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wupA wings up A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32794, updated on 27-Dec-2024

Summary

Official Symbol
wupAprovided by FlyBase
Official Full Name
wings up Aprovided by FlyBase
Primary source
FLYBASE:FBgn0283471
Locus tag
Dmel_CG7178
See related
AllianceGenome:FB:FBgn0283471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7178; chrX:17947374..17947524; Dmel\CG7178; DmTpnI; DROTROPONI; fliH; hdp; Hdp; HDP; hdp-a; hdp2; HL-I; HL08042; HLI; Tn I; TnI; TpnI; wup-A; wupa; WupA
Summary
Involved in several processes, including adult somatic muscle development; muscle cell cellular homeostasis; and sarcomere organization. Located in striated muscle thin filament. Colocalizes with nucleus. Is expressed in several structures, including adult head; adult heart; larval muscle system; mesoderm; and muscle cell. Used to study adenocarcinoma; cardiomyopathy; dilated cardiomyopathy; and heart disease. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; distal arthrogryposis type 2B1; and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including TNNI3 (troponin I3, cardiac type). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See wupA in Genome Data Viewer
Location:
16F7-16F7; 1-59 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18105568..18116922, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17999601..18010955, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene TBP-associated factor 8 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45605 Neighboring gene long non-coding RNA:CR45606

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
colocalizes_with nucleus PubMed 
located_in striated muscle thin filament PubMed 
part_of troponin complex  
part_of troponin complex  
part_of troponin complex PubMed 

General protein information

Preferred Names
wings up A
Names
CG7178-PA
CG7178-PB
CG7178-PC
CG7178-PD
CG7178-PE
CG7178-PF
CG7178-PG
CG7178-PH
CG7178-PI
CG7178-PJ
CG7178-PK
CG7178-PL
CG7178-PM
flightless H
flightless-H
haplo-lethal region I
held up
held-up
held-up2
heldup
heldup-a
troponin
troponin I
troponin-I
wings up
wings-up A
wupA-PA
wupA-PB
wupA-PC
wupA-PD
wupA-PE
wupA-PF
wupA-PG
wupA-PH
wupA-PI
wupA-PJ
wupA-PK
wupA-PL
wupA-PM

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    18105568..18116922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167604.4 → NP_728138.1  wings up A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728138.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P36188
    Related
    FBpp0074297
    Conserved Domains (1) summary
    pfam00992
    Location:55 → 172
    Troponin
  2. NM_001272740.2 → NP_001259669.1  wings up A, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259669.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PJQ5
    Conserved Domains (1) summary
    pfam00992
    Location:31 → 148
    Troponin; Troponin
  3. NM_078674.4 → NP_523398.1  wings up A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523398.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4Q6
    Related
    FBpp0074296
    Conserved Domains (1) summary
    pfam00992
    Location:55 → 172
    Troponin
  4. NM_167606.3 → NP_728140.1  wings up A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728140.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKJ4
    Related
    FBpp0074295
    Conserved Domains (1) summary
    pfam00992
    Location:55 → 172
    Troponin; Troponin
  5. NM_167607.3 → NP_728141.1  wings up A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728141.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKM1
    Related
    FBpp0074294
    Conserved Domains (1) summary
    pfam00992
    Location:55 → 172
    Troponin
  6. NM_167608.3 → NP_728142.1  wings up A, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728142.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P36188, Q0KHR0, Q9VWY1, Q9VWY2, Q9VWY3, Q9VWY4
    Related
    FBpp0074298
    Conserved Domains (1) summary
    pfam00992
    Location:116 → 233
    Troponin
  7. NM_001272741.1 → NP_001259670.1  wings up A, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259670.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PJQ5
    Conserved Domains (1) summary
    pfam00992
    Location:31 → 148
    Troponin; Troponin
  8. NM_001272739.1 → NP_001259668.1  wings up A, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259668.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PJQ5
    Conserved Domains (1) summary
    pfam00992
    Location:31 → 148
    Troponin; Troponin
  9. NM_167603.3 → NP_728137.1  wings up A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728137.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4Q6
    Related
    FBpp0074299
    Conserved Domains (1) summary
    pfam00992
    Location:55 → 172
    Troponin
  10. NM_167605.3 → NP_728139.1  wings up A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728139.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P36188
    Related
    FBpp0074300
    Conserved Domains (1) summary
    pfam00992
    Location:55 → 172
    Troponin
  11. NM_001258805.2 → NP_001245734.1  wings up A, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245734.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NH88
    Conserved Domains (1) summary
    pfam00992
    Location:55 → 172
    Troponin
  12. NM_001258804.2 → NP_001245733.1  wings up A, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245733.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFC0
    Conserved Domains (1) summary
    pfam00992
    Location:55 → 172
    Troponin
  13. NM_001258803.2 → NP_001245732.1  wings up A, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245732.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKJ3
    Conserved Domains (1) summary
    pfam00992
    Location:116 → 233
    Troponin
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