ca(v)1.2 Ca(2+) Channels at Excitatory Synapses.
  3. Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
    Title: Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
  4. This study demonstrated that Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction.
    Title: Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction.
  5. Densin is a novel testicular protein expressed in the cell membranes of Sertoli cells.
    Title: Densin is a novel cell membrane protein of Sertoli cells in the testis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in axon initial segment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon initial segment ISO
Inferred from Sequence Orthology
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 7
Names
densin 180

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081358.4 → NP_001074827.1  leucine-rich repeat-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001074827.1

    Status: VALIDATED

    Source sequence(s)
    AC102540, AC118595, AC134449, AC145301
    UniProtKB/TrEMBL
    A0A0G2JFZ5, E9Q6L9
    Related
    ENSMUSP00000101659.2, ENSMUST00000106044.6
    Conserved Domains (4) summary
    cd00116
    Location:166 → 406
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00992
    Location:1452 → 1537
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:31 → 52
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:144 → 199
    LRR_8; Leucine rich repeat

  2. NM_001291452.3 → NP_001278381.1  leucine-rich repeat-containing protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102540, AC118595, AC134449, AC145301
    Consensus CDS
    CCDS80073.1
    UniProtKB/Swiss-Prot
    Q80TE7
    UniProtKB/TrEMBL
    A0A0G2JDT9
    Related
    ENSMUSP00000142498.2, ENSMUST00000200137.5
    Conserved Domains (4) summary
    cd00116
    Location:166 → 406
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00992
    Location:1405 → 1490
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:31 → 52
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:144 → 199
    LRR_8; Leucine rich repeat

  3. NM_001291453.3 → NP_001278382.1  leucine-rich repeat-containing protein 7 isoform 3

    See identical proteins and their annotated locations for NP_001278382.1

    Status: VALIDATED

    Source sequence(s)
    AC102540, AC118595, AC134449, AC145301
    Consensus CDS
    CCDS80072.1
    UniProtKB/Swiss-Prot
    Q80TE7
    UniProtKB/TrEMBL
    B9EHV0
    Related
    ENSMUSP00000142440.2, ENSMUST00000199890.5
    Conserved Domains (3) summary
    COG4886
    Location:97 → 407
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:31 → 52
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:51 → 107
    LRR_8; Leucine rich repeat

  4. NM_001370781.1 → NP_001357710.1  leucine-rich repeat-containing protein 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC102540, AC118595, AC134449, AC145301
    UniProtKB/TrEMBL
    A0A0G2JFZ5
    Conserved Domains (4) summary
    COG4886
    Location:130 → 440
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1485 → 1570
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:85 → 140
    LRR_8; Leucine rich repeat

  5. NM_001370782.1 → NP_001357711.1  leucine-rich repeat-containing protein 7 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC102540, AC118595, AC134449, AC145301
    UniProtKB/Swiss-Prot
    Q80TE7
    Conserved Domains (4) summary
    COG4886
    Location:130 → 440
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1438 → 1523
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:85 → 140
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    157772823..158268254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501512.5 → XP_006501575.1  leucine-rich repeat-containing protein 7 isoform X9

    UniProtKB/TrEMBL
    A0A0G2JFZ5
    Conserved Domains (4) summary
    COG4886
    Location:130 → 440
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1335 → 1420
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:85 → 140
    LRR_8; Leucine rich repeat

  2. XM_030252624.2 → XP_030108484.1  leucine-rich repeat-containing protein 7 isoform X15

    UniProtKB/Swiss-Prot
    Q80TE7
    Conserved Domains (4) summary
    COG4886
    Location:130 → 440
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1355 → 1440
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:85 → 140
    LRR_8; Leucine rich repeat

  3. XM_006501510.5 → XP_006501573.1  leucine-rich repeat-containing protein 7 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JFZ5
    Conserved Domains (4) summary
    COG4886
    Location:130 → 440
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1402 → 1487
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:85 → 140
    LRR_8; Leucine rich repeat

  4. XM_006501508.5 → XP_006501571.1  leucine-rich repeat-containing protein 7 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JFZ5
    Conserved Domains (4) summary
    COG4886
    Location:130 → 440
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1418 → 1503
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:85 → 140
    LRR_8; Leucine rich repeat

