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SF1 Splicing factor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43912, updated on 4-Jan-2025

Summary

Official Symbol
SF1provided by FlyBase
Official Full Name
Splicing factor 1provided by FlyBase
Primary source
FLYBASE:FBgn0025571
Locus tag
Dmel_CG5836
See related
AllianceGenome:FB:FBgn0025571
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg5836; CG5836; Dmel\CG5836; dSF1; p70
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of mRNA splicing, via spliceosome. Located in nucleus. Part of precatalytic spliceosome. Orthologous to human SF1 (splicing factor 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See SF1 in Genome Data Viewer
Location:
90B4-90B4; 3-61 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17540421..17545148)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13366143..13370870)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene lethal (3) 07882 Neighboring gene Pyrroline-5-carboxylate reductase-like 2 Neighboring gene Peroxiredoxin 3 Neighboring gene H6-like-homeobox

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding  
enables RNA binding  
enables mRNA binding  
enables zinc ion binding  
Component Evidence Code Pubs
is_active_in nucleus  
located_in nucleus PubMed 
part_of precatalytic spliceosome PubMed 
part_of spliceosomal complex PubMed 

General protein information

Preferred Names
splicing factor 1
Names
CG5836-PA
CG5836-PB
CG5836-PC
SF1-PA
SF1-PB
SF1-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17540421..17545148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079915.3 → NP_524654.2  splicing factor 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524654.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEJ1
    Related
    FBpp0082897
    Conserved Domains (3) summary
    COG5176
    Location:253 → 512
    MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]
    cd02395
    Location:392 → 510
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16275
    Location:274 → 385
    SF1-HH; Splicing factor 1 helix-hairpin domain
  2. NM_001275744.1 → NP_001262673.1  splicing factor 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262673.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGU8
    Conserved Domains (1) summary
    pfam16275
    Location:274 → 308
    SF1-HH; Splicing factor 1 helix-hairpin domain
  3. NM_001275743.2 → NP_001262672.1  splicing factor 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262672.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG60
    Conserved Domains (1) summary
    pfam16275
    Location:274 → 334
    SF1-HH; Splicing factor 1 helix-hairpin domain
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