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Lasp lasp [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39864, updated on 9-Dec-2024

Summary

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Official Symbol
Laspprovided by FlyBase
Official Full Name
laspprovided by FlyBase
Primary source
FLYBASE:FBgn0063485
Locus tag
Dmel_CG3849
See related
AllianceGenome:FB:FBgn0063485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-73Bd; cDNA B; CG3849; Dmel\CG3849; lasp
Summary
Enables actin binding activity. Involved in several processes, including cellularization; myofibril assembly; and positive regulation of pole plasm oskar mRNA localization. Located in focal adhesion; sarcomere; and sperm individualization complex. Is expressed in several structures, including adult brain; adult gnathal ganglion; adult head; germline cell; and somatic cell of ovariole. Orthologous to human LASP1 (LIM and SH3 protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Lasp in Genome Data Viewer
Location:
73B6-73C1; 3-44 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16676406..16711677, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16669506..16704777, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Coat Protein (coatomer) zeta Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45179 Neighboring gene long non-coding RNA:CR45897 Neighboring gene uncharacterized protein Neighboring gene Disabled Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LIM and SH3 protein 1 (LASP-1): A novel link between the slit membrane and actin cytoskeleton dynamics in podocytes. Lepa C, et al. FASEB J, 2020 Apr. PMID 32086849
  2. LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development. Pollitt SL, et al. Mol Biol Cell, 2020 Nov 15. PMID 32997597, Free PMC Article
  3. Reduced expression of CDP-DAG synthase changes lipid composition and leads to male sterility in Drosophila. Laurinyecz B, et al. Open Biol, 2016 Jan. PMID 26791243, Free PMC Article
  4. The actin-binding protein Lasp promotes Oskar accumulation at the posterior pole of the Drosophila embryo. Suyama R, et al. Development, 2009 Jan. PMID 19036801
  5. Lasp anchors the Drosophila male stem cell niche and mediates spermatid individualization. Lee S, et al. Mech Dev, 2008 Sep-Oct. PMID 18655828

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lasp, the only member of the nebulin family in Drosophila melanogaster, acts at two distinct sites in the sarcomere and controls thin filament length with just two nebulin repeats.
    Title: The nebulin repeat protein Lasp regulates I-band architecture and filament spacing in myofibrils.
  2. The Drosophila homolog of mammalian Lasp1 protein, an actin-binding protein previously implicated in cell migration in vertebrate cell culture, contributes to the accumulation of Oskar protein at the posterior pole of the embryo.
    Title: The actin-binding protein Lasp promotes Oskar accumulation at the posterior pole of the Drosophila embryo.
  3. Lasp functions together with integrins in hub cells to anchor the stem cell niche.
    Title: Lasp anchors the Drosophila male stem cell niche and mediates spermatid individualization.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in muscle thin filament assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pole cell formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of pole plasm oskar mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of myofibril size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in A band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm individualization complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lasp
Names
CG3849-PA
CG3849-PB
CG3849-PC
CG3849-PD
Lasp-PA
Lasp-PB
Lasp-PC
Lasp-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16676406..16711677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168681.4 → NP_730192.2  lasp, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730192.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q59E31, Q8I7C3, Q9VV91
    Conserved Domains (4) summary
    smart00227
    Location:97 → 127
    NEBU; The Nebulin repeat is present also in Las1
    cd09447
    Location:5 → 57
    LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
    cd11789
    Location:600 → 654
    SH3_Nebulin_family_C; C-terminal Src Homology 3 domain of the Nebulin family of proteins
    pfam00880
    Location:68 → 94
    Nebulin; Nebulin repeat

  2. NM_001259870.2 → NP_001246799.1  lasp, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246799.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFH3
    Conserved Domains (4) summary
    smart00227
    Location:97 → 127
    NEBU; The Nebulin repeat is present also in Las1
    cd09447
    Location:5 → 57
    LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
    cd11789
    Location:225 → 279
    SH3_Nebulin_family_C; C-terminal Src Homology 3 domain of the Nebulin family of proteins
    pfam00880
    Location:68 → 94
    Nebulin; Nebulin repeat

  3. NM_140655.3 → NP_648912.2  lasp, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648912.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8I7C3
    Related
    FBpp0075109
    Conserved Domains (4) summary
    smart00227
    Location:97 → 127
    NEBU; The Nebulin repeat is present also in Las1
    cd09447
    Location:5 → 57
    LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
    cd11789
    Location:447 → 501
    SH3_Nebulin_family_C; C-terminal Src Homology 3 domain of the Nebulin family of proteins
    pfam00880
    Location:68 → 94
    Nebulin; Nebulin repeat

  4. NM_001259869.2 → NP_001246798.1  lasp, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246798.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDA6
    Conserved Domains (4) summary
    smart00227
    Location:97 → 127
    NEBU; The Nebulin repeat is present also in Las1
    cd09447
    Location:5 → 57
    LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
    cd11789
    Location:579 → 633
    SH3_Nebulin_family_C; C-terminal Src Homology 3 domain of the Nebulin family of proteins
    pfam00880
    Location:68 → 94
    Nebulin; Nebulin repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NDA6 M9NDA6
M9NFH3 M9NFH3
Q8I7C3.2 Q8I7C3

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