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Orco Odorant receptor co-receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40650, updated on 4-Jan-2025

Summary

Official Symbol
Orcoprovided by FlyBase
Official Full Name
Odorant receptor co-receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0037324
Locus tag
Dmel_CG10609
See related
AllianceGenome:FB:FBgn0037324
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
83A.2; 83b; A45; CG10609; DmelOrco; Dmel\CG10609; DmOrco; DmORCO; DOR45; DOR83b; OR49; or83b; Or83b; OR83b; OR83B; orco; OrCo; ORCO; vainsA
Summary
Enables several functions, including calmodulin binding activity; coreceptor activity; and protein homodimerization activity. Contributes to ionotropic olfactory receptor activity. Involved in several processes, including behavioral response to ethanol; detection of chemical stimulus involved in sensory perception of smell; and olfactory behavior. Located in cilium; dendrite; and plasma membrane. Part of cation channel complex. Is expressed in several structures, including adult brain; adult head sensillum; antennal lobe; olfactory receptor neurons; and organism subdivision. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Orco in Genome Data Viewer
Location:
83A2-83A2; 3-47.5 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5407183..5412406, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1232905..1238128, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 83a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pancreatic eIF-2alpha kinase

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calmodulin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calmodulin binding ISM
Inferred from Sequence Model
more info
PubMed 
enables coreceptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables intracellularly gated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ionotropic olfactory receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ionotropic olfactory receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ionotropic olfactory receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables odorant binding IEA
Inferred from Electronic Annotation
more info
 
enables odorant binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables odorant binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables olfactory receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables olfactory receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of cation channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cation channel complex TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in dendrite membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IC
Inferred by Curator
more info
PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
odorant receptor co-receptor
Names
CG10609-PA
CG10609-PB
Or83b
Orco-PA
Orco-PB
odorant receptor 83b
odorant receptor coreceptor
olfactory co-receptor
olfactory coreceptor
olfactory receptor co-receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5407183..5412406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104217.2NP_001097687.1  odorant receptor co-receptor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097687.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8JQT8, Q672R0, Q9VNB5
    UniProtKB/TrEMBL
    G2J620
    Conserved Domains (1) summary
    pfam02949
    Location:70472
    7tm_6; 7tm Odorant receptor
  2. NM_079511.5NP_524235.2  odorant receptor co-receptor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524235.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8JQT8, Q672R0, Q9VNB5
    UniProtKB/TrEMBL
    G2J620
    Related
    FBpp0078438
    Conserved Domains (1) summary
    pfam02949
    Location:70472
    7tm_6; 7tm Odorant receptor