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Conserved domains on  [gi|221499246|ref|NP_001138220|]
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Rho GTPase activating protein at 18B, isoform D [Drosophila melanogaster]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10457345)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
576-720 2.68e-45

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


:

Pssm-ID: 459875  Cd Length: 148  Bit Score: 158.86  E-value: 2.68e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246  576 PRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDP-RWLKTDDIHTLTSLHKQFFRELTSPLITQEAYER 654
Cdd:pfam00620   1 PLIVRKCVEYLEK-RGLDTEGIFRVSGSASRIKELREAFDRGPDVdLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221499246  655 LGRSL---NDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQ 720
Cdd:pfam00620  80 FIEAAklpDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
 
Name Accession Description Interval E-value
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
576-720 2.68e-45

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 158.86  E-value: 2.68e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246  576 PRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDP-RWLKTDDIHTLTSLHKQFFRELTSPLITQEAYER 654
Cdd:pfam00620   1 PLIVRKCVEYLEK-RGLDTEGIFRVSGSASRIKELREAFDRGPDVdLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221499246  655 LGRSL---NDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQ 720
Cdd:pfam00620  80 FIEAAklpDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
576-738 7.75e-43

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 152.84  E-value: 7.75e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 576 PRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYERL 655
Cdd:cd00159    1 PLIIEKCIEYLEK-NGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 656 ---GRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLL----SANQIQLDIGRM 728
Cdd:cd00159   80 ielAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLrppdSDDELLEDIKKL 159
                        170
                 ....*....|
gi 221499246 729 NMLAKVLIEN 738
Cdd:cd00159  160 NEIVEFLIEN 169
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
573-739 2.10e-38

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 140.48  E-value: 2.10e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246   573 PNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTH--VYDPRWLKTDdIHTLTSLHKQFFRELTSPLITQE 650
Cdd:smart00324   1 KPIPIIVEKCIEYLEK-RGLDTEGIYRVSGSKSRVKELRDAFDSgpDPDLDLSEYD-VHDVAGLLKLFLRELPEPLITYE 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246   651 AYERL---GRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQL---- 723
Cdd:smart00324  79 LYEEFieaAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVaslk 158
                          170
                   ....*....|....*.
gi 221499246   724 DIGRMNMLAKVLIENY 739
Cdd:smart00324 159 DIRHQNTVIEFLIENA 174
 
Name Accession Description Interval E-value
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
576-720 2.68e-45

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 158.86  E-value: 2.68e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246  576 PRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDP-RWLKTDDIHTLTSLHKQFFRELTSPLITQEAYER 654
Cdd:pfam00620   1 PLIVRKCVEYLEK-RGLDTEGIFRVSGSASRIKELREAFDRGPDVdLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221499246  655 LGRSL---NDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQ 720
Cdd:pfam00620  80 FIEAAklpDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
576-738 7.75e-43

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 152.84  E-value: 7.75e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 576 PRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYERL 655
Cdd:cd00159    1 PLIIEKCIEYLEK-NGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 656 ---GRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLL----SANQIQLDIGRM 728
Cdd:cd00159   80 ielAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLrppdSDDELLEDIKKL 159
                        170
                 ....*....|
gi 221499246 729 NMLAKVLIEN 738
Cdd:cd00159  160 NEIVEFLIEN 169
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
573-739 2.10e-38

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 140.48  E-value: 2.10e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246   573 PNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTH--VYDPRWLKTDdIHTLTSLHKQFFRELTSPLITQE 650
Cdd:smart00324   1 KPIPIIVEKCIEYLEK-RGLDTEGIYRVSGSKSRVKELRDAFDSgpDPDLDLSEYD-VHDVAGLLKLFLRELPEPLITYE 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246   651 AYERL---GRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQL---- 723
Cdd:smart00324  79 LYEEFieaAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVaslk 158
                          170
                   ....*....|....*.
gi 221499246   724 DIGRMNMLAKVLIENY 739
Cdd:smart00324 159 DIRHQNTVIEFLIENA 174
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
558-743 3.94e-33

