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RhoGAP18B Rho GTPase activating protein at 18B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32898, updated on 4-Jan-2025

Summary

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Official Symbol
RhoGAP18Bprovided by FlyBase
Official Full Name
Rho GTPase activating protein at 18Bprovided by FlyBase
Primary source
FLYBASE:FBgn0261461
Locus tag
Dmel_CG42274
See related
AllianceGenome:FB:FBgn0261461
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
5-131; CG17015; CG42274; CG7481; CG7502; CG7531; Dmel\CG42274; whir
Old locus tag
Dmel_CG7481; Dmel_CG7502
Summary
Enables GTPase activator activity and small GTPase binding activity. Involved in actin cytoskeleton organization. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including adult central complex; adult gnathal ganglion; adult mushroom body; head epidermis primordium; and organism subdivision. Used to study alcohol use disorder. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See RhoGAP18B in Genome Data Viewer
Location:
18A3-18A4; 1-62 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19136107..19167082, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19030140..19061115, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45711 Neighboring gene Odorant-binding protein 18a Neighboring gene mir-4959 stem loop Neighboring gene Innexin 5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Emerging roles of actin cytoskeleton regulating enzymes in drug addiction: actin or reactin'? Rothenfluh A, et al. Curr Opin Neurobiol, 2013 Aug. PMID 23428655, Free PMC Article
  2. Oviposition preference for and positional avoidance of acetic acid provide a model for competing behavioral drives in Drosophila. Joseph RM, et al. Proc Natl Acad Sci U S A, 2009 Jul 7. PMID 19541615, Free PMC Article
  3. Drosophila RhoGAP18B regulates actin cytoskeleton during border cell migration. Lei F, et al. PLoS One, 2023. PMID 36662713, Free PMC Article
  4. The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans. Gonzalez DA, et al. Mol Psychiatry, 2018 Mar. PMID 28607459, Free PMC Article
  5. Preferential ethanol consumption in Drosophila models features of addiction. Devineni AV, et al. Curr Biol, 2009 Dec 29. PMID 20005106, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila RhoGAP18B regulates actin cytoskeleton during border cell migration.
    Title: Drosophila RhoGAP18B regulates actin cytoskeleton during border cell migration.
  2. Results suggest that the RhoGAP18B-PA isoform mainly inactivates Cdc42, while PC and PD suppress Rac1 and Rho1 to activate cofilin.
    Title: RhoGAP18B Isoforms Act on Distinct Rho-Family GTPases and Regulate Behavioral Responses to Alcohol via Cofilin.
  3. Data show that distinct RhoGAPs, encoded by the same gene, regulate different manifestations of acute ethanol intoxication.
    Title: Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rho GTPase activating protein at 18B
Names
CG42274-PB
CG42274-PC
CG42274-PD
CG42274-PF
CG42274-PH
RhoGAP18B-PB
RhoGAP18B-PC
RhoGAP18B-PD
RhoGAP18B-PF
RhoGAP18B-PH
white rabbit
whiterabbit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19136107..19167082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_133124.4 → NP_573352.2  Rho GTPase activating protein at 18B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573352.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q00IM9, Q9VWL7
    Conserved Domains (1) summary
    pfam00620
    Location:1141 → 1289
    RhoGAP; RhoGAP domain

  2. NM_001144748.2 → NP_001138220.1  Rho GTPase activating protein at 18B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138220.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q00IN0
    Conserved Domains (1) summary
    pfam00620
    Location:576 → 724
    RhoGAP; RhoGAP domain

  3. NM_001298497.1 → NP_001285426.1  Rho GTPase activating protein at 18B, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285426.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RJ6, Q9VWL9
    Conserved Domains (1) summary
    pfam00620
    Location:292 → 440
    RhoGAP; RhoGAP domain

  4. NM_001144749.2 → NP_001138221.1  Rho GTPase activating protein at 18B, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138221.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RJ6, Q9VWL9
    Conserved Domains (1) summary
    pfam00620
    Location:292 → 440
    RhoGAP; RhoGAP domain

  5. NM_133123.2 → NP_573351.1  Rho GTPase activating protein at 18B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573351.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RJ6, Q9VWL9
    Related
    FBpp0288897
    Conserved Domains (1) summary
    pfam00620
    Location:292 → 440
    RhoGAP; RhoGAP domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00IM9 Q00IM9
Q00IN0 Q00IN0
Q9VWL7 Q9VWL7
Q9VWL9 Q9VWL9

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