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    RasGAP1 Ras GTPase activating protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39158, updated on 27-Dec-2024

    Summary

    Official Symbol
    RasGAP1provided by FlyBase
    Official Full Name
    Ras GTPase activating protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0004390
    Locus tag
    Dmel_CG6721
    See related
    AllianceGenome:FB:FBgn0004390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6721; Dmel\CG6721; FBpp0076097; gap; Gap; GAP; Gap 1; gap1; Gap1; GAP1; mip; Ras-GAP; rasGAP; RasGAP; RasGap1; rI533; sxt
    Summary
    Involved in several processes, including negative regulation of cell size; negative regulation of signal transduction; and positive regulation of R7 cell differentiation. Located in plasma membrane. Is expressed in several structures, including central nervous system; imaginal disc; longitudinal trunk visceral muscle primordium; somatic trunk mesoderm; and visceral trunk mesoderm. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human RASA2 (RAS p21 protein activator 2) and RASA3 (RAS p21 protein activator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See RasGAP1 in Genome Data Viewer
    Location:
    67C10-67C11; 3-31 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9839093..9855285, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9832193..9848385, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Inhibitor-2 Neighboring gene Cyclin-dependent kinase 8 Neighboring gene uncharacterized protein Neighboring gene calcium-independent phospholipase A2 VIA

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification, embryo PubMed 
    involved_in imaginal disc-derived wing morphogenesis PubMed 
    involved_in intracellular signal transduction  
    involved_in negative regulation of R7 cell differentiation PubMed 
    involved_in negative regulation of cell size PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway PubMed 
    involved_in negative regulation of sevenless signaling pathway PubMed 
    involved_in negative regulation of torso signaling pathway PubMed 
    involved_in negative regulation of torso signaling pathway PubMed 
    involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway PubMed 
    involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway PubMed 
    involved_in positive regulation of R7 cell differentiation PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    Ras GTPase activating protein 1
    Names
    CG6721-PA
    CG6721-PB
    CG6721-PC
    GTPase activating protein 1
    GTPase activating protein1
    GTPase-activating protein 1
    RasGAP1-PA
    RasGAP1-PB
    RasGAP1-PC
    more inner photoreceptors
    seven extra
    sextra

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9839093..9855285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168382.2 → NP_729562.1  Ras GTPase activating protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729562.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1S6, P48423, Q6NP17, Q9VT58
      Related
      FBpp0076097
      Conserved Domains (7) summary
      smart00107
      Location:862 → 897
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:280 → 462
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:44 → 169
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05128
      Location:473 → 740
      RasGAP_GAP1_like; Ras-GTPase Activating Domain of GAP1 and similar proteins
      smart00323
      Location:449 → 797
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd01244
      Location:763 → 867
      PH_GAP1-like; RAS p21 protein activator (GTPase activating protein) family pleckstrin homology (PH) domain
      pfam00169
      Location:761 → 859
      PH; PH domain
    2. NM_079290.3 → NP_524014.2  Ras GTPase activating protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524014.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1S6, P48423, Q6NP17, Q9VT58
      Related
      FBpp0076096
      Conserved Domains (7) summary
      smart00107
      Location:862 → 897
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:280 → 462
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:44 → 169
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05128
      Location:473 → 740
      RasGAP_GAP1_like; Ras-GTPase Activating Domain of GAP1 and similar proteins
      smart00323
      Location:449 → 797
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd01244
      Location:763 → 867
      PH_GAP1-like; RAS p21 protein activator (GTPase activating protein) family pleckstrin homology (PH) domain
      pfam00169
      Location:761 → 859
      PH; PH domain
    3. NM_001274735.1 → NP_001261664.1  Ras GTPase activating protein 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261664.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF62
      Conserved Domains (7) summary
      smart00107
      Location:862 → 897
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:280 → 462
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:44 → 169
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05128
      Location:473 → 740
      RasGAP_GAP1_like; Ras-GTPase Activating Domain of GAP1 and similar proteins
      smart00323
      Location:449 → 797
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd01244
      Location:763 → 867
      PH_GAP1-like; RAS p21 protein activator (GTPase activating protein) family pleckstrin homology (PH) domain
      pfam00169
      Location:761 → 859
      PH; PH domain
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