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    spidey spidey [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31703, updated on 9-Dec-2024

    Summary

    Official Symbol
    spideyprovided by FlyBase
    Official Full Name
    spideyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029975
    Locus tag
    Dmel_CG1444
    See related
    AllianceGenome:FB:FBgn0029975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1444; Dmel\CG1444; Kar; KAR; KAR[CG1444]
    Summary
    Predicted to enable very-long-chain 3-oxoacyl-CoA reductase activity. Involved in cellular response to nutrient levels; negative regulation of cell growth; and positive regulation of lipid storage. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to several human genes including HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See spidey in Genome Data Viewer
    Location:
    7C2-7C2; 1-21 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7908931..7911885)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7802964..7805918)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene by S6 Neighboring gene defective proboscis extension response 14 Neighboring gene snazarus Neighboring gene hold'em

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity  
    enables very-long-chain 3-oxoacyl-CoA reductase activity  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum  

    General protein information

    Preferred Names
    spidey
    Names
    CG1444-PA
    spidey-PA
    NP_572420.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7908931..7911885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132192.3 → NP_572420.1  spidey [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572420.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3N1
      Related
      FBpp0071047
      Conserved Domains (2) summary
      PLN02780
      Location:8 → 321
      PLN02780; ketoreductase/ oxidoreductase
      cd05356
      Location:52 → 288
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
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