unc-18 Acetylcholine regulator unc-18 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-18
Official Full Name: Acetylcholine regulator unc-18
Primary source: WormBase:WBGene00006757
Locus tag: CELE_F27D9.1
See related: AllianceGenome:WB:WBGene00006757
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables syntaxin binding activity. Involved in chemical synaptic transmission and positive regulation of neurotransmitter secretion. Located in axon. Is expressed in intestine; nervous system; and uv1. Used to study alcohol use disorder and developmental and epileptic encephalopathy. Human ortholog(s) of this gene implicated in West syndrome; developmental and epileptic encephalopathy 4; and familial hemophagocytic lymphohistiocytosis 5. Orthologous to several human genes including STXBP1 (syntaxin binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See unc-18 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (7682896..7686037)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression and function of Caenorhabditis elegans UNCP-18, a paralog of the SM protein UNC-18.
Title: Expression and function of Caenorhabditis elegans UNCP-18, a paralog of the SM protein UNC-18.
Thus, our study provides novel mechanistic insights into how Munc18/UNC-18 primes synaptic vesicle release and how this protein interacts functionally with Munc13/UNC-13 and Tomosyn/TOM-1.
Title: UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.
data demonstrate that an individual DAG-dependent thermosensory behavior of an organism is effected specifically by the downstream PKC-2 phosphorylation of UNC-18 on Ser322 in AFD neurons.
Title: PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion.
data implicate a novel role for an exposed loop in domain 3b of Munc18-1 in transducing regulation of vesicle fusion independent of closed-conformation syntaxin binding
Title: Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis.
Data show that the syntaxin N-peptide is an initiation factor for the assembly of the SNARE-SM membrane fusion complex.
Title: Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex.
Results suggest that ethanol acts, at least partially, at the level of exocytotic vesicle fusion and that its acute effects are ameliorated by point mutations in UNC-18.
Title: UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans.
UNC-18 acts as a molecular chaperone for Syntaxin transport in neurons
Title: UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin.
binding of UNC-18 to closed syntaxin is dispensable for membrane fusion, whereas interaction with the syntaxin N-terminus is essential for neuronal exocytosis in vivo
Title: Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans.
A reduction of docked synaptic vesicles at the active zone occurs in UNC-18 mutants, suggesting that UNC-18 functions, directly or indirectly, as a facilitator of vesicle docking.
Title: Defects in synaptic vesicle docking in unc-18 mutants.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F27D9.1 (e-PCR)
- UniSTS:312304

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IBA Inferred from Biological aspect of Ancestor more info
enables syntaxin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic dense core vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in presynaptic dense core vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic dense core vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle docking	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle docking involved in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info