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 126.36  E-value: 3.94e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 558 FAAPLSALELNmtDHPNVPRfVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRK-------KLTHVYDPRWLktDDIHT 630
Cdd:cd04398    1 FGVPLEDLILR--EGDNVPN-IVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKElfdkdplNVLLISPEDYE--SDIHS 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 631 LTSLHKQFFRELTSPLITQEAYERLGRSLN-DDAAIERMSL--AFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNL 707
Cdd:cd04398   76 VASLLKLFFRELPEPLLTKALSREFIEAAKiEDESRRRDALhgLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNL 155
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 221499246 708 AIVWGPCLLSANQIQL-DIGRMNMLAKVLIENYDRIF 743
Cdd:cd04398  156 AIIWGPTLMNAAPDNAaDMSFQSRVIETLLDNAYQIF 192
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
571-720 2.14e-28

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 112.48  E-value: 2.14e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 571 DHPNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTH-----VYDPRWlktDDIHTLTSLHKQFFRELTSP 645
Cdd:cd04403   12 ENSTVPKFVRLCIEAVEK-RGLDVDGIYRVSGNLAVIQKLRFAVDHdekldLDDSKW---EDIHVITGALKLFFRELPEP 87
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221499246 646 LITQEAYERLGRSLNDDAAIERMSlAFDD----MPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQ 720
Cdd:cd04403   88 LFPYSLFNDFVAAIKLSDYEQRVS-AVKDliksLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPTLLRPEQ 165
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
573-734 5.46e-26

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 105.84  E-value: 5.46e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 573 PNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQFFRELTSPLIT---Q 649
Cdd:cd04382   15 PMIPALIVHCVNEIEA-RGLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVICGCLKDFLRSLKEPLITfalW 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 650 EAYERLGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASAsNRMPSTNLAIVWGPCLLSANQIQLDigRMN 729
Cdd:cd04382   94 KEFMEAAEILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQSPE-CKMDINNLARVFGPTIVGYSVPNPD--PMT 170

                 ....*
gi 221499246 730 MLAKV 734
Cdd:cd04382  171 ILQDT 175
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
556-722 5.81e-26

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 105.66  E-value: 5.81e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 556 PLFAAPLSalELNMTDHPNVPRFVVDVCAYIEQPECIeqDGLYRASGNKVLVDELRKKLTHVYDP---RWLKTDDIHTLT 632
Cdd:cd04384    1 RVFGCDLT--EHLLNSGQDVPQVLKSCTEFIEKHGIV--DGIYRLSGIASNIQRLRHEFDSEQIPdltKDVYIQDIHSVS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 633 SLHKQFFRELTSPLITQEAYERLGRSLNDDAAIERMSLAFD---DMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAI 709
Cdd:cd04384   77 SLCKLYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDviqQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAI 156
                        170
                 ....*....|...
gi 221499246 710 VWGPCLLSANQIQ 722
Cdd:cd04384  157 VWAPNLLRSKQIE 169
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
558-737 1.68e-25

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 104.06  E-value: 1.68e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 558 FAAPLSALelnMTDHPNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHvyDPRWLKTDD--IHTLTSLH 635
Cdd:cd04377    1 FGVSLSSL---TSEDRSVPLVLEKLLEHIEM-HGLYTEGIYRKSGSANKIKELRQGLDT--DPDSVNLEDypIHVITSVL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 636 KQFFRELTSPLITQEAYERLGRSLNDDAAIER---MSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWG 712
Cdd:cd04377   75 KQWLRELPEPLMTFELYENFLRAMELEEKQERvraLYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFA 154
                        170       180       190
                 ....*....|....*....|....*....|.
gi 221499246 713 PCLLSAN-----QIQL-DIGRMNMLAKVLIE 737
Cdd:cd04377  155 PCILRCPdtadpLQSLqDVSKTTTCVETLIK 185
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
573-743 2.23e-24

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 101.32  E-value: 2.23e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 573 PNVPRFVvDVCAYIEQPECIEQDGLYRASGNKV----LVDELRKKLTHV--YDPRWlktDDIHTLTSLHKQFFRELTSPL 646
Cdd:cd04395   16 PYVPLIV-EVCCNIVEARGLETVGIYRVPGNNAaisaLQEELNRGGFDIdlQDPRW---RDVNVVSSLLKSFFRKLPEPL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 647 ITQEAYERLGRSLNDDAAIERMSL---AFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQL 723
Cdd:cd04395   92 FTNELYPDFIEANRIEDPVERLKElrrLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFGPTLVRTSDDNM 171
                        170       180
                 ....*....|....*....|....*
gi 221499246 724 DIGRMNM-----LAKVLIENYDRIF 743
Cdd:cd04395  172 ETMVTHMpdqckIVETLIQHYDWFF 196
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
557-719 4.85e-24

