Rack1 Receptor of activated protein kinase C 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rack1provided by FlyBase
Official Full Name: Receptor of activated protein kinase C 1provided by FlyBase
Primary source: FLYBASE:FBgn0020618
Locus tag: Dmel_CG7111
See related: AllianceGenome:FB:FBgn0020618
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7111; Dmel\CG7111; dRack1; i173; rack1; RACK1
Summary: Enables protein-macromolecule adaptor activity. A structural constituent of ribosome. Involved in several processes, including IRES-dependent viral translational initiation; macroautophagy; and regulation of protein modification process. Located in autophagosome and cytosolic ribosome. Is expressed in adult brain cell body rind; adult head; adult heart; and organism. Orthologous to human RACK1 (receptor for activated C kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 28D1-28D1; 2-29 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (7825347..7827315, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (7825347..7827315, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RACK1 and IRE1 participate in the translational quality control of amyloid precursor protein in Drosophila models of Alzheimer's disease.
Title: RACK1 and IRE1 participate in the translational quality control of amyloid precursor protein in Drosophila models of Alzheimer's disease.
Neuroligin 2 governs synaptic morphology and function through RACK1-cofilin signaling in Drosophila.
Title: Neuroligin 2 governs synaptic morphology and function through RACK1-cofilin signaling in Drosophila.
Dual functions of Rack1 in regulating Hedgehog pathway.
Title: Dual functions of Rack1 in regulating Hedgehog pathway.
RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila.
Title: RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila.
A functional screen did not reveal any protein sharing the interesting properties of RACK1, which is required for IRES-dependent translation and not essential for cell viability. Intriguingly however, 10 of the RACK1 partners identified restrict replication of Cricket paralysis virus (CrPV), an IRES-containing virus.
Title: Definition of a RACK1 Interaction Network in Drosophila melanogaster Using SWATH-MS.
Using the model organism Drosophila melanogaster, studyidentify the ribosomal protein RACK1 as a cellular factor required for infection by internal ribosome entry site (IRES)-containing viruses.
Title: RACK1 controls IRES-mediated translation of viruses.
Data show that the genetic interaction between p38b MAPK and Rack1 controls muscle aggregate formation, locomotor function, and longevity.
Title: In vivo interaction proteomics reveal a novel p38 mitogen-activated protein kinase/Rack1 pathway regulating proteostasis in Drosophila muscle.
The fundamental role of Rack1 in autophagy and glycogen synthesis, is reported.
Title: Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila.
RACK1 is essential at multiple steps of Drosophila development, particularly in oogenesis, where somatic RACK1 is required for proper germ-line function.
Title: Characterization of RACK1 function in Drosophila development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0670 (e-PCR)
- UniSTS:21911

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein kinase C binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in IRES-dependent viral translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic translation	IC Inferred by Curator more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translational frameshifting	IBA Inferred from Biological aspect of Ancestor more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation by host of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein ubiquitination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of autophagosome size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rescue of stalled ribosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation reinitiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: receptor of activated protein kinase C 1

Names: CG7111-PA; CG7111-PB; CG7111-PC; CG7111-PD; Rack1-PA; Rack1-PB; Rack1-PC; Rack1-PD; guanine nucleotide-binding protein beta-subunit like protein; receptor for activated C kinase 1; receptor for activated protein kinase C1; receptor of activated PKC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

7825347..7827315 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273289.1 → NP_001260218.1 receptor of activated protein kinase C 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260218.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18640, Q9VLW5

UniProtKB/TrEMBL

M9PCC1

Conserved Domains (2) summary

cd00200
Location:7 → 312

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:18 → 62

7WD40; WD40 repeat [structural motif]
NM_001298794.1 → NP_001285723.1 receptor of activated protein kinase C 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285723.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18640, Q9VLW5

UniProtKB/TrEMBL

M9PCC1

Conserved Domains (2) summary

cd00200
Location:7 → 312

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:18 → 62

7WD40; WD40 repeat [structural motif]
NM_057921.4 → NP_477269.1 receptor of activated protein kinase C 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477269.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18640, Q9VLW5

UniProtKB/TrEMBL

M9PCC1

Related

FBpp0079187

Conserved Domains (2) summary

cd00200
Location:7 → 312

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:18 → 62

7WD40; WD40 repeat [structural motif]
NM_001273288.1 → NP_001260217.1 receptor of activated protein kinase C 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260217.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PB67

Conserved Domains (3) summary

COG2319
Location:1 → 108

WD40; WD40 repeat [General function prediction only]

sd00039
Location:18 → 61

7WD40; WD40 repeat [structural motif]

cl02567
Location:7 → 107

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...