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nova-1 K Homology domain-containing protein;KH domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180183, updated on 2-Nov-2024

Summary

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Official Symbol
nova-1
Official Full Name
K Homology domain-containing protein;KH domain-containing protein
Primary source
WormBase:WBGene00013347
Locus tag
CELE_Y59A8B.10
See related
AllianceGenome:WB:WBGene00013347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in cytoplasm and nucleus. Orthologous to several human genes including NOVA1 (NOVA alternative splicing regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nova-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (18070004..18081957, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene EB1 C-terminal domain-containing protein Neighboring gene Gamma-soluble NSF attachment protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene MATH domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Berends CW, et al. Mol Biol Cell, 2013 Jul. PMID 23699393, Free PMC Article
  2. Robust regulatory architecture of pan-neuronal gene expression. Leyva-Díaz E, et al. Curr Biol, 2022 Apr 25. PMID 35259341, Free PMC Article
  3. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
  4. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article
  5. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
K Homology domain-containing protein;KH domain-containing protein
NP_001256769.1
  • Confirmed by transcript evidence
NP_001256770.1
  • Confirmed by transcript evidence
NP_001256771.1
  • Confirmed by transcript evidence
NP_001360614.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    18070004..18081957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269840.2 → NP_001256769.1  K Homology domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256769.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GRY9
    Conserved Domains (1) summary
    cd02396
    Location:43 → 109
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

  2. NM_001373184.1 → NP_001360614.1  K Homology domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0ILI5
    Conserved Domains (1) summary
    cd02396
    Location:47 → 113
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

  3. NM_001269841.3 → NP_001256770.1  K Homology domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256770.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E0R7K7
    Conserved Domains (1) summary
    cd02396
    Location:34 → 103
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

  4. NM_001269842.3 → NP_001256771.1  KH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256771.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E0R7K8
Nucleotide Protein
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