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IP3K2 Inositol 1,4,5-triphosphate kinase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32285, updated on 4-Jan-2025

Summary

Official Symbol
IP3K2provided by FlyBase
Official Full Name
Inositol 1,4,5-triphosphate kinase 2provided by FlyBase
Primary source
FLYBASE:FBgn0283680
Locus tag
Dmel_CG45017
See related
AllianceGenome:FB:FBgn0283680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12724; CG15745; CG1630; CG34359; CG4501; CG45017; D-IP3K2; DIP3K2; Dmel\CG45017; dmIP3K2; dmIP3Kbeta; dmIP[[3]]beta; ip3k2; IP[[3]]K-2; IP[[3]]K2; NP2758; wy
Old locus tag
CG12724; CG1630; Dmel_CG12724; Dmel_CG15745; Dmel_CG1630; Dmel_CG34359
Summary
Enables calcium-dependent protein binding activity; calmodulin binding activity; and inositol-1,4,5-trisphosphate 3-kinase activity. Involved in autophagic cell death; inositol phosphate biosynthetic process; and negative regulation of cytosolic calcium ion concentration. Located in cytoplasm. Is expressed in several structures, including Kenyon cell; dopaminergic PPL1 neuron; embryonic/larval midgut primordium; epidermis; and gut section. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to several human genes including ITPKB (inositol-trisphosphate 3-kinase B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See IP3K2 in Genome Data Viewer
Location:
11E9-11E11; 1-42 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13303633..13329303)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13197666..13223336)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Remoulade Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45018 Neighboring gene long non-coding RNA:CR32636 Neighboring gene Peroxiredoxin 2

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
is_active_in nucleus  

General protein information

Preferred Names
inositol 1,4,5-triphosphate kinase 2
Names
CG45017-PA
CG45017-PB
CG45017-PC
CG45017-PD
CG45017-PG
CG45017-PH
IP3K2-PA
IP3K2-PB
IP3K2-PC
IP3K2-PD
IP3K2-PG
IP3K2-PH
wavy
NP_001096969.1
NP_001285200.1
NP_001285201.1
NP_572873.2
NP_572875.1
NP_727688.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13303633..13329303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298272.1 → NP_001285201.1  inositol 1,4,5-triphosphate kinase 2, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285201.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYE7
    Conserved Domains (1) summary
    pfam03770
    Location:217 → 426
    IPK; Inositol polyphosphate kinase
  2. NM_132645.3 → NP_572873.2  inositol 1,4,5-triphosphate kinase 2, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572873.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KV26
    Conserved Domains (1) summary
    pfam03770
    Location:441 → 650
    IPK; Inositol polyphosphate kinase
  3. NM_001103499.2 → NP_001096969.1  inositol 1,4,5-triphosphate kinase 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096969.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYE7
    Conserved Domains (1) summary
    pfam03770
    Location:217 → 426
    IPK; Inositol polyphosphate kinase
  4. NM_001298271.1 → NP_001285200.1  inositol 1,4,5-triphosphate kinase 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285200.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYE7
    Conserved Domains (1) summary
    pfam03770
    Location:217 → 426
    IPK; Inositol polyphosphate kinase
  5. NM_167358.2 → NP_727688.1  inositol 1,4,5-triphosphate kinase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727688.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXS8, Q9VYE6
    Related
    FBpp0310585
    Conserved Domains (1) summary
    pfam03770
    Location:419 → 628
    IPK; Inositol polyphosphate kinase
  6. NM_132647.2 → NP_572875.1  inositol 1,4,5-triphosphate kinase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572875.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXS8, Q9VYE6
    Related
    FBpp0310584
    Conserved Domains (1) summary
    pfam03770
    Location:419 → 628
    IPK; Inositol polyphosphate kinase
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