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 100.62  E-value: 4.85e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 557 LFAAPLSALEL-NMTDHPNVPRFVVDVCAYIEQPecIEQDGLYRASGNKVLVDELRKKLTHVYDPrwLKTDDIHTLTSLH 635
Cdd:cd04394    1 VFGVPLHSLPHsTVPEYGNVPKFLVDACTFLLDH--LSTEGLFRKSGSVVRQKELKAKLEGGEAC--LSSALPCDVAGLL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 636 KQFFRELTSPLIT---QEAYERLGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWG 712
Cdd:cd04394   77 KQFFRELPEPLLPydlHEALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFA 156

                 ....*..
gi 221499246 713 PCLLSAN 719
Cdd:cd04394  157 PNLFQSE 163
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
558-743 6.75e-24

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 99.72  E-value: 6.75e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 558 FAAPLSALELNMTDHPNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQ 637
Cdd:cd04404    6 FGVSLQFLKEKNPEQEPIPPVVRETVEYLQA-HALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 638 FFRELTSPLITQEAYERLGR--SLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCL 715
Cdd:cd04404   85 FLRELPEPLLTFDLYDDIVGflNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPNL 164
                        170       180       190
                 ....*....|....*....|....*....|.
gi 221499246 716 LSAN--QIQLD-IGRMNMLAKVLIENYDRIF 743
Cdd:cd04404  165 LWAKdaSMSLSaINPINTFTKFLLDHQDEIF 195
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
556-715 2.73e-23

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 97.92  E-value: 2.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 556 PLFAAPLSALELNMTDHPNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLH 635
Cdd:cd04393    1 KVFGVPLQELQQAGQPENGVPAVVRHIVEYLEQ-HGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 636 KQFFRELTSPLITQEAYERLGR----SLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVW 711
Cdd:cd04393   80 RLFLQELPEGLIPASLQIRLMQlyqdYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAVF 159

                 ....
gi 221499246 712 GPCL 715
Cdd:cd04393  160 GPDV 163
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
574-739 4.40e-21

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 91.22  E-value: 4.40e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 574 NVPrFVVDVC-AYIEQpECIEQDGLYRASGNKVLVDELRKKLTHvyDPRWLK----TDDIHTLTSLHKQFFRELTSPLIT 648
Cdd:cd04385   14 DIP-VIVDKCiDFITQ-HGLMSEGIYRKNGKNSSVKKLLEAFRK--DARSVQlregEYTVHDVADVLKRFLRDLPDPLLT 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 649 QEAYERLGRSL---NDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQldI 725
Cdd:cd04385   90 SELHAEWIEAAeleNKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQTDEHS--V 167
                        170
                 ....*....|....*..
gi 221499246 726 GRMNMLAKV---LIENY 739
Cdd:cd04385  168 GQTSHEVKViedLIDNY 184
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
572-743 6.25e-21

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 91.42  E-value: 6.25e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 572 HPNVPRFVVDVCayIEQPEC--IEQDGLYRASGNKVLVDELrkKLThvYDPRWLKTD-------DIHTLTSLHKQFFREL 642
Cdd:cd04372   12 HNTQRPMVVDMC--IREIEArgLQSEGLYRVSGFAEEIEDV--KMA--FDRDGEKADisatvypDINVITGALKLYFRDL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 643 TSPLITQEAYERL---GRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSAN 719
Cdd:cd04372   86 PIPVITYDTYPKFidaAKISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTLMRPP 165
                        170       180
                 ....*....|....*....|....*....
gi 221499246 720 QIQL-----DIGRMNMLAKVLIENYDRIF 743
Cdd:cd04372  166 EDSAlttlnDMRYQILIVQLLITNEDVLF 194
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
558-716 1.40e-19

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 87.48  E-value: 1.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 558 FAAPLSALELNMTDHpnVPrFVVDVC-AYIEQPECIEQdGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHK 636
Cdd:cd04378    1 FGVDFSQVPRDFPDE--VP-FIIKKCtSEIENRALGVQ-GIYRVSGSKARVEKLCQAFENGKDLVELSELSPHDISSVLK 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 637 QFFRELTSPLITQEAYER---LGRSLNDDA--------------AIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASAS 699
Cdd:cd04378   77 LFLRQLPEPLILFRLYNDfiaLAKEIQRDTeedkapntpievnrIIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEE 156
                        170
                 ....*....|....*..
gi 221499246 700 NRMPSTNLAIVWGPCLL 716
Cdd:cd04378  157 NKMSPNNLGIVFGPTLI 173
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
595-716 5.03e-19

