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Vinc Vinculin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31201, updated on 17-Dec-2024

Summary

Official Symbol
Vincprovided by FlyBase
Official Full Name
Vinculinprovided by FlyBase
Primary source
FLYBASE:FBgn0004397
Locus tag
Dmel_CG3299
See related
AllianceGenome:FB:FBgn0004397
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3299; CT11081; Dmel\CG3299; Dmvincp; EG:103B4.1; Vin; Vin2EF; vinc; VINC
Summary
Predicted to enable alpha-catenin binding activity and beta-catenin binding activity. Predicted to be involved in cell adhesion. Located in cytoplasmic side of apical plasma membrane. Is expressed in several structures, including adult head; adult heart; gut section; larval muscle system; and spermatozoon. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Vinc in Genome Data Viewer
Location:
2E2-2E3; 1-0.8 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2214347..2222567, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2108380..2116600, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Monocarboxylate transporter 1 Neighboring gene antisense RNA:CR43637 Neighboring gene Fatty acyl-CoA reductase in oenocytes Neighboring gene SET and MYND domain containing, arthropod-specific, member 8 Neighboring gene uncharacterized protein Neighboring gene pecanex Neighboring gene kurz

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin filament binding  
enables alpha-catenin binding  
enables beta-catenin binding  
enables structural molecule activity  
Process Evidence Code Pubs
involved_in cell adhesion  
involved_in cell adhesion  
Component Evidence Code Pubs
located_in actin cytoskeleton  
is_active_in adherens junction  
is_active_in cell-cell contact zone  
is_active_in cytoplasm  
located_in cytoplasmic side of apical plasma membrane PubMed 
is_active_in cytoskeleton  
is_active_in focal adhesion  
located_in focal adhesion PubMed 
is_active_in plasma membrane  

General protein information

Preferred Names
vinculin
Names
CG3299-PA
CG3299-PB
CG3299-PC
Vinc-PA
Vinc-PB
Vinc-PC
vinculin at 2EF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2214347..2222567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297884.1 → NP_001284813.1  vinculin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284813.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46037
    UniProtKB/TrEMBL
    Q24584, X2JAB9
    Conserved Domains (1) summary
    pfam01044
    Location:63 → 960
    Vinculin; Vinculin family
  2. NM_057472.3 → NP_476820.1  vinculin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476820.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46037
    UniProtKB/TrEMBL
    Q24584, X2JAB9
    Related
    FBpp0070404
    Conserved Domains (1) summary
    pfam01044
    Location:63 → 960
    Vinculin; Vinculin family
  3. NM_001297885.1 → NP_001284814.1  vinculin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284814.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46037
    UniProtKB/TrEMBL
    Q24584, X2JAB9
    Conserved Domains (1) summary
    pfam01044
    Location:63 → 960
    Vinculin; Vinculin family
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