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pkaap pkaap [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34957, updated on 4-Jan-2025

Summary

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Official Symbol
pkaapprovided by FlyBase
Official Full Name
pkaapprovided by FlyBase
Primary source
FLYBASE:FBgn0040079
Locus tag
Dmel_CG4132
See related
AllianceGenome:FB:FBgn0040079
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS02740.4; CG4132; Dmel\CG4132; DS02740.4
Summary
Predicted to enable protein kinase A binding activity. Involved in antimicrobial peptide secretion and exocytosis. Located in cytosol and endosome. Orthologous to human AKAP10 (A-kinase anchoring protein 10). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See pkaap in Genome Data Viewer
Location:
35F1-35F1; 2-52 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16288290..16291195)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16288290..16291195)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene cropped Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Pkaap regulates Rab4/Rab11-dependent traffic and Rab11 exocytosis of innate immune cargo. Sorvina A, et al. Biol Open, 2016 Jun 15. PMID 27190105, Free PMC Article
  2. The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4. King-Jones K, et al. J Mol Biol, 1999 Aug 6. PMID 10438607
  3. A tissue specific cytochrome P450 required for the structure and function of Drosophila sensory organs. Willingham AT, et al. Mech Dev, 2004 Oct. PMID 15327788
  4. Genome annotation assessment in Drosophila melanogaster. Reese MG, et al. Genome Res, 2000 Apr. PMID 10779488, Free PMC Article
  5. Genie--gene finding in Drosophila melanogaster. Reese MG, et al. Genome Res, 2000 Apr. PMID 10779493, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein kinase A binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antimicrobial peptide secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pkaap
Names
CG4132-PA
pkaap-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16288290..16291195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135939.3 → NP_609783.1  pkaap [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609783.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YU54, Q9V3I3
    Related
    FBpp0080384
    Conserved Domains (3) summary
    cd08721
    Location:324 → 444
    RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
    cd12804
    Location:561 → 605
    AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10
    cl02565
    Location:109 → 308
    RGS; Regulator of G protein signaling (RGS) domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7YU54 Q7YU54
Q9V3I3 Q9V3I3

Gene LinkOut

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