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ncd non-claret disjunctional [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43517, updated on 4-Jan-2025

Summary

Official Symbol
ncdprovided by FlyBase
Official Full Name
non-claret disjunctionalprovided by FlyBase
Primary source
FLYBASE:FBgn0002924
Locus tag
Dmel_CG7831
See related
AllianceGenome:FB:FBgn0002924
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ca; ca[nd]; cd; CG7831; Dmel\CG7831; DmNcd; DmNCD; KIF C1; KIFC1; l(3)05884; Ncd; NCD; ndc
Summary
Enables protein homodimerization activity. Involved in several processes, including distributive segregation; microtubule cytoskeleton organization; and regulation of cell cycle process. Located in microtubule cytoskeleton and nucleus. Colocalizes with cortical microtubule cytoskeleton and perinuclear region of cytoplasm. Is expressed in several structures, including antennal primordium; central brain primordium; embryonic central brain neurons; ganglia; and head epidermis primordium. Orthologous to human KIFC1 (kinesin family member C1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See ncd in Genome Data Viewer
Location:
99C1-99C2; 3-99 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29804290..29807127, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25630012..25632849, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Death related ICE-like caspase Neighboring gene Electron transfer flavoprotein beta subunit Neighboring gene uncharacterized protein Neighboring gene claret Neighboring gene Vacuolar protein sorting 16B Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding  
enables microtubule binding  
enables microtubule motor activity  
enables minus-end-directed microtubule motor activity PubMed 
enables protein homodimerization activity PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation PubMed 
involved_in distributive segregation PubMed 
involved_in distributive segregation PubMed 
involved_in mRNA transport PubMed 
involved_in mRNA transport PubMed 
involved_in meiotic spindle assembly PubMed 
involved_in meiotic spindle organization PubMed 
involved_in microtubule bundle formation PubMed 
involved_in microtubule-based movement  
involved_in minus-end directed microtubule sliding PubMed 
involved_in mitotic centrosome separation PubMed 
involved_in mitotic centrosome separation PubMed 
involved_in mitotic spindle assembly PubMed 
involved_in mitotic spindle elongation PubMed 
involved_in mitotic spindle organization PubMed 
involved_in regulation of mitotic spindle assembly PubMed 
involved_in regulation of mitotic spindle elongation PubMed 
involved_in spindle assembly involved in female meiosis PubMed 
involved_in spindle organization PubMed 
Component Evidence Code Pubs
located_in centrosome PubMed 
colocalizes_with cortical microtubule cytoskeleton PubMed 
located_in meiotic spindle PubMed 
located_in mitotic spindle microtubule PubMed 
located_in nucleus PubMed 
colocalizes_with perinuclear region of cytoplasm PubMed 
located_in spindle PubMed 

General protein information

Preferred Names
non-claret disjunctional
Names
CG7831-PA
CG7831-PB
Kinesin3A
Non-Claret disjunctional
claret nondisjunctional
kinesin-14
ncd-PA
ncd-PB
non-claret disjunction
non-claret-disjunctional
nonclaret disjunction
nonclaret disjunctional

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29804290..29807127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300663.1 → NP_001287592.1  non-claret disjunctional, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287592.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P20480, Q9VAG8
    UniProtKB/TrEMBL
    A0A0B4LI25, B6UXE6
    Conserved Domains (2) summary
    smart00129
    Location:348 → 678
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01366
    Location:346 → 672
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
  2. NM_057303.5 → NP_476651.1  non-claret disjunctional, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476651.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P20480, Q9VAG8
    UniProtKB/TrEMBL
    A0A0B4LI25, B6UXE6
    Related
    FBpp0084900
    Conserved Domains (2) summary
    smart00129
    Location:348 → 678
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01366
    Location:346 → 672
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
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