  5. XM_017319582.3 → XP_017175071.1  leucine-rich repeat-containing protein 7 isoform X8

    UniProtKB/Swiss-Prot
    Q80TE7
    Conserved Domains (3) summary
    COG4886
    Location:130 → 440
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:85 → 140
    LRR_8; Leucine rich repeat

  6. XM_006501511.5 → XP_006501574.1  leucine-rich repeat-containing protein 7 isoform X6

    UniProtKB/Swiss-Prot
    Q80TE7
    UniProtKB/TrEMBL
    A0A571BEA5
    Related
    ENSMUSP00000158628.3, ENSMUST00000238317.3
    Conserved Domains (4) summary
    COG4886
    Location:130 → 440
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1398 → 1483
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:85 → 140
    LRR_8; Leucine rich repeat

  7. XM_036163108.1 → XP_036019001.1  leucine-rich repeat-containing protein 7 isoform X7

    UniProtKB/Swiss-Prot
    Q80TE7
    Conserved Domains (3) summary
    COG4886
    Location:130 → 440
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:84 → 140
    LRR_8; Leucine rich repeat

  8. XM_006501505.5 → XP_006501568.1  leucine-rich repeat-containing protein 7 isoform X2

    UniProtKB/Swiss-Prot
    Q80TE7
    Conserved Domains (4) summary
    COG4886
    Location:130 → 440
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1445 → 1530
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:85 → 140
    LRR_8; Leucine rich repeat

  9. XM_006501507.5 → XP_006501570.1  leucine-rich repeat-containing protein 7 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JFZ5
    Conserved Domains (3) summary
    COG4886
    Location:130 → 440
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:85 → 140
    LRR_8; Leucine rich repeat

  10. XM_030252621.2 → XP_030108481.1  leucine-rich repeat-containing protein 7 isoform X10

    UniProtKB/TrEMBL
    A0A0G2JFZ5
    Conserved Domains (4) summary
    COG4886
    Location:97 → 407
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1302 → 1387
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:31 → 52
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:52 → 107
    LRR_8; Leucine rich repeat

  11. XM_011240122.4 → XP_011238424.1  leucine-rich repeat-containing protein 7 isoform X1

    See identical proteins and their annotated locations for XP_011238424.1

    UniProtKB/TrEMBL
    A0A0G2JFZ5
    Related
    ENSMUSP00000143365.2, ENSMUST00000200196.5
    Conserved Domains (4) summary
    COG4886
    Location:92 → 402
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1447 → 1532
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:26 → 47
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:47 → 102
    LRR_8; Leucine rich repeat

  12. XM_006501504.5 → XP_006501567.1  leucine-rich repeat-containing protein 7 isoform X1

    See identical proteins and their annotated locations for XP_006501567.1

    UniProtKB/TrEMBL
    A0A0G2JFZ5
    Conserved Domains (4) summary
    COG4886
    Location:92 → 402
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1447 → 1532
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:26 → 47
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:47 → 102
    LRR_8; Leucine rich repeat

  13. XM_011240123.3 → XP_011238425.1  leucine-rich repeat-containing protein 7 isoform X11

    Conserved Domains (3) summary
    COG4886
    Location:5 → 223
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1268 → 1353
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:7 → 29
    LRR_RI; leucine-rich repeat [structural motif]

  14. XM_036163109.1 → XP_036019002.1  leucine-rich repeat-containing protein 7 isoform X13

    Conserved Domains (1) summary
    cd00992
    Location:744 → 829
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  15. XM_011240124.4 → XP_011238426.1  leucine-rich repeat-containing protein 7 isoform X12

    Conserved Domains (1) summary
    cd00992
    Location:811 → 896
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  16. XM_030252622.2 → XP_030108482.1  leucine-rich repeat-containing protein 7 isoform X14

    Conserved Domains (3) summary
    COG4886
    Location:130 → 440
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:85 → 140
    LRR_8; Leucine rich repeat

RNA

  1. XR_003954326.2 RNA Sequence

  2. XR_004941324.1 RNA Sequence

  3. XR_004941323.1 RNA Sequence

  4. XR_004941322.1 RNA Sequence

  5. XR_004941325.1 RNA Sequence

  6. XR_004941326.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TE7.2 GenPept UniProtKB/Swiss-Prot:Q80TE7

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