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    tsr twinstar [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37841, updated on 9-Dec-2024

    Summary

    Official Symbol
    tsrprovided by FlyBase
    Official Full Name
    twinstarprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011726
    Locus tag
    Dmel_CG4254
    See related
    AllianceGenome:FB:FBgn0011726
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    12/8; Adf; ADF; ADF/cofilin; Cadf; cfl; Cfl; CG4254; cofilin; Cofilin; cofilin/actin depolymerizing factor homolog; cofilin/ADF; D-cof; D61; DmCFL; Dmel\CG4254; l(2)03101; l(2)k03101; l(2)k05633; l(2)k13409; ntf; T8; Tsr; Twinstar
    Summary
    Enables actin binding activity. Involved in several processes, including cytoskeleton organization; cytoskeleton-dependent cytokinesis; and nervous system development. Located in cytosol and nucleoplasm. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; follicle cell; and nurse cell. Used to study alcohol use disorder; autism spectrum disorder; and nemaline myopathy 7. Orthologous to human CFL1 (cofilin 1) and DSTN (destrin, actin depolymerizing factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See tsr in Genome Data Viewer
    Location:
    60B5-60B5; 2-106 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24044453..24046805, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19931976..19934328, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene MAN1 Neighboring gene CCR4-NOT transcription complex subunit 11 Neighboring gene Integrator 1 Neighboring gene gamma Soluble NSF attachment protein 1 Neighboring gene seizure Neighboring gene pickpocket 29 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding  
    enables actin binding PubMed 
    enables actin binding PubMed 
    enables actin filament binding  
    Process Evidence Code Pubs
    involved_in actin filament depolymerization  
    involved_in actin filament depolymerization PubMed 
    involved_in actin filament fragmentation  
    involved_in actin filament organization PubMed 
    involved_in actin filament polymerization PubMed 
    involved_in actin filament severing  
    involved_in actomyosin contractile ring assembly PubMed 
    involved_in axonogenesis PubMed 
    involved_in border follicle cell migration PubMed 
    involved_in centrosome separation PubMed 
    involved_in compound eye development PubMed 
    involved_in compound eye morphogenesis PubMed 
    involved_in epithelial structure maintenance PubMed 
    involved_in establishment of imaginal disc-derived wing hair orientation PubMed 
    involved_in establishment of ommatidial planar polarity PubMed 
    involved_in establishment of planar polarity PubMed 
    involved_in female gonad development PubMed 
    involved_in imaginal disc-derived leg segmentation PubMed 
    involved_in lamellipodium assembly PubMed 
    involved_in meiotic cytokinesis PubMed 
    involved_in mitotic cytokinesis PubMed 
    involved_in mushroom body development PubMed 
    involved_in positive regulation of protein secretion PubMed 
    involved_in regulation of lamellipodium assembly PubMed 
    involved_in rhabdomere development PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton  
    located_in actin cytoskeleton  
    is_active_in cytoplasm  
    located_in cytosol PubMed 
    located_in nucleoplasm PubMed 

    General protein information

    Preferred Names
    twinstar
    Names
    ADFcofilin
    CG4254-PA
    Cofilin/actin depolymerizing factor-like
    DCofilin
    actin-depolymerizing factor
    cofilin
    no terminal filament
    tsr-PA
    twin star

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24044453..24046805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057686.4 → NP_477034.1  twinstar [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477034.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6SV25, P45594, Q9W1C4
      UniProtKB/TrEMBL
      A0A1B2AKQ4
      Related
      FBpp0072097
      Conserved Domains (1) summary
      cd11286
      Location:3 → 142
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors
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