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    AlaRS Alanyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34156, updated on 9-Dec-2024

    Summary

    Official Symbol
    AlaRSprovided by FlyBase
    Official Full Name
    Alanyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027094
    Locus tag
    Dmel_CG13391
    See related
    AllianceGenome:FB:FBgn0027094
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AARS; Aats-ala; alaS; ARS; CG13391; dAARS; Dmel\CG13391
    Summary
    Predicted to enable alanine-tRNA ligase activity and aminoacyl-tRNA editing activity. Predicted to be involved in alanyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic head epidermis; embryonic/larval midgut primordium; and mesoderm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2N; developmental and epileptic encephalopathy 29; leukodystrophy; and trichothiodystrophy. Orthologous to human AARS1 (alanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See AlaRS in Genome Data Viewer
    Location:
    29B3-29B3; 2-31 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8378262..8381764, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8378262..8381764, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene WD repeat domain 82 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Reduction in Cnn dots 4 Neighboring gene Defender against apoptotic cell death 1

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables alanine-tRNA ligase activity  
    enables alanine-tRNA ligase activity  
    enables alanine-tRNA ligase activity  
    enables alanine-tRNA ligase activity PubMed 
    enables aminoacyl-tRNA editing activity  
    enables nucleic acid binding  
    Process Evidence Code Pubs
    involved_in alanyl-tRNA aminoacylation  
    involved_in alanyl-tRNA aminoacylation  
    involved_in alanyl-tRNA aminoacylation  
    involved_in alanyl-tRNA aminoacylation PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    Alanyl-tRNA synthetase
    Names
    AlaRS-PA
    AlaRS-PB
    CG13391-PA
    CG13391-PB
    NP_523511.2
    NP_995656.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8378262..8381764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078787.4 → NP_523511.2  Alanyl-tRNA synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523511.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T9K4, Q9U6B4, Q9VLM8
      UniProtKB/TrEMBL
      T2FFB7
      Related
      FBpp0079326
      Conserved Domains (5) summary
      PLN02900
      Location:5 → 963
      PLN02900; alanyl-tRNA synthetase
      cd00673
      Location:6 → 253
      AlaRS_core; Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      pfam02272
      Location:888 → 957
      DHHA1; DHHA1 domain
      pfam07973
      Location:694 → 752
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cl08469
      Location:529 → 626
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    2. NM_205934.3 → NP_995656.1  Alanyl-tRNA synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995656.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T9K4, Q9U6B4, Q9VLM8
      UniProtKB/TrEMBL
      T2FFB7
      Conserved Domains (5) summary
      PLN02900
      Location:5 → 963
      PLN02900; alanyl-tRNA synthetase
      cd00673
      Location:6 → 253
      AlaRS_core; Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      pfam02272
      Location:888 → 957
      DHHA1; DHHA1 domain
      pfam07973
      Location:694 → 752
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cl08469
      Location:529 → 626
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
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