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 85.43  E-value: 5.03e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 595 DGLYRASGNKVLVDELRKKLTHvyDPRWLKTDD--IHTLTSLHKQFFRELTSPLITQEAYERLGRSLNDDAAIERMSLAF 672
Cdd:cd04407   34 EGIYRKSGSANRMKELHQLLQA--DPENVKLENypIHAITGLLKQWLRELPEPLMTFAQYNDFLRAVELPEKQEQLQAIY 111
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 221499246 673 ---DDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLL 716
Cdd:cd04407  112 rvlEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPCLL 158
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
578-743 1.01e-18

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 85.20  E-value: 1.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 578 FVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKL--THVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYERL 655
Cdd:cd04386   22 LPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALdaGTFSLPLDEFYSDPHAVASALKSYLRELPDPLLTYNLYEDW 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 656 GRSLNDDAAIERMSL---AFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSA-NQIQLDIGRMNML 731
Cdd:cd04386  102 VQAANKPDEDERLQAiwrILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIVLAPNLLWAkNEGSLAEMAAGTS 181
                        170
                 ....*....|....*...
gi 221499246 732 AKV------LIENYDRIF 743
Cdd:cd04386  182 VHVvaivelIISHADWFF 199
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
575-738 2.74e-18

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 83.71  E-value: 2.74e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 575 VPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYER 654
Cdd:cd04408   16 VPFVVVRCTAEIEN-RALGVQGIYRISGSKARVEKLCQAFENGRDLVDLSGHSPHDITSVLKHFLKELPEPVLPFQLYDD 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 655 ---LGRSLNDDA------------AIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLL--- 716
Cdd:cd04408   95 fiaLAKELQRDSekaaespsivenIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPTLLrpl 174
                        170       180
                 ....*....|....*....|....*.
gi 221499246 717 SANQIQ----LDIGRMNMLAKVLIEN 738
Cdd:cd04408  175 VGGDVSmiclLDTGYQAQLVEFLISN 200
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
573-743 9.97e-18

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 82.49  E-value: 9.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 573 PNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAY 652
Cdd:cd04376    7 RQVPRLVESCCQHLEK-HGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 653 ER--LGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASAS-----------NRMPSTNLAIVWGPCLL--- 716
Cdd:cd04376   86 TAfiGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADsidedgqevsgNKMTSLNLATIFGPNLLhkq 165
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 221499246 717 ---------SANQIQLDIGRMNMLAKvLIENYDRIF 743
Cdd:cd04376  166 ksgerefvqASLRIEESTAIINVVQT-MIDNYEELF 200
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
557-743 3.19e-17

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 80.48  E-value: 3.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 557 LFAAPLS-ALELNmtDHPNVPRFVVDVC----AYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTD---DI 628
Cdd:cd04400    1 IFGSPLEeAVELS--SHKYNGRDLPSVVyrciEYLDKNRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSlypDV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 629 HTLTSLHKQFFRELTSPLITQEAYERLGRSLNDDAAIERMSLAFDD----MPEPNRSTLRFLIRHLTRVAAASASNRMPS 704
Cdd:cd04400   79 HTVAGLLKLYLRELPTLILGGELHNDFKRLVEENHDRSQRALELKDlvsqLPQANYDLLYVLFSFLRKIIEHSDVNKMNL 158
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 221499246 705 TNLAIVWGPCLlsanQIQLDIgrmNMLakvLIENYDRIF 743
Cdd:cd04400  159 RNVCIVFSPTL----NIPAGI---FVL---FLTDFDCIF 187
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
557-743 3.76e-17

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 80.42  E-value: 3.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 557 LFAAPLSALelnMTDHpNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKL---THVYdprwLKTDDIHTLTS 633
Cdd:cd04402    1 LFGQPLSNI---CEDD-NLPKPILDMLSLLYQ-KGPSTEGIFRRSANAKACKELKEKLnsgVEVD----LKAEPVLLLAS 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 634 LHKQFFRELTSPLITQEAYERLGRSLNDDAAIERMS----LAfDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAI 709
Cdd:cd04402   72 VLKDFLRNIPGSLLSSDLYEEWMSALDQENEEEKIAelqrLL-DKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAV 150
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 221499246 710 VWGPCLLSANQIQLDIGRMN----MLAKVLIENYDRIF 743
Cdd:cd04402  151 CIAPSLLWPPASSELQNEDLkkvtSLVQFLIENCQEIF 188
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
592-738 2.63e-16

