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Cdc42bpa CDC42 binding protein kinase alpha [ Mus musculus (house mouse) ]

Gene ID: 226751, updated on 27-Nov-2024

Summary

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Official Symbol
Cdc42bpaprovided by MGI
Official Full Name
CDC42 binding protein kinase alphaprovided by MGI
Primary source
MGI:MGI:2441841
See related
Ensembl:ENSMUSG00000026490 AllianceGenome:MGI:2441841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DMPK-like; A930014J19Rik
Summary
Predicted to enable several functions, including ATP binding activity; identical protein binding activity; and magnesium ion binding activity. Acts upstream of or within microtubule cytoskeleton organization and nuclear migration. Located in lamellipodium. Is expressed in cerebellum. Orthologous to human CDC42BPA (CDC42 binding protein kinase alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 17.3), cortex adult (RPKM 15.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Cdc42bpa in Genome Data Viewer
Location:
1 H4; 1 84.01 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (179787058..179993171)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (179960079..180165606)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 28 Neighboring gene AT hook containing transcription factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E3340 Neighboring gene STARR-positive B cell enhancer ABC_E5865 Neighboring gene STARR-seq mESC enhancer starr_03185 Neighboring gene predicted gene, 31668 Neighboring gene STARR-seq mESC enhancer starr_03186 Neighboring gene STARR-seq mESC enhancer starr_03187 Neighboring gene predicted gene, 50608 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182105294-182105595 Neighboring gene predicted gene, 38331 Neighboring gene STARR-positive B cell enhancer ABC_E2024 Neighboring gene STARR-positive B cell enhancer ABC_E1237 Neighboring gene STARR-seq mESC enhancer starr_03189 Neighboring gene coenzyme Q8A Neighboring gene predicted gene, 57491 Neighboring gene predicted gene, 37336

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MRCK activates mouse oocyte myosin II for spindle rotation and male pronucleus centration. Bourdais A, et al. J Cell Biol, 2023 Nov 6. PMID 37651121, Free PMC Article
  2. Myotonic dystrophy kinase-related CDC42-binding kinase α, a new transferrin receptor type 2-binding partner, is a regulator of erythropoiesis. Richard C, et al. Am J Hematol, 2021 Apr 1. PMID 33476437
  3. Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. Gomes ER, et al. Cell, 2005 May 6. PMID 15882626
  4. Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics. Lee ICJ, et al. J Biol Chem, 2014 Sep 26. PMID 25107909, Free PMC Article
  5. DNA methylation in the pathophysiology of hyperphenylalaninemia in the PAH(enu2) mouse model of phenylketonuria. Dobrowolski SF, et al. Mol Genet Metab, 2016 Sep. PMID 26822703, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MRCK activates mouse oocyte myosin II for spindle rotation and male pronucleus centration.
    Title: MRCK activates mouse oocyte myosin II for spindle rotation and male pronucleus centration.
  2. Myotonic dystrophy kinase-related CDC42-binding kinase alpha, a new transferrin receptor type 2-binding partner, is a regulator of erythropoiesis.
    Title: Myotonic dystrophy kinase-related CDC42-binding kinase α, a new transferrin receptor type 2-binding partner, is a regulator of erythropoiesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC189823

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actomyosin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actomyosin ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase MRCK alpha
Names
myotonic dystrophy kinase-related CDC-42-binding kinase-alpha
NP_001028457.1
NP_001333733.1
NP_001333734.1
NP_001346470.1
NP_001346471.1
NP_001346472.1
NP_001346473.1
NP_001346474.1
NP_001346475.1
NP_001346476.1
NP_001346477.1
NP_001346478.1
XP_006496865.1
XP_006496866.1
XP_006496867.1
XP_006496869.1
XP_006496870.1
XP_006496872.1
XP_011237104.1
XP_011237105.1
XP_011237106.1
XP_017175608.1
XP_017175618.1
XP_017175619.1
XP_030109369.1
XP_030109370.1
XP_036020077.1
XP_036020080.1
XP_036020088.1
XP_036020093.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033285.1 → NP_001028457.1  serine/threonine-protein kinase MRCK alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Consensus CDS
    CCDS48466.1
    UniProtKB/TrEMBL
    B2RXX8, E9PVY0
    Related
    ENSMUSP00000106746.2, ENSMUST00000111117.8
    Conserved Domains (8) summary
    pfam08826
    Location:881 → 941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77 → 343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:482 → 782
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:1072 → 1206
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:1013 → 1063
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1232 → 1496
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  2. NM_001346804.1 → NP_001333733.1  serine/threonine-protein kinase MRCK alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Consensus CDS
    CCDS83649.1
    UniProtKB/Swiss-Prot
    B2RY49, Q3UU96, Q4V9U7, Q6ZQA9, Q8R495
    UniProtKB/TrEMBL
    B2RXX8
    Related
    ENSMUSP00000095059.4, ENSMUST00000097450.10

