U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Dg Dystroglycan [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36773, updated on 4-Jan-2025

    Summary

    Official Symbol
    Dgprovided by FlyBase
    Official Full Name
    Dystroglycanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034072
    Locus tag
    Dmel_CG18250
    See related
    AllianceGenome:FB:FBgn0034072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha-DG; atu; CG18250; CT41273; dg; DG; dgn; DmDG; Dmel\CG18250; dys
    Summary
    Enables laminin receptor activity. Involved in several processes, including imaginal disc-derived wing vein specification; nervous system development; and oogenesis. Located in several cellular components, including T-tubule; Z disc; and basal plasma membrane. Part of dystroglycan complex. Is expressed in several structures, including ectodermal derivative; epithelium; germline cell; gut section; and muscle cell. Used to study lissencephaly; muscular dystrophy; and muscular dystrophy-dystroglycanopathy. Human ortholog(s) of this gene implicated in bronchopulmonary dysplasia; inclusion body myositis; and muscular dystrophy (multiple). Orthologous to human DAG1 (dystroglycan 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    52E2-52E4; 2-77 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16081176..16098564, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11968681..11986069, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mir-137 stem loop Neighboring gene long non-coding RNA:CR43415 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene uncharacterized protein Neighboring gene Rho1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables laminin binding  
    enables laminin receptor activity PubMed 
    enables protein binding PubMed 
    enables structural constituent of muscle PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization PubMed 
    involved_in axon guidance  
    involved_in axon guidance PubMed 
    involved_in brain morphogenesis PubMed 
    involved_in establishment of cell polarity PubMed 
    involved_in establishment or maintenance of apical/basal cell polarity PubMed 
    involved_in establishment or maintenance of cell polarity PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity PubMed 
    involved_in establishment or maintenance of polarity of follicular epithelium PubMed 
    involved_in germarium-derived egg chamber formation PubMed 
    involved_in growth of a germarium-derived egg chamber PubMed 
    involved_in imaginal disc-derived wing vein specification PubMed 
    involved_in morphogenesis of an epithelium  
    involved_in muscle attachment PubMed 
    involved_in muscle cell cellular homeostasis PubMed 
    involved_in nerve development  
    involved_in oocyte anterior/posterior axis specification PubMed 
    involved_in oocyte axis specification PubMed 
    involved_in regulation of glycolytic process PubMed 
    involved_in regulation of synaptic activity PubMed 
    involved_in sarcomere organization PubMed 
    Component Evidence Code Pubs
    located_in T-tubule PubMed 
    located_in Z disc PubMed 
    located_in basal plasma membrane PubMed 
    part_of dystroglycan complex  
    part_of dystroglycan complex PubMed 
    part_of dystroglycan complex PubMed 
    part_of dystrophin-associated glycoprotein complex  
    part_of dystrophin-associated glycoprotein complex PubMed 
    located_in membrane  
    located_in neuromuscular junction PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane PubMed 
    is_active_in sarcolemma  
    located_in sarcolemma PubMed 

    General protein information

    Preferred Names
    dystroglycan
    Names
    CG18250-PA
    CG18250-PB
    CG18250-PC
    CG18250-PD
    Dg-PA
    Dg-PB
    Dg-PC
    Dg-PD
    alphaDystroglycan
    atsugari
    dystroglican
    dystroglycan-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16081176..16098564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176183.3 → NP_788363.1  dystroglycan, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788363.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHF6
      Conserved Domains (3) summary
      cd11303
      Location:885 → 986
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      cd11305
      Location:60 → 190
      alpha_DG_C; C-terminal domain of alpha dystroglycan
      pfam05454
      Location:989 → 1262
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    2. NM_166138.5 → NP_725523.3  dystroglycan, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725523.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA89, Q8WR09
      Related
      FBpp0086395
      Conserved Domains (3) summary
      cd11303
      Location:537 → 638
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      cd11305
      Location:60 → 190
      alpha_DG_C; C-terminal domain of alpha dystroglycan
      pfam05454
      Location:641 → 914
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    3. NM_079032.4 → NP_523756.1  dystroglycan, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523756.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8STB9, Q8WR09, Q9V7I7
      Related
      FBpp0086394
      Conserved Domains (3) summary
      cd11303
      Location:620 → 721
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      cd11305
      Location:60 → 190
      alpha_DG_C; C-terminal domain of alpha dystroglycan
      pfam05454
      Location:724 → 997
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    4. NM_176184.4 → NP_788364.2  dystroglycan, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788364.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WR08
      Related
      FBpp0086396
      Conserved Domains (3) summary
      cd11303
      Location:802 → 903
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      cd11305
      Location:60 → 190
      alpha_DG_C; C-terminal domain of alpha dystroglycan
      pfam05454
      Location:906 → 1179
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    External link. Please review our privacy policy.