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 78.20  E-value: 2.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 592 IEQDGLYRASGNKVLVDELrkkLTHVYDPRW-------LKTD--DIHTLTSLHKQFFRELTSPLITQEAYERL---GRSL 659
Cdd:cd04374   44 INEQGLYRVVGVNSKVQKL---LSLGLDPKTstpgdvdLDNSewEIKTITSALKTYLRNLPEPLMTYELHNDFinaAKSE 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 660 NDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQ----IQLDIGRMNMLAKVL 735
Cdd:cd04374  121 NLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQEetvaAIMDIKFQNIVVEIL 200

                 ...
gi 221499246 736 IEN 738
Cdd:cd04374  201 IEN 203
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
575-730 6.58e-16

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 76.89  E-value: 6.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 575 VPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDP--RWLKTDDIHTLTSLHKQFFRELTSPLITQEAY 652
Cdd:cd04387   16 VPYIVRQCVEEVER-RGMEEVGIYRISGVATDIQALKAAFDTNNKDvsVMLSEMDVNAIAGTLKLYFRELPEPLFTDELY 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 653 ERL--GRSLNDDAAIERMSLAF-DDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQLDIGRMN 729
Cdd:cd04387   95 PNFaeGIALSDPVAKESCMLNLlLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGPTLLRPSEKESKIPTNT 174

                 .
gi 221499246 730 M 730
Cdd:cd04387  175 M 175
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
558-716 8.10e-16

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 76.19  E-value: 8.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 558 FAAPLSALelnMTDHPNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQ 637
Cdd:cd04406    1 FGVELSRL---TSEDRSVPLVVEKLINYIEM-HGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDYNIHVIASVFKQ 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 638 FFRELTSPLITQEAYERLGRSL---NDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPC 714
Cdd:cd04406   77 WLRDLPNPLMTFELYEEFLRAMglqERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPC 156

                 ..
gi 221499246 715 LL 716
Cdd:cd04406  157 IL 158
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
558-716 2.13e-15

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 75.18  E-value: 2.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 558 FAAPLSALElnmTDHPNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTD-DIHTLTSLHK 636
Cdd:cd04373    1 FGVPLANVV---TSEKPIPIFLEKCVEFIEA-TGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDfTVNAVAGALK 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 637 QFFRELTSPLITQEAYERLGRS--LNDDAA-IERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGP 713
Cdd:cd04373   77 SFFSELPDPLIPYSMHLELVEAakINDREQrLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWP 156

                 ...
gi 221499246 714 CLL 716
Cdd:cd04373  157 TLM 159
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
557-723 5.41e-15

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 74.69  E-value: 5.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 557 LFAAPLSALELN---MTDHPNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKL-THVYDPRWL-KTDDIHTL 631
Cdd:cd04391    1 LFGVPLSTLLERdqkKVPGSKVPLIFQKLINKLEE-RGLETEGILRIPGSAQRVKFLCQELeAKFYEGTFLwDQVKQHDA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 632 TSLHKQFFRELTSPLITQE---AYERLGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLA 708
Cdd:cd04391   80 ASLLKLFIRELPQPLLTVEylpAFYSVQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159
                        170
                 ....*....|....*
gi 221499246 709 IVWGPCLLSANQIQL 723
Cdd:cd04391  160 MIMAPNLFPPRGKHS 174
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
596-720 2.29e-14

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 72.50  E-value: 2.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 596 GLYRASGNKVLVDELRKKLTHVYDPRWLKTD---DIHTLTSLHKQFFRELTSPLITQEAYERLgrslnddaaIERMSLAF 672
Cdd:cd04379   38 GLYRLCGSAAKKKELRDAFERNSAAVELSEElypDINVITGVLKDYLRELPEPLITPQLYEMV---------LEALAVAL 108
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221499246 673 DDMPEPNRS---------------TLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQ 720
Cdd:cd04379  109 PNDVQTNTHltlsiidclplsakaTLLLLLDHLSLVLSNSERNKMTPQNLAVCFGPVLMFCSQ 171
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
595-738 9.45e-14

