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Coq6 Coenzyme Q6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33777, updated on 4-Jan-2025

Summary

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Official Symbol
Coq6provided by FlyBase
Official Full Name
Coenzyme Q6provided by FlyBase
Primary source
FLYBASE:FBgn0031713
Locus tag
Dmel_CG7277
See related
AllianceGenome:FB:FBgn0031713
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7277; Dmel\CG7277
Summary
Predicted to enable 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity. Predicted to be involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be part of ubiquinone biosynthesis complex. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; gut section; and larval muscle system. Used to study nephrotic syndrome and primary coenzyme Q10 deficiency 6. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 6. Orthologous to human COQ6 (coenzyme Q6, monooxygenase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Coq6 in Genome Data Viewer
Location:
25E5-25E5; 2-17 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5530620..5532223, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5530620..5532223, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44793 Neighboring gene Elongator complex protein 4 Neighboring gene Chromosome associated protein D3 Neighboring gene Cytochrome c oxidase copper chaperone COX11 Neighboring gene uncharacterized protein Neighboring gene tombola Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Personalized Model of COQ2 Nephropathy Rescued by the Wild-Type COQ2 Allele or Dietary Coenzyme Q(10) Supplementation. Zhu JY, et al. J Am Soc Nephrol, 2017 Sep. PMID 28428331, Free PMC Article
  2. Gene Expression as a Dosimeter in Irradiated Drosophila melanogaster. Shrestha S, et al. J Comput Biol, 2017 Dec. PMID 29035581, Free PMC Article
  3. Invertebrate models for coenzyme q10 deficiency. Fernández-Ayala DJ, et al. Mol Syndromol, 2014 Jul. PMID 25126050, Free PMC Article
  4. Tombola, a tesmin/TSO1-family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with always early. Jiang J, et al. Development, 2007 Apr. PMID 17360778, Free PMC Article
  5. In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway. Lindström R, et al. BMC Genet, 2017 Jun 2. PMID 28578657, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquinone biosynthesis complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
coenzyme Q6
Names
CG7277-PA
Coq6-PA
NP_608934.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5530620..5532223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135090.4 → NP_608934.1  coenzyme Q6 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608934.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VMQ5
    Related
    FBpp0078759
    Conserved Domains (2) summary
    TIGR01988
    Location:58 → 476
    Ubi-OHases; Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family
    TIGR01989
    Location:58 → 471
    COQ6; ubiquinone biosynthesis monooxygenase COQ6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMQ5.1 Q9VMQ5

Gene LinkOut

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