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tfg-1 Protein tfg-1 [ Caenorhabditis elegans ]

Gene ID: 173277, updated on 2-Nov-2024

Summary

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Official Symbol
tfg-1
Official Full Name
Protein tfg-1
Primary source
WormBase:WBGene00006565
Locus tag
CELE_Y63D3A.5
See related
AllianceGenome:WB:WBGene00006565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable identical protein binding activity. Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; maintenance of protein localization in organelle; and protein secretion. Located in endoplasmic reticulum exit site and mitochondrion. Is expressed in germ line; hypodermis; intestine; and muscle cell. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 57. Orthologous to human TFG (trafficking from ER to golgi regulator). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tfg-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (14101322..14104470)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box associated domain-containing protein Neighboring gene ncRNA Neighboring gene 5'-tyrosyl-DNA phosphodiesterase Neighboring gene J domain-containing protein Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments. Hanna MG 4th, et al. Proc Natl Acad Sci U S A, 2017 Sep 12. PMID 28851831, Free PMC Article
  2. TFG clusters COPII-coated transport carriers and promotes early secretory pathway organization. Johnson A, et al. EMBO J, 2015 Mar 12. PMID 25586378, Free PMC Article
  3. ced-4 and proto-oncogene tfg-1 antagonistically regulate cell size and apoptosis in C. elegans. Chen L, et al. Curr Biol, 2008 Jul 22. PMID 18635357, Free PMC Article
  4. TFG-1 function in protein secretion and oncogenesis. Witte K, et al. Nat Cell Biol, 2011 May. PMID 21478858, Free PMC Article
  5. A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode. Tsushima H, et al. PLoS One, 2013. PMID 23424658, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in COPII vesicle coating IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of protein localization in organelle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein tfg-1
NP_493462.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14101322..14104470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061061.8 → NP_493462.1  Protein tfg-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493462.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U1W1
    Conserved Domains (1) summary
    smart00666
    Location:10 → 89
    PB1; PB1 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U1W1.1

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