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Hip1 Huntingtin interacting protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39450, updated on 4-Jan-2025

Summary

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Official Symbol
Hip1provided by FlyBase
Official Full Name
Huntingtin interacting protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0036309
Locus tag
Dmel_CG10971
See related
AllianceGenome:FB:FBgn0036309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10971; Dmel\CG10971; hip1; Hip1R
Summary
Predicted to enable several functions, including anion binding activity; clathrin adaptor activity; and clathrin light chain binding activity. Predicted to be involved in actin filament organization; clathrin coat assembly; and endocytosis. Predicted to be active in clathrin-coated vesicle and cortical actin cytoskeleton. Is expressed in adult head. Orthologous to human HIP1 (huntingtin interacting protein 1) and HIP1R (huntingtin interacting protein 1 related). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Hip1 in Genome Data Viewer
Location:
69E2-69E2; 3-39 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12768432..12773573, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12761532..12766673, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Kinesin light chain Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 13D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Huntingtin interacting protein 1 can regulate neurogenesis in Drosophila. Moores JN, et al. Eur J Neurosci, 2008 Aug. PMID 18702731
  2. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Turcot V, et al. Nat Genet, 2018 Jan. PMID 29273807, Free PMC Article
  3. Functionally Validating Evolutionary Conserved Risk Genes for Parkinson's Disease in Drosophila melanogaster. Baisgaard AE, et al. Insects, 2023 Feb 9. PMID 36835737, Free PMC Article
  4. Excess Rab4 rescues synaptic and behavioral dysfunction caused by defective HTT-Rab4 axonal transport in Huntington's disease. White JA 2nd, et al. Acta Neuropathol Commun, 2020 Jul 1. PMID 32611447, Free PMC Article
  5. HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury. Krzystek TJ, et al. Autophagy, 2023 Apr. PMID 36048753, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
enables clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
huntingtin interacting protein 1
Names
CG10971-PA
CG10971-PB
Hip1-PA
Hip1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12768432..12773573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140340.2 → NP_648597.2  huntingtin interacting protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648597.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5A7B5, Q8MQJ8, Q9VU10
    Related
    FBpp0075680
    Conserved Domains (3) summary
    pfam01608
    Location:973 → 1120
    I_LWEQ; I/LWEQ domain
    pfam07651
    Location:9 → 281
    ANTH; ANTH domain
    pfam07851
    Location:402 → 504
    TMPIT; TMPIT-like protein

  2. NM_168513.2 → NP_729827.1  huntingtin interacting protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729827.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5A7B5, Q86BS5
    Related
    FBpp0075681
    Conserved Domains (3) summary
    pfam01608
    Location:936 → 1083
    I_LWEQ; I/LWEQ domain
    pfam07851
    Location:365 → 467
    TMPIT; TMPIT-like protein
    cl02544
    Location:3 → 244
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86BS5 Q86BS5
Q8MQJ8 Q8MQJ8
Q8MQK1 Q8MQK1

Gene LinkOut

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