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 70.11  E-value: 9.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 595 DGLYRASGNKVLVDELRKKLThvydpRWL----KTDDIHTLTSLHKQFFRELTSPLITQEAYER-LGRSLNDDAAIERMS 669
Cdd:cd04389   41 EGIFRVPGDIDEVNELKLRVD-----QWDyplsGLEDPHVPASLLKLWLRELEEPLIPDALYQQcISASEDPDKAVEIVQ 115
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221499246 670 LafddMPEPNRSTLRFLIRHLTRVAAAS--ASNRMPSTNLAIVWGPCLL-----SANQIQLDIGRMNMLAKVLIEN 738
Cdd:cd04389  116 K----LPIINRLVLCYLINFLQVFAQPEnvAHTKMDVSNLAMVFAPNILrctsdDPRVIFENTRKEMSFLRTLIEH 187
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
558-724 1.00e-13

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 70.91  E-value: 1.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 558 FAAPLSaLELNMTDHPnVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQ 637
Cdd:cd04375    5 FGVPLL-VNLQRTGQP-LPRSIQQAMRWLRN-NALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDVADMLKQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 638 FFRELTSPLIT---QEAYERLGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPC 714
Cdd:cd04375   82 YFRDLPEPLLTnklSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLAPS 161
                        170
                 ....*....|
gi 221499246 715 LLSANQIQLD 724
Cdd:cd04375  162 LFHLNTSRRE 171
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
558-721 2.86e-13

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 68.62  E-value: 2.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 558 FAAPLS-ALELNMT-DHPNVPRFVVDVCAYIEQPEcIEQDGLYRASGNKVLVDELRKKLTHVYDPRwLKTDDIHTLTSLH 635
Cdd:cd04381    1 FGASLSlAVERSRChDGIDLPLVFRECIDYVEKHG-MKCEGIYKVSGIKSKVDELKAAYNRRESPN-LEEYEPPTVASLL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 636 KQFFRELTSPLITQEA---YERLGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWG 712
Cdd:cd04381   79 KQYLRELPEPLLTKELmprFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIVLS 158

                 ....*....
gi 221499246 713 PCLLSANQI 721
Cdd:cd04381  159 PTVQISNRL 167
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
584-744 4.05e-13

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 69.03  E-value: 4.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 584 AYIEQPecIEQDGLYRASGNKVLVDELRKKLTHVYD-PRWLKTDDIHTLTSLHKQFFRELTSPLITQEAY---------- 652
Cdd:cd04392   18 EYLEKN--LRVEGLFRKPGNSARQQELRDLLNSGTDlDLESGGFHAHDCATVLKGFLGELPEPLLTHAHYpahlqiadlc 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 653 -----ERLGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCL-----LSANQIQ 722
Cdd:cd04392   96 qfdekGNKTSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLicprnLTPEDLH 175
                        170       180
                 ....*....|....*....|..
gi 221499246 723 LDIGRMNMLAKVLIENYDRIFH 744
Cdd:cd04392  176 ENAQKLNSIVTFMIKHSQKLFK 197
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
575-716 1.22e-12

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 67.47  E-value: 1.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 575 VPrFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYER 654
Cdd:cd04390   22 VP-ILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLLKLYLRELPEPVIPWAQYED 100
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221499246 655 L---GRSLNDDAAIERMSLA--FDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLL 716
Cdd:cd04390  101 FlscAQLLSKDEEKGLGELMkqVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNIL 167
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
558-716 5.92e-12

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 65.60  E-value: 5.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 558 FAAPLSALELNMTDHpnVPrFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQ 637
Cdd:cd04409    1 FGADFAQVAKKSPDG--IP-FIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSELSPHDISNVLKL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 638 FFRELTSPLITQEAYERL---------------------GRSLNDDAAIERMSLAFDDM----PEPNRSTLRFLIRHLTR 692
Cdd:cd04409   78 YLRQLPEPLILFRLYNEFiglakesqhvnetqeakknsdKKWPNMCTELNRILLKSKDLlrqlPAPNYNTLQFLIVHLHR 157
                        170       180
                 ....*....|....*....|....
gi 221499246 693 VAAASASNRMPSTNLAIVWGPCLL 716
Cdd:cd04409  158 VSEQAEENKMSASNLGIIFGPTLI 181
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
575-717 5.75e-09

