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CG2065 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35707, updated on 9-Dec-2024

Summary

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Official Symbol
CG2065provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033204
Locus tag
Dmel_CG2065
See related
AllianceGenome:FB:FBgn0033204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG2065
Summary
Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in retinal metabolic process. Located in endoplasmic reticulum membrane. Is expressed in adult fat body; adult head; gnathal primordium; larval foregut atrium; and yolk nucleus. Orthologous to human RDH13 (retinol dehydrogenase 13). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG2065 in Genome Data Viewer
Location:
43E8-43E9; 2-57 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7663786..7665269)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3551291..3552774)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor-like 43a Neighboring gene uncharacterized protein Neighboring gene Retinol dehydrogenase 1 Neighboring gene Dynactin 4, p62 subunit Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster. Belyaeva OV, et al. Biochim Biophys Acta, 2009 Oct. PMID 19520149, Free PMC Article
  2. Mining gene expression data for pollutants (dioxin, toluene, formaldehyde) and low dose of gamma-irradiation. Moskalev A, et al. PLoS One, 2014. PMID 24475070, Free PMC Article
  3. Two new and distinct roles for Drosophila Argonaute-2 in the nucleus: alternative pre-mRNA splicing and transcriptional repression. Taliaferro JM, et al. Genes Dev, 2013 Feb 15. PMID 23392611, Free PMC Article
  4. Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease. Rival T, et al. Eur J Neurosci, 2009 Apr. PMID 19519625, Free PMC Article
  5. Dietary Curcumin Intake and Its Effects on the Transcriptome and Metabolome of Drosophila melanogaster. Belcher S, et al. Int J Mol Sci, 2024 Jun 14. PMID 38928266, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables all-trans-retinol dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in retinal metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG2065-PA
CG2065-PB
NP_001260787.1
NP_610309.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7663786..7665269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273858.1 → NP_001260787.1  uncharacterized protein Dmel_CG2065, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260787.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JYX2
    Conserved Domains (2) summary
    PRK06197
    Location:11 → 294
    PRK06197; short chain dehydrogenase; Provisional
    cl21454
    Location:14 → 288
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_136465.4 → NP_610309.1  uncharacterized protein Dmel_CG2065, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610309.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JYX2
    Related
    FBpp0087996
    Conserved Domains (2) summary
    PRK06197
    Location:11 → 294
    PRK06197; short chain dehydrogenase; Provisional
    cl21454
    Location:14 → 288
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JYX2 Q7JYX2

Gene LinkOut

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