RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 292 PRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYERL 371
Cdd:cd00159   1 PLIIEKCIEYLEK-NGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 372 ---GRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLL----SANQIQLDIGRM 444
Cdd:cd00159  80 ielAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLrppdSDDELLEDIKKL 159

                       170
                ....*....|
gi 24643174 445 NMLAKVLIEN 454
Cdd:cd00159 160 NEIVEFLIEN 169

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 292 PRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYERL 371
Cdd:cd00159   1 PLIIEKCIEYLEK-NGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 372 ---GRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLL----SANQIQLDIGRM 444
Cdd:cd00159  80 ielAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLrppdSDDELLEDIKKL 159

                       170
                ....*....|
gi 24643174 445 NMLAKVLIEN 454
Cdd:cd00159 160 NEIVEFLIEN 169

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 274 FAAPLSALELNmtDHPNVPRfVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRK-------KLTHVYDPRWLktDDIHT 346
Cdd:cd04398   1 FGVPLEDLILR--EGDNVPN-IVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKElfdkdplNVLLISPEDYE--SDIHS 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 347 LTSLHKQFFRELTSPLITQEAYERLGRSLN-DDAAIERMSL--AFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNL 423
Cdd:cd04398  76 VASLLKLFFRELPEPLLTKALSREFIEAAKiEDESRRRDALhgLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNL 155

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 24643174 424 AIVWGPCLLSANQIQL-DIGRMNMLAKVLIENYDRIF 459
Cdd:cd04398 156 AIIWGPTLMNAAPDNAaDMSFQSRVIETLLDNAYQIF 192

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 289 PNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQFFRELTSPLIT---Q 365
Cdd:cd04382  15 PMIPALIVHCVNEIEA-RGLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVICGCLKDFLRSLKEPLITfalW 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 366 EAYERLGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASAsNRMPSTNLAIVWGPCLLSANQIQLDigRMN 445
Cdd:cd04382  94 KEFMEAAEILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQSPE-CKMDINNLARVFGPTIVGYSVPNPD--PMT 170

                ....*
gi 24643174 446 MLAKV 450
Cdd:cd04382 171 ILQDT 175

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 274 FAAPLSALelnMTDHPNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHvyDPRWLKTDD--IHTLTSLH 351
Cdd:cd04377   1 FGVSLSSL---TSEDRSVPLVLEKLLEHIEM-HGLYTEGIYRKSGSANKIKELRQGLDT--DPDSVNLEDypIHVITSVL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 352 KQFFRELTSPLITQEAYERLGRSLNDDAAIER---MSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWG 428
Cdd:cd04377  75 KQWLRELPEPLMTFELYENFLRAMELEEKQERvraLYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFA 154

                       170       180       190
                ....*....|....*....|....*....|.
gi 24643174 429 PCLLSAN-----QIQL-DIGRMNMLAKVLIE 453
Cdd:cd04377 155 PCILRCPdtadpLQSLqDVSKTTTCVETLIK 185

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 273 LFAAPLSALEL-NMTDHPNVPRFVVDVCAYIEQPecIEQDGLYRASGNKVLVDELRKKLTHVYDPrwLKTDDIHTLTSLH 351
Cdd:cd04394   1 VFGVPLHSLPHsTVPEYGNVPKFLVDACTFLLDH--LSTEGLFRKSGSVVRQKELKAKLEGGEAC--LSSALPCDVAGLL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 352 KQFFRELTSPLIT---QEAYERLGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWG 428
Cdd:cd04394  77 KQFFRELPEPLLPydlHEALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFA 156

                ....*..
gi 24643174 429 PCLLSAN 435
Cdd:cd04394 157 PNLFQSE 163

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 272 PLFAAPLSALELNMTDHPNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLH 351
Cdd:cd04393   1 KVFGVPLQELQQAGQPENGVPAVVRHIVEYLEQ-HGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 352 KQFFRELTSPLITQEAYERLGR----SLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVW 427
Cdd:cd04393  80 RLFLQELPEGLIPASLQIRLMQlyqdYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAVF 159

                ....
gi 24643174 428 GPCL 431
Cdd:cd04393 160 GPDV 163

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 290 NVPrFVVDVC-AYIEQpECIEQDGLYRASGNKVLVDELRKKLTHvyDPRWLK----TDDIHTLTSLHKQFFRELTSPLIT 364
Cdd:cd04385  14 DIP-VIVDKCiDFITQ-HGLMSEGIYRKNGKNSSVKKLLEAFRK--DARSVQlregEYTVHDVADVLKRFLRDLPDPLLT 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 365 QEAYERLGRSL---NDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQldI 441
Cdd:cd04385  90 SELHAEWIEAAeleNKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQTDEHS--V 167

                       170
                ....*....|....*..
gi 24643174 442 GRMNMLAKV---LIENY 455
Cdd:cd04385 168 GQTSHEVKViedLIDNY 184

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 311 DGLYRASGNKVLVDELRKKLTHvyDPRWLKTDD--IHTLTSLHKQFFRELTSPLITQEAYERLGRSLNDDAAIERMSLAF 388
Cdd:cd04407  34 EGIYRKSGSANRMKELHQLLQA--DPENVKLENypIHAITGLLKQWLRELPEPLMTFAQYNDFLRAVELPEKQEQLQAIY 111

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 24643174 389 ---DDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLL 432
Cdd:cd04407 112 rvlEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPCLL 158

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 291 VPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYER 370
Cdd:cd04408  16 VPFVVVRCTAEIEN-RALGVQGIYRISGSKARVEKLCQAFENGRDLVDLSGHSPHDITSVLKHFLKELPEPVLPFQLYDD 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 371 ---LGRSLNDDA------------AIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLL--- 432
Cdd:cd04408  95 fiaLAKELQRDSekaaespsivenIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPTLLrpl 174

                       170       180
                ....*....|....*....|....*.
gi 24643174 433 SANQIQ----LDIGRMNMLAKVLIEN 454
Cdd:cd04408 175 VGGDVSmiclLDTGYQAQLVEFLISN 200

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 273 LFAAPLSALelnMTDHpNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKL---THVYdprwLKTDDIHTLTS 349
Cdd:cd04402   1 LFGQPLSNI---CEDD-NLPKPILDMLSLLYQ-KGPSTEGIFRRSANAKACKELKEKLnsgVEVD----LKAEPVLLLAS 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 350 LHKQFFRELTSPLITQEAYERLGRSLNDDAAIERMS----LAfDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAI 425
Cdd:cd04402  72 VLKDFLRNIPGSLLSSDLYEEWMSALDQENEEEKIAelqrLL-DKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAV 150

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 24643174 426 VWGPCLLSANQIQLDIGRMN----MLAKVLIENYDRIF 459
Cdd:cd04402 151 CIAPSLLWPPASSELQNEDLkkvtSLVQFLIENCQEIF 188

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 308 IEQDGLYRASGNKVLVDELrkkLTHVYDPRW-------LKTD--DIHTLTSLHKQFFRELTSPLITQEAYERL---GRSL 375
Cdd:cd04374  44 INEQGLYRVVGVNSKVQKL---LSLGLDPKTstpgdvdLDNSewEIKTITSALKTYLRNLPEPLMTYELHNDFinaAKSE 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 376 NDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQ----IQLDIGRMNMLAKVL 451
Cdd:cd04374 121 NLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQEetvaAIMDIKFQNIVVEIL 200

                ...
gi 24643174 452 IEN 454
Cdd:cd04374 201 IEN 203

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 274 FAAPLSALelnMTDHPNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQ 353
Cdd:cd04406   1 FGVELSRL---TSEDRSVPLVVEKLINYIEM-HGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDYNIHVIASVFKQ 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 354 FFRELTSPLITQEAYERLGRSL---NDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPC 430
Cdd:cd04406  77 WLRDLPNPLMTFELYEEFLRAMglqERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPC 156

                ..
gi 24643174 431 LL 432
Cdd:cd04406 157 IL 158

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 273 LFAAPLSALELN---MTDHPNVPRFVVDVCAYIEQpECIEQDGLYRASGNKVLVDELRKKL-THVYDPRWL-KTDDIHTL 347
Cdd:cd04391   1 LFGVPLSTLLERdqkKVPGSKVPLIFQKLINKLEE-RGLETEGILRIPGSAQRVKFLCQELeAKFYEGTFLwDQVKQHDA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 348 TSLHKQFFRELTSPLITQE---AYERLGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLA 424
Cdd:cd04391  80 ASLLKLFIRELPQPLLTVEylpAFYSVQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                       170
                ....*....|....*
gi 24643174 425 IVWGPCLLSANQIQL 439
Cdd:cd04391 160 MIMAPNLFPPRGKHS 174

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 311 DGLYRASGNKVLVDELRKKLThvydpRWL----KTDDIHTLTSLHKQFFRELTSPLITQEAYER-LGRSLNDDAAIERMS 385
Cdd:cd04389  41 EGIFRVPGDIDEVNELKLRVD-----QWDyplsGLEDPHVPASLLKLWLRELEEPLIPDALYQQcISASEDPDKAVEIVQ 115

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24643174 386 LafddMPEPNRSTLRFLIRHLTRVAAAS--ASNRMPSTNLAIVWGPCLL-----SANQIQLDIGRMNMLAKVLIEN 454
Cdd:cd04389 116 K----LPIINRLVLCYLINFLQVFAQPEnvAHTKMDVSNLAMVFAPNILrctsdDPRVIFENTRKEMSFLRTLIEH 187

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 274 FAAPLS-ALELNMT-DHPNVPRFVVDVCAYIEQPEcIEQDGLYRASGNKVLVDELRKKLTHVYDPRwLKTDDIHTLTSLH 351
Cdd:cd04381   1 FGASLSlAVERSRChDGIDLPLVFRECIDYVEKHG-MKCEGIYKVSGIKSKVDELKAAYNRRESPN-LEEYEPPTVASLL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 352 KQFFRELTSPLITQEA---YERLGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWG 428
Cdd:cd04381  79 KQYLRELPEPLLTKELmprFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIVLS 158

                ....*....
gi 24643174 429 PCLLSANQI 437
Cdd:cd04381 159 PTVQISNRL 167

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 291 VPrFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYER 370
Cdd:cd04390  22 VP-ILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLLKLYLRELPEPVIPWAQYED 100

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24643174 371 L---GRSLNDDAAIERMSLA--FDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLL 432
Cdd:cd04390 101 FlscAQLLSKDEEKGLGELMkqVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNIL 167

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643174 308 IEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTD--DIHTLTSLHKQFFRELTSPLITQEAYERLGRSLNDDAAIER-- 383
Cdd:cd04383  34 LQHQGIFRVSGSQVEVNDIKNAFERGEDPLADDQNdhDINSVAGVLKLYFRGLENPLFPKERFEDLMSCVKLENPTERvh 113

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24643174 384 -MSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQLDI---GRMNMLAKVLI 452
Cdd:cd04383 114 qIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGPTLMPVPEGQDQVscqAHVNELIKTII 186