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flh-1 FLYWCH transcription factor 1 [ Caenorhabditis elegans ]

Gene ID: 177749, updated on 4-Jan-2025

Summary

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Official Symbol
flh-1
Official Full Name
FLYWCH transcription factor 1
Primary source
WormBase:WBGene00012435
Locus tag
CELE_Y11D7A.12
See related
AllianceGenome:WB:WBGene00012435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription and nematode larval development. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See flh-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (9261807..9264270, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Complex I-B8;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4;Transposase Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Neighboring gene FLYWCH transcription factor 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Predicting mutation outcome from early stochastic variation in genetic interaction partners. Burga A, et al. Nature, 2011 Dec 7. PMID 22158248
  2. The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans. Ow MC, et al. Genes Dev, 2008 Sep 15. PMID 18794349, Free PMC Article
  3. DNA binding and in vivo function of C.elegans PEB-1 require a conserved FLYWCH motif. Beaster-Jones L, et al. J Mol Biol, 2004 Jun 11. PMID 15165844
  4. Transcriptional control of microRNA expression in C. elegans: promoting better understanding. Turner MJ, et al. RNA Biol, 2009 Jan-Mar. PMID 19106630, Free PMC Article
  5. miRNAs give worms the time of their lives: small RNAs and temporal control in Caenorhabditis elegans. Resnick TD, et al. Dev Dyn, 2010 May. PMID 20232378, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
FLYWCH transcription factor 1
NP_001122806.1
  • Partially confirmed by transcript evidence
NP_001255383.1
  • Confirmed by transcript evidence
NP_501618.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9261807..9264270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129334.4 → NP_001122806.1  FLYWCH transcription factor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122806.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7DTF1
    Conserved Domains (1) summary
    pfam04500
    Location:133 → 192
    FLYWCH; FLYWCH zinc finger domain

  2. NM_069217.9 → NP_501618.2  FLYWCH transcription factor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501618.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7DTF1, D3NQA3, Q9XWR1
    Conserved Domains (1) summary
    pfam04500
    Location:133 → 192
    FLYWCH; FLYWCH zinc finger domain

  3. NM_001268454.3 → NP_001255383.1  FLYWCH transcription factor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255383.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3NQA3
    Conserved Domains (1) summary
    pfam04500
    Location:127 → 186
    FLYWCH; FLYWCH zinc finger domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XWR1.2

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