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hmp-1 Alpha-catenin-like protein hmp-1;Vinculin [ Caenorhabditis elegans ]

Gene ID: 179624, updated on 9-Dec-2024

Summary

Official Symbol
hmp-1
Official Full Name
Alpha-catenin-like protein hmp-1;Vinculin
Primary source
WormBase:WBGene00001978
Locus tag
CELE_R13H4.4
See related
AllianceGenome:WB:WBGene00001978
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables actin filament binding activity and beta-catenin binding activity. Involved in several processes, including cortical actin cytoskeleton organization; embryonic morphogenesis; and regulation of actin cytoskeleton organization. Located in adherens junction and apical junction complex. Part of catenin complex. Is expressed in several structures, including germ cell; intestinal cell; neuroblasts; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular dysplasia 13; complex cortical dysplasia with other brain malformations; and patterned macular dystrophy 2. Orthologous to several human genes including CTNNA2 (catenin alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See hmp-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (11845871..11852166)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Intrinsically Disordered Protein, class B Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box domain-containing protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin filament binding  
enables actin filament binding PubMed 
enables actin filament binding  
enables beta-catenin binding  
enables beta-catenin binding PubMed 
enables cadherin binding  
enables protein binding PubMed 
Component Evidence Code Pubs
is_active_in adherens junction  
located_in adherens junction PubMed 
located_in adherens junction  
located_in anchoring junction  
located_in apical junction complex PubMed 
part_of catenin complex  
part_of catenin complex PubMed 
located_in cytoplasm  

General protein information

Preferred Names
Alpha-catenin-like protein hmp-1;Vinculin
NP_001122991.1
  • Confirmed by transcript evidence
NP_001256379.1
  • Confirmed by transcript evidence
NP_001263866.1
  • Confirmed by transcript evidence
NP_001360176.1
  • Confirmed by transcript evidence
NP_001370891.1
  • Confirmed by transcript evidence
NP_505985.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11845871..11852166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373121.3NP_001360176.1  Vinculin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    I7K4K5
    Conserved Domains (1) summary
    pfam01044
    Location:15848
    Vinculin; Vinculin family
  2. NM_001129519.3NP_001122991.1  Vinculin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122991.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5JYX3
    Conserved Domains (1) summary
    pfam01044
    Location:77869
    Vinculin; Vinculin family
  3. NM_073584.7NP_505985.1  Alpha-catenin-like protein hmp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505985.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90947
    Conserved Domains (1) summary
    pfam01044
    Location:77869
    Vinculin; Vinculin family
  4. NM_001383414.1NP_001370891.1  Vinculin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    I7J4D2
    Conserved Domains (1) summary
    pfam01044
    Location:77855
    Vinculin; Vinculin family
  5. NM_001276937.3NP_001263866.1  Vinculin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263866.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    I7LFF2
    Conserved Domains (1) summary
    pfam01044
    Location:77848
    Vinculin; Vinculin family
  6. NM_001269450.3NP_001256379.1  Alpha-catenin-like protein hmp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256379.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F5GUG3
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