Rtnl1 Reticulon-like1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rtnl1provided by FlyBase
Official Full Name: Reticulon-like1provided by FlyBase
Primary source: FLYBASE:FBgn0053113
Locus tag: Dmel_CG33113
See related: AllianceGenome:FB:FBgn0053113
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 142893_at; CG18623; CG33113; CG8895; Dmel\CG33113; G9; Retl1; Rtn1; Rtnl-1; rtnl1; RTNL1
Summary: Enables endoplasmic reticulum-autophagosome adaptor activity and phospholipid binding activity. Involved in endoplasmic reticulum tubular network membrane organization; membrane bending; and reticulophagy. Located in axonal growth cone; fusome; and smooth endoplasmic reticulum. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including cuboidal/columnar epithelium; embryonic/larval midgut primordium; germline cell; germline cyst; and gut section. Used to study hereditary spastic paraplegia and hereditary spastic paraplegia 12. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 12. Orthologous to several human genes including RTN4 (reticulon 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 25B9-25C1; 2-14 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (4992808..5009720, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (4992808..5009720, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development.
Title: PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development.
Drosophila SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca2+ dynamics.
Title: Drosophila SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca2+ dynamics.
Results found that at prometaphase, Rtnl1 is enriched to spindle poles just prior to the endoplasmic reticulum (ER) retention motif KDEL, suggesting a possible recruitment role for Rtnl1 in the bulk localization of ER to spindle poles. Also, the microtubules are necessary for proper Rtnl1 localization. Lastly, astral microtubules, are necessary for proper Rtnl1 localization to spindle poles.
Title: Microtubules are necessary for proper Reticulon localization during mitosis.
this paper shows that Rtnl1 increases arborization at the larval neuromuscular junction
Title: The effects of ER morphology on synaptic structure and function in Drosophila melanogaster.
The loss of Rtnl1 led to the expansion of the rough or sheet ER in larval epidermis and elevated levels of ER stress
Title: Reticulon-like-1, the Drosophila orthologue of the hereditary spastic paraplegia gene reticulon 2, is required for organization of endoplasmic reticulum and of distal motor axons.
Rtnl1-containing membranes colocalize with ribonucleoprotein complexes. As ER is actively transported into the oocyte, this colocalization suggests a role for Rtnl1- subdomain in anchoring the ribonucleoprotein complexes within and/or transporting them.
Title: Rtnl1 is enriched in a specialized germline ER that associates with ribonucleoprotein granule components.
Rtnl1 function appears to be non-essential or redundant since loss of function Rtnl1 mutants are viable. However, a significant reduction in life expectancy was seen in Rtnl1 mutant flies. This may point towards a possible protective
Title: The Drosophila reticulon, Rtnl-1, has multiple differentially expressed isoforms that are associated with a sub-compartment of the endoplasmic reticulum.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables endoplasmic reticulum-autophagosome adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum tubular network membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum tubular network organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane bending	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane bending	TAS Traceable Author Statement more info	PubMed
involved_in reticulophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in endomembrane system	HDA more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum tubular network membrane	IC Inferred by Curator more info	PubMed
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
located_in smooth endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Reticulon-like1

Names: CG33113-PA; CG33113-PB; CG33113-PC; CG33113-PD; CG33113-PE; CG33113-PF; CG33113-PG; CG33113-PH; CG33113-PI; CG33113-PJ; CG33113-PL; Reticulon-like 1; Rtnl1-PA; Rtnl1-PB; Rtnl1-PC; Rtnl1-PD; Rtnl1-PE; Rtnl1-PF; Rtnl1-PG; Rtnl1-PH; Rtnl1-PI; Rtnl1-PJ; Rtnl1-PL; reticulon; reticulon-like1