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elgi early girl [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39735, updated on 9-Dec-2024

Summary

Official Symbol
elgiprovided by FlyBase
Official Full Name
early girlprovided by FlyBase
Primary source
FLYBASE:FBgn0283649
Locus tag
Dmel_CG17033
See related
AllianceGenome:FB:FBgn0283649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17033; Dmel\CG17033; dNrdp1; Elgi; Nrdp1
Summary
Enables myosin binding activity and ubiquitin protein ligase activity. Involved in imaginal disc-derived wing vein morphogenesis and regulation of meiotic cell cycle. Located in cytoplasm. Is expressed in organism. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RNF41 (ring finger protein 41). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See elgi in Genome Data Viewer
Location:
72B2-72C1; 3-43 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15956550..15958433)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15949650..15951533)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Protein kinase, cAMP-dependent, catalytic subunit 3 Neighboring gene GXIVsPLA2 Neighboring gene uncharacterized protein Neighboring gene Brr2 U5 snRNP complex subunit

Genomic regions, transcripts, and products

Bibliography

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables myosin binding PubMed 
enables protein binding PubMed 
enables ubiquitin protein ligase activity PubMed 
enables ubiquitin protein ligase activity  
enables ubiquitin-protein transferase activity  
enables zinc ion binding PubMed 
Component Evidence Code Pubs
located_in cytoplasm PubMed 

General protein information

Preferred Names
early girl
Names
CG17033-PA
CG17033-PB
Nrdp1
elgi-PA
elgi-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15956550..15958433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140559.1 → NP_648816.1  early girl, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648816.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUV7
    Related
    FBpp0075265, FBtr0075510
    Conserved Domains (3) summary
    cd00162
    Location:17 → 55
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam08941
    Location:137 → 315
    USP8_interact; USP8 interacting
    cl19105
    Location:83 → 157
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
  2. NM_001274975.1 → NP_001261904.1  early girl, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261904.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUV7
    Conserved Domains (3) summary
    cd00162
    Location:17 → 55
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam08941
    Location:137 → 315
    USP8_interact; USP8 interacting
    cl19105
    Location:83 → 157
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
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