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 57.03  E-value: 5.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 575 VPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRkkltHVYD--PRWLKTDD-----IHTLTSLHKQFFRELTSPLI 647
Cdd:cd04396   32 IPVVVAKCGVYLKE-NATEVEGIFRVAGSSKRIRELQ----LIFStpPDYGKSFDwdgytVHDAASVLRRYLNNLPEPLV 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 648 TQEAYERLGRSL--------------------NDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNL 707
Cdd:cd04396  107 PLDLYEEFRNPLrkrprilqymkgrineplntDIDQAIKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNL 186
                        170
                 ....*....|
gi 221499246 708 AIVWGPCLLS 717
Cdd:cd04396  187 AAIFQPGILS 196
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
592-736 6.95e-09

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 56.28  E-value: 6.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 592 IEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTD--DIHTLTSLHKQFFRELTSPLITQEAYERLGRSLNDDAAIER-- 667
Cdd:cd04383   34 LQHQGIFRVSGSQVEVNDIKNAFERGEDPLADDQNdhDINSVAGVLKLYFRGLENPLFPKERFEDLMSCVKLENPTERvh 113
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221499246 668 -MSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQLDI---GRMNMLAKVLI 736
Cdd:cd04383  114 qIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGPTLMPVPEGQDQVscqAHVNELIKTII 186
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
575-742 2.12e-08

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 55.06  E-value: 2.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 575 VPRFVVDVCAYIEQPEcIEQDGLYRASGN----KVLVDELRKKLTHVYDprwLKTDDIHTLTSLHKQFFRELTSPLITQE 650
Cdd:cd04397   27 IPALIDDIISAMRQMD-MSVEGVFRKNGNirrlKELTEEIDKNPTEVPD---LSKENPVQLAALLKKFLRELPDPLLTFK 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 651 AYERLGRSLNDDAAIERMS---LAFDDMPEPNRSTLRFLIRHLTRVAAAS-----ASNRMPSTNLAIVWGPCLLSANQIQ 722
Cdd:cd04397  103 LYRLWISSQKIEDEEERKRvlhLVYCLLPKYHRDTMEVLFSFLKWVSSFShideeTGSKMDIHNLATVITPNILYSKTDN 182
                        170       180
                 ....*....|....*....|....
gi 221499246 723 LDIGRMNMLA----KVLIENYDRI 742
Cdd:cd04397  183 PNTGDEYFLAieavNYLIENNEEF 206
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
590-718 7.45e-06

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 47.56  E-value: 7.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 590 ECIEQDGL-----YRASGNKVLVDeLRKKLTHVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYERLGR------S 658
Cdd:cd04388   24 EAIEKKGLesstlYRTQSSSSLTE-LRQILDCDAASVDLEQFDVAALADALKRYLLDLPNPVIPAPVYSEMISraqevqS 102
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 659 LNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSA 718
Cdd:cd04388  103 SDEYAQLLRKLIRSPNLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFSPLLFRF 162
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
607-745 2.61e-03

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 40.01  E-value: 2.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 607 VDELRKKLTHVYDP----RWLKTDDIHTLTSLHKQFFRELTSPLITQEAYERL---------GRSLNDDAAIERMSLAFD 673
Cdd:cd04399   53 THQLRNLLNKPKKPdkevIILKKFEPSTVASVLKLYLLELPDSLIPHDIYDLIrslysayppSQEDSDTARIQGLQSTLS 132
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221499246 674 DMPEPNRSTLRFLIRHLTR---VAAASASNRMPSTNLAIVWGPCLLSAnQIQLDIGRMNMLA-KV---LIENYDRIFHP 745
Cdd:cd04399  133 QLPKSHIATLDAIITHFYRlieITKMGESEEEYADKLATSLSREILRP-IIESLLTIGDKHGyKFfrdLLTHKDQIFSE 210
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
572-717 3.03e-03

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 40.02  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221499246 572 HPNVPRFVVDVCAYIEQPECiEQDGLYRASGnkvLVDELRKKLTHVYDprWLKTD-------DIHTL--TSLHkqFFREL 642
Cdd:cd04380   47 PLSIPKEIWRLVDYLYTRGL-AQEGLFEEPG---LPSEPGELLAEIRD--ALDTGspfnspgSAESVaeALLL--FLESL 118
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221499246 643 TSPLITQEAYERL--GRSLNDDAAIERMSLAfddMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLS 717
Cdd:cd04380  119 PDPIIPYSLYERLleAVANNEEDKRQVIRIS---LPPVHRNVFVYLCSFLRELLSESADRGLDENTLATIFGRVLLR 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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