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MAN1 MAN1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37838, updated on 4-Jan-2025

Summary

Official Symbol
MAN1provided by FlyBase
Official Full Name
MAN1provided by FlyBase
Primary source
FLYBASE:FBgn0034962
Locus tag
Dmel_CG3167
See related
AllianceGenome:FB:FBgn0034962
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD24895; CG3167; dMan1; dMAN1; Dmel\CG3167
Summary
Predicted to enable chromatin DNA binding activity. Involved in negative regulation of BMP signaling pathway. Located in endomembrane system. Is expressed in adult head; organism; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome and cataract 46 juvenile-onset. Orthologous to several human genes including LEMD3 (LEM domain containing 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See MAN1 in Genome Data Viewer
Location:
60B5-60B5; 2-106 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24033974..24036707)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19921497..19924230)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chip Neighboring gene CCR4-NOT transcription complex subunit 11 Neighboring gene Integrator 1 Neighboring gene twinstar

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin DNA binding  
enables nucleic acid binding  
Component Evidence Code Pubs
located_in endomembrane system PubMed 

General protein information

Preferred Names
MAN1
Names
CG3167-PA
CG3167-PB
CG3167-PC
MAN1-PA
MAN1-PB
MAN1-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24033974..24036707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299883.1NP_001286812.1  MAN1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286812.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JRE4, Q961B2
    Conserved Domains (3) summary
    smart00540
    Location:447
    LEM; in nuclear membrane-associated proteins
    cd12286
    Location:542631
    RRM_Man1; RNA recognition motif in inner nuclear membrane protein Man1 (Man1) and similar proteins
    pfam09402
    Location:381509
    MSC; Man1-Src1p-C-terminal domain
  2. NM_166651.2NP_726404.1  MAN1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726404.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JRE4, Q961B2
    Related
    FBpp0072075
    Conserved Domains (3) summary
    smart00540
    Location:447
    LEM; in nuclear membrane-associated proteins
    cd12286
    Location:542631
    RRM_Man1; RNA recognition motif in inner nuclear membrane protein Man1 (Man1) and similar proteins
    pfam09402
    Location:381509
    MSC; Man1-Src1p-C-terminal domain
  3. NM_138029.3NP_611873.1  MAN1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611873.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JRE4, Q961B2
    Related
    FBpp0072076
    Conserved Domains (3) summary
    smart00540
    Location:447
    LEM; in nuclear membrane-associated proteins
    cd12286
    Location:542631
    RRM_Man1; RNA recognition motif in inner nuclear membrane protein Man1 (Man1) and similar proteins
    pfam09402
    Location:381509
    MSC; Man1-Src1p-C-terminal domain
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