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Ank Ankyrin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43770, updated on 17-Dec-2024

Summary

Official Symbol
Ankprovided by FlyBase
Official Full Name
Ankyrinprovided by FlyBase
Primary source
FLYBASE:FBgn0011747
Locus tag
Dmel_CG1651
See related
AllianceGenome:FB:FBgn0011747
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ank; ANK; CG1651; CG32008; dank1; Dank1; DAnk1; Dmel\CG1651
Summary
Predicted to enable cytoskeletal anchor activity; spectrin binding activity; and transmembrane transporter binding activity. Predicted to be involved in protein localization to plasma membrane. Located in plasma membrane and spectrosome. Is expressed in several structures, including adult head; adult heart; germline stem cell; ovary; and salivary gland body primordium. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); ankyrin-B-related cardiac arrhythmia; autosomal recessive intellectual developmental disorder 37; bipolar disorder; and heart conduction disease (multiple). Orthologous to several human genes including ANK1 (ankyrin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Ank in Genome Data Viewer
Location:
102A3-102A3; 4-0 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (115074..129849, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (135700..150475, complement)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein S3A Neighboring gene pangolin Neighboring gene long non-coding RNA:CR43956 Neighboring gene anne boleyn Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

mobile_element

  • Loc: c119039-118965 mobile_element_type = transposon:INE-1{}4171
  • Loc: c126666-125492 mobile_element_type = transposon:Tc1{}1485
  • Loc: c128439-128086 mobile_element_type = transposon:S2{}1486
  • Loc: c128824-127987 mobile_element_type = transposon:INE-1{}4640
  • Loc: c129057-128965 mobile_element_type = transposon:INE-1{}4643

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cytoskeletal anchor activity  
enables spectrin binding  
enables transmembrane transporter binding  
Process Evidence Code Pubs
involved_in protein localization to plasma membrane  
involved_in signal transduction  
Component Evidence Code Pubs
is_active_in neuron projection  
located_in plasma membrane PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in spectrosome PubMed 

General protein information

Preferred Names
ankyrin
Names
Ank-PB
Ank-PC
Ank-PD
Ank-PE
Ank1
CG1651-PB
CG1651-PC
CG1651-PD
CG1651-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    115074..129849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169348.2 → NP_001162819.1  ankyrin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162819.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KIE7, Q24241
    Conserved Domains (7) summary
    smart00218
    Location:930 → 1034
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:491 → 616
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08317
    Location:1439 → 1521
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:633 → 723
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:300 → 353
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:582 → 636
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:496 → 527
    ANK; ANK repeat [structural motif]
  2. NM_175927.3 → NP_787123.1  ankyrin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_787123.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KIE7, Q24241
    Related
    FBpp0088238
    Conserved Domains (7) summary
    smart00218
    Location:930 → 1034
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:491 → 616
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08317
    Location:1439 → 1521
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:633 → 723
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:300 → 353
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:582 → 636
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:496 → 527
    ANK; ANK repeat [structural motif]
  3. NM_175928.3 → NP_787124.1  ankyrin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_787124.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KIE7, Q24241
    Related
    FBpp0088239
    Conserved Domains (7) summary
    smart00218
    Location:930 → 1034
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:491 → 616
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08317
    Location:1439 → 1521
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:633 → 723
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:300 → 353
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:582 → 636
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:496 → 527
    ANK; ANK repeat [structural motif]
  4. NM_175926.3 → NP_787122.1  ankyrin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_787122.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KIE7, Q24241
    Related
    FBpp0088240
    Conserved Domains (7) summary
    smart00218
    Location:930 → 1034
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:491 → 616
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08317
    Location:1439 → 1521
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:633 → 723
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:300 → 353
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:582 → 636
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:496 → 527
    ANK; ANK repeat [structural motif]
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