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RpL21 Ribosomal protein L21 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35453, updated on 4-Jan-2025

Summary

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Official Symbol
RpL21provided by FlyBase
Official Full Name
Ribosomal protein L21provided by FlyBase
Primary source
FLYBASE:FBgn0032987
Locus tag
Dmel_CG12775
See related
AllianceGenome:FB:FBgn0032987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey18; anon-EST:Posey30; BcDNA:RH06526; CG12775; Dmel\CG12775; L21e; Rp L21; RPL21
Summary
A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in hypotrichosis 12. Orthologous to human RPL21 (ribosomal protein L21). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See RpL21 in Genome Data Viewer
Location:
40F6-40F6; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22247111..22247875, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22247111..22247875, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43765 Neighboring gene NUBP iron-sulfur cluster assembly factor, mitochondrial Neighboring gene Tif-IA Neighboring gene Meiosis regulator and mRNA stability factor 1 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity. Pinnola A, et al. J Biol Chem, 2007 Nov 2. PMID 17827147
  2. Identifying new players in structural synaptic plasticity through dArc1 interrogation. Xiao C, et al. iScience, 2023 Nov 17. PMID 37876812, Free PMC Article
  3. Genetic analysis of RpL38 and RpL5, two minute genes located in the centric heterochromatin of chromosome 2 of Drosophila melanogaster. Marygold SJ, et al. Genetics, 2005 Feb. PMID 15520262, Free PMC Article
  4. Adaptation of gene loci to heterochromatin in the course of Drosophila evolution is associated with insulator proteins. Funikov SY, et al. Sci Rep, 2020 Jul 17. PMID 32681087, Free PMC Article
  5. Characterization of the Drosophila melanogaster ribosomal proteome. Alonso J, et al. J Proteome Res, 2006 Aug. PMID 16889426

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation TAS
Traceable Author Statement
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosolic ribosome HDA PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal protein L21
Names
CG12775-PA
CG12775-PB
CG12775-PC
RpL21-PA
RpL21-PB
RpL21-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    22247111..22247875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273760.1 → NP_001260689.1  ribosomal protein L21, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260689.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V9M7
    Conserved Domains (1) summary
    PTZ00189
    Location:1 → 159
    PTZ00189; 60S ribosomal protein L21; Provisional

  2. NM_001299204.1 → NP_001286133.1  ribosomal protein L21, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286133.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V9M7
    Conserved Domains (1) summary
    PTZ00189
    Location:1 → 159
    PTZ00189; 60S ribosomal protein L21; Provisional

  3. NM_136300.3 → NP_610144.1  ribosomal protein L21, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610144.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V9M7
    Related
    FBpp0085314
    Conserved Domains (1) summary
    PTZ00189
    Location:1 → 159
    PTZ00189; 60S ribosomal protein L21; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V9M7 Q9V9M7

Gene LinkOut

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