  3. NM_001346805.1 → NP_001333734.1  serine/threonine-protein kinase MRCK alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Consensus CDS
    CCDS83650.1
    UniProtKB/TrEMBL
    B2RXX8, H7BX44
    Related
    ENSMUSP00000075980.6, ENSMUST00000076687.12

  4. NM_001359541.1 → NP_001346470.1  serine/threonine-protein kinase MRCK alpha isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442 → 941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1059 → 1193
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:1000 → 1050
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1219 → 1483
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  5. NM_001359542.1 → NP_001346471.1  serine/threonine-protein kinase MRCK alpha isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Consensus CDS
    CCDS87933.1
    UniProtKB/TrEMBL
    A0A1D5RLQ9, B2RXX8
    Related
    ENSMUSP00000148469.2, ENSMUST00000212756.2
    Conserved Domains (6) summary
    COG0419
    Location:442 → 941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1088 → 1222
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:1029 → 1079
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1248 → 1512
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  6. NM_001359543.1 → NP_001346472.1  serine/threonine-protein kinase MRCK alpha isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442 → 941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1075 → 1209
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:1016 → 1066
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1235 → 1499
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  7. NM_001359544.1 → NP_001346473.1  serine/threonine-protein kinase MRCK alpha isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    pfam08826
    Location:800 → 860
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:442 → 861
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:978 → 1112
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:919 → 969
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1138 → 1402
    CNH; CNH domain

  8. NM_001359545.1 → NP_001346474.1  serine/threonine-protein kinase MRCK alpha isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    D3YYN8
    Conserved Domains (6) summary
    COG0419
    Location:442 → 941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1039 → 1173
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:980 → 1030
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1199 → 1463
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  9. NM_001359546.1 → NP_001346475.1  serine/threonine-protein kinase MRCK alpha isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:373 → 872
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1003 → 1137
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:6 → 336
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:944 → 994
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1163 → 1427
    CNH; CNH domain
    pfam15796
    Location:461 → 539
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  10. NM_001359547.1 → NP_001346476.1  serine/threonine-protein kinase MRCK alpha isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (7) summary
    smart00285
    Location:1483 → 1517
    PBD; P21-Rho-binding domain
    COG0419
    Location:338 → 837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:984 → 1118
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1 → 301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:925 → 975
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1144 → 1408
    CNH; CNH domain
    pfam15796
    Location:426 → 504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  11. NM_001359548.1 → NP_001346477.1  serine/threonine-protein kinase MRCK alpha isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (7) summary
    smart00285
    Location:1470 → 1504
    PBD; P21-Rho-binding domain
    COG0419
    Location:338 → 837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:971 → 1105
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1 → 301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:912 → 962
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1131 → 1395
    CNH; CNH domain
    pfam15796
    Location:426 → 504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  12. NM_001359549.1 → NP_001346478.1  serine/threonine-protein kinase MRCK alpha isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    D3YYN8
    Conserved Domains (7) summary
    smart00285
    Location:1434 → 1468
    PBD; P21-Rho-binding domain
    COG0419
    Location:338 → 837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:935 → 1069
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1 → 301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:876 → 926
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1095 → 1359
    CNH; CNH domain
    pfam15796
    Location:426 → 504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

RNA

  1. NR_153194.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    179787058..179993171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238803.4 → XP_011237105.1  serine/threonine-protein kinase MRCK alpha isoform X10

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:338 → 837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:984 → 1118
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1 → 301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00780
    Location:1144 → 1408
    CNH; CNH domain
    pfam15796
    Location:426 → 504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:923 → 982
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  2. XM_030253509.2 → XP_030109369.1  serine/threonine-protein kinase MRCK alpha isoform X11

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (7) summary
    COG0419
    Location:338 → 837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00132
    Location:1465 → 1492
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cd01243
    Location:968 → 1102
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1 → 301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:909 → 959
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1128 → 1392
    CNH; CNH domain
    pfam15796
    Location:425 → 504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  3. XM_030253510.2 → XP_030109370.1  serine/threonine-protein kinase MRCK alpha isoform X12

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (7) summary
    COG0419
    Location:338 → 837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00132
    Location:1452 → 1479
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cd01243
    Location:955 → 1089
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1 → 301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:896 → 946
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1115 → 1379
    CNH; CNH domain
    pfam15796
    Location:425 → 504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  4. XM_011238804.4 → XP_011237106.1  serine/threonine-protein kinase MRCK alpha isoform X14

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (7) summary
    pfam08826
    Location:696 → 756
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:338 → 757
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00132
    Location:1400 → 1427
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cd01243
    Location:903 → 1037
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1 → 301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:844 → 894
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1063 → 1327
    CNH; CNH domain

  5. XM_017320119.3 → XP_017175608.1  serine/threonine-protein kinase MRCK alpha isoform X1

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442 → 941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1088 → 1222
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1248 → 1512
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:1027 → 1086
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  6. XM_006496802.5 → XP_006496865.1  serine/threonine-protein kinase MRCK alpha isoform X2

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442 → 941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1075 → 1209
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:1016 → 1066
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1235 → 1499
    CNH; CNH domain
    pfam15796
    Location:529 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  7. XM_006496803.5 → XP_006496866.1  serine/threonine-protein kinase MRCK alpha isoform X3

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442 → 941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1072 → 1206
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:1013 → 1063
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1232 → 1496
    CNH; CNH domain
    pfam15796
    Location:529 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  8. XM_006496804.5 → XP_006496867.1  serine/threonine-protein kinase MRCK alpha isoform X4

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442 → 943
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1062 → 1196
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:1003 → 1053
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1222 → 1486
    CNH; CNH domain
    pfam15796
    Location:529 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  9. XM_006496806.5 → XP_006496869.1  serine/threonine-protein kinase MRCK alpha isoform X5

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442 → 943
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1049 → 1183
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:990 → 1040
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1209 → 1473
    CNH; CNH domain
    pfam15796
    Location:529 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  10. XM_006496807.5 → XP_006496870.1  serine/threonine-protein kinase MRCK alpha isoform X6

    UniProtKB/TrEMBL
    D3YYN8
    Conserved Domains (6) summary
    COG0419
    Location:442 → 941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1039 → 1173
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:980 → 1030
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1199 → 1463
    CNH; CNH domain
    pfam15796
    Location:529 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  11. XM_036164184.1 → XP_036020077.1  serine/threonine-protein kinase MRCK alpha isoform X1

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442 → 941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1088 → 1222
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1248 → 1512
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:1027 → 1086
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  12. XM_006496809.5 → XP_006496872.1  serine/threonine-protein kinase MRCK alpha isoform X8

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    pfam08826
    Location:800 → 860
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:442 → 861
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1007 → 1141
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:948 → 998
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1167 → 1431
    CNH; CNH domain

  13. XM_017320129.3 → XP_017175618.1  serine/threonine-protein kinase MRCK alpha isoform X9

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    pfam08826
    Location:800 → 860
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:442 → 861
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:994 → 1128
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:935 → 985
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1154 → 1418
    CNH; CNH domain

  14. XM_017320130.3 → XP_017175619.1  serine/threonine-protein kinase MRCK alpha isoform X10

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:338 → 837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:984 → 1118
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1 → 301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00780
    Location:1144 → 1408
    CNH; CNH domain
    pfam15796
    Location:426 → 504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:923 → 982
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  15. XM_036164187.1 → XP_036020080.1  serine/threonine-protein kinase MRCK alpha isoform X7

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:373 → 872
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1019 → 1153
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:6 → 336
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00780
    Location:1179 → 1443
    CNH; CNH domain
    pfam15796
    Location:461 → 539
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:958 → 1017
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  16. XM_036164195.1 → XP_036020088.1  serine/threonine-protein kinase MRCK alpha isoform X10

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:338 → 837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:984 → 1118
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1 → 301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00780
    Location:1144 → 1408
    CNH; CNH domain
    pfam15796
    Location:426 → 504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:923 → 982
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  17. XM_036164200.1 → XP_036020093.1  serine/threonine-protein kinase MRCK alpha isoform X13

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    pfam08826
    Location:731 → 791
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:373 → 792
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:938 → 1072
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:6 → 336
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00780
    Location:1098 → 1362
    CNH; CNH domain
    cd20864
    Location:877 → 936
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  18. XM_011238802.3 → XP_011237104.1  serine/threonine-protein kinase MRCK alpha isoform X7

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:373 → 872
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1019 → 1153
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:6 → 336
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00780
    Location:1179 → 1443
    CNH; CNH domain
    pfam15796
    Location:461 → 539
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:958 → 1017
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

RNA

  1. XR_001784122.3 RNA Sequence

  2. XR_001784125.3 RNA Sequence

  3. XR_001784127.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UU96.2 GenPept UniProtKB/Swiss-Prot:Q3UU96

Gene LinkOut

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