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Patronin patronin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36978, updated on 17-Dec-2024

Summary

Official Symbol
Patroninprovided by FlyBase
Official Full Name
patroninprovided by FlyBase
Primary source
FLYBASE:FBgn0263197
Locus tag
Dmel_CG33130
See related
AllianceGenome:FB:FBgn0263197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD17191; CG18459; CG18460; CG18462; CG30102; CG33130; CG6516; Dmel\CG33130; l(2)k07433; Patr; patronin; ptrn; ssp4; Ssp4
Summary
Enables microtubule minus-end binding activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; microtubule cytoskeleton organization; and negative regulation of hippo signaling. Located in several cellular components, including anterior cell cortex; microtubule cytoskeleton; and subapical part of cell. Is expressed in adult head; embryonic/larval dorsal vessel; organism; and spermatozoon. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to several human genes including CAMSAP1 (calmodulin regulated spectrin associated protein 1) and CAMSAP2 (calmodulin regulated spectrin associated protein family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Patronin in Genome Data Viewer
Location:
54C1-54C3; 2-83 cM
Exon count:
24
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17519024..17535866, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13406529..13423371, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cathepsin K2 Neighboring gene uncharacterized protein Neighboring gene Anaphase Promoting Complex subunit 10 Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit b Neighboring gene Coiled-coil and C2 domain containing 2A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calmodulin binding  
enables microtubule binding  
enables microtubule binding PubMed 
enables microtubule minus-end binding  
enables microtubule minus-end binding PubMed 
enables microtubule minus-end binding PubMed 
enables spectrin binding  
Component Evidence Code Pubs
located_in anterior cell cortex PubMed 
located_in centrosome PubMed 
located_in lateral cell cortex PubMed 
located_in microtubule PubMed 
colocalizes_with microtubule minus-end  
located_in midbody PubMed 
located_in mitotic spindle PubMed 
located_in spindle PubMed 
located_in subapical part of cell PubMed 

General protein information

Preferred Names
patronin
Names
CG33130-PA
CG33130-PB
CG33130-PC
CG33130-PD
CG33130-PE
CG33130-PF
CG33130-PI
CG33130-PJ
CG33130-PK
CG33130-PL
CG33130-PM
CG33130-PN
CG33130-PO
Patronin-PA
Patronin-PB
Patronin-PC
Patronin-PD
Patronin-PE
Patronin-PF
Patronin-PI
Patronin-PJ
Patronin-PK
Patronin-PL
Patronin-PM
Patronin-PN
Patronin-PO
lethal (2) k07433
short spindle 4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17519024..17535866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274127.1 → NP_001261056.1  patronin, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261056.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEY6, A0A0U3DWR7
    Conserved Domains (4) summary
    TIGR02794
    Location:1050 → 1170
    tolA_full; TolA protein
    pfam08683
    Location:1299 → 1417
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:188 → 267
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:474 → 540
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  2. NM_001144218.3 → NP_001137690.1  patronin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137690.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZJ1, H6WS59
    Conserved Domains (4) summary
    TIGR02794
    Location:1250 → 1370
    tolA_full; TolA protein
    pfam08683
    Location:1523 → 1641
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:189 → 272
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:591 → 658
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  3. NM_001274125.1 → NP_001261054.1  patronin, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261054.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG58, H6WS59
    Conserved Domains (4) summary
    TIGR02794
    Location:1186 → 1306
    tolA_full; TolA protein
    pfam08683
    Location:1398 → 1516
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:189 → 272
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:577 → 644
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  4. NM_206153.3 → NP_995875.1  patronin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995875.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZAU8, A1ZAU9, A1ZAV0, Q86NU5, Q8MSU7
    UniProtKB/TrEMBL
    H6WS59
    Conserved Domains (4) summary
    TIGR02794
    Location:1217 → 1337
    tolA_full; TolA protein
    pfam08683
    Location:1490 → 1608
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:189 → 272
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:591 → 658
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  5. NM_001144219.3 → NP_001137691.1  patronin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137691.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZJ2, H6WS59
    Conserved Domains (4) summary
    TIGR02794
    Location:1271 → 1391
    tolA_full; TolA protein
    pfam08683
    Location:1459 → 1577
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:189 → 272
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:612 → 679
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  6. NM_001274122.1 → NP_001261051.1  patronin, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261051.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEY4, H6WS59
    Conserved Domains (4) summary
    TIGR02794
    Location:1271 → 1391
    tolA_full; TolA protein
    pfam08683
    Location:1549 → 1667
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:189 → 272
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:612 → 679
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  7. NM_001169706.2 → NP_001163177.2  patronin, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163177.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JH91, H6WS59
    Conserved Domains (4) summary
    TIGR02794
    Location:1271 → 1391
    tolA_full; TolA protein
    pfam08683
    Location:1543 → 1661
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:189 → 272
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:612 → 679
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  8. NM_001169704.2 → NP_001163175.1  patronin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163175.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JH90, H6WS59
    Conserved Domains (4) summary
    TIGR02794
    Location:1271 → 1391
    tolA_full; TolA protein
    pfam08683
    Location:1531 → 1649
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:189 → 272
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:612 → 679
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  9. NM_001274126.1 → NP_001261055.1  patronin, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261055.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFU3, A0A0U3DWR7
    Conserved Domains (4) summary
    TIGR02794
    Location:1140 → 1260
    tolA_full; TolA protein
    pfam08683
    Location:1364 → 1482
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:189 → 272
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:530 → 597
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  10. NM_001274124.1 → NP_001261053.1  patronin, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261053.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFA4, H6WS59
    Conserved Domains (4) summary
    TIGR02794
    Location:1287 → 1407
    tolA_full; TolA protein
    pfam08683
    Location:1540 → 1658
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:189 → 272
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:628 → 695
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  11. NM_001274123.1 → NP_001261052.1  patronin, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261052.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KET5, H6WS59
    Conserved Domains (4) summary
    TIGR02794
    Location:1321 → 1441
    tolA_full; TolA protein
    pfam08683
    Location:1534 → 1652
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:189 → 272
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:663 → 730
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  12. NM_206154.3 → NP_995876.1  patronin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995876.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H6WS59
    Conserved Domains (4) summary
    TIGR02794
    Location:1189 → 1309
    tolA_full; TolA protein
    pfam08683
    Location:1400 → 1518
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:189 → 272
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:612 → 679
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  13. NM_176218.3 → NP_788398.1  patronin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788398.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0U3DWR7
    Related
    FBpp0086104
    Conserved Domains (4) summary
    TIGR02794
    Location:1189 → 1309
    tolA_full; TolA protein
    pfam08683
    Location:1377 → 1495
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:189 → 272
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:612 → 679
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
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