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sec-23 Protein transport protein SEC23 [ Caenorhabditis elegans ]

Gene ID: 180317, updated on 9-Dec-2024

Summary

Official Symbol
sec-23
Official Full Name
Protein transport protein SEC23
Primary source
WormBase:WBGene00004754
Locus tag
CELE_Y113G7A.3
See related
AllianceGenome:WB:WBGene00004754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in COPII-coated vesicle cargo loading. Located in endoplasmic reticulum exit site. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in Cowden syndrome 7; congenital dyserythropoietic anemia type II; and craniolenticulosutural dysplasia. Orthologous to several human genes including SEC23B (SEC23 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See sec-23 in Genome Data Viewer
Location:
chromosome: V
Exon count:
12
Sequence:
Chromosome: V; NC_003283.11 (20091263..20105685)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene NADPH-dependent diflavin oxidoreductase 1 Neighboring gene ncRNA Neighboring gene 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;m7GpppX diphosphatase Neighboring gene Neuropeptide-Like Protein Neighboring gene Calx-beta domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity  
enables metal ion binding  
enables zinc ion binding  
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
involved_in intracellular protein transport  
involved_in protein transport  
involved_in vesicle-mediated transport  
Component Evidence Code Pubs
part_of COPII vesicle coat  
part_of COPII vesicle coat  
located_in ER to Golgi transport vesicle membrane  
located_in cytoplasm  
located_in cytoplasmic vesicle  
located_in endoplasmic reticulum  
is_active_in endoplasmic reticulum exit site  
located_in endoplasmic reticulum exit site PubMed 
located_in endoplasmic reticulum membrane  
located_in membrane  

General protein information

Preferred Names
Protein transport protein SEC23
NP_507877.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20091263..20105685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075476.8NP_507877.1  Protein transport protein SEC23 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507877.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U2Z1
    Conserved Domains (6) summary
    cd11287
    Location:668788
    Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
    PLN00162
    Location:12811
    PLN00162; transport protein sec23; Provisional
    cd01478
    Location:130445
    Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam04810
    Location:62101
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:590673
